Imperial College London
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MissLucyWilliams

Faculty of Medicine, School of Public Health

Research Postgraduate
 
 
 
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Contact

 

lucy.williams19 Website

 
 
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Location

 

Sir Michael Uren HubWhite City Campus

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Summary

 

Publications

Citation

BibTex format

@article{Imai:2021:10.12688/wellcomeopenres.16992.1,
author = {Imai, N and Hogan, AB and Williams, L and Cori, A and Mangal, TD and Winskill, P and Whittles, LK and Watson, OJ and Knock, ES and Baguelin, M and Perez-Guzman, PN and Gaythorpe, KAM and Sonabend, R and Ghani, AC and Ferguson, NM},
doi = {10.12688/wellcomeopenres.16992.1},
journal = {Wellcome Open Research},
pages = {185--185},
title = {Interpreting estimates of coronavirus disease 2019 (COVID-19) vaccine efficacy and effectiveness to inform simulation studies of vaccine impact: a systematic review},
url = {http://dx.doi.org/10.12688/wellcomeopenres.16992.1},
volume = {6},
year = {2021}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - <ns3:p><ns3:bold>Background:</ns3:bold> The multiple efficacious vaccines authorised for emergency use worldwide represent the first preventative intervention against coronavirus disease 2019 (COVID-19) that does not rely on social distancing measures. The speed at which data are emerging and the heterogeneities in study design, target populations, and implementation make it challenging to interpret and assess the likely impact of vaccine campaigns on local epidemics. We reviewed available vaccine efficacy and effectiveness studies to generate working estimates that can be used to parameterise simulation studies of vaccine impact.</ns3:p><ns3:p> <ns3:bold>Methods:</ns3:bold> We searched MEDLINE, the World Health Organization’s Institutional Repository for Information Sharing, medRxiv, and vaccine manufacturer websites for studies that evaluated the emerging data on COVID-19 vaccine efficacy and effectiveness. Studies providing an estimate of the efficacy or effectiveness of a COVID-19 vaccine using disaggregated data against SARS-CoV-2 infection, symptomatic disease, severe disease, death, or transmission were included. We extracted information on study population, variants of concern (VOC), vaccine platform, dose schedule, study endpoints, and measures of impact. We applied an evidence synthesis approach to capture a range of plausible and consistent parameters for vaccine efficacy and effectiveness that can be used to inform and explore a variety of vaccination strategies as the COVID-19 pandemic evolves.</ns3:p><ns3:p> <ns3:bold>Results:</ns3:bold> Of the 602 articles and reports identified, 53 were included in the analysis. The availability of vaccine efficacy and effectiveness estimates varied by vaccine and were limited for VOCs. Estimates for non-primary endpoints such as effectiveness against infection and onward transmission were sparse. Synthesised estimates were relatively consistent
AU  - Imai,N
AU  - Hogan,AB
AU  - Williams,L
AU  - Cori,A
AU  - Mangal,TD
AU  - Winskill,P
AU  - Whittles,LK
AU  - Watson,OJ
AU  - Knock,ES
AU  - Baguelin,M
AU  - Perez-Guzman,PN
AU  - Gaythorpe,KAM
AU  - Sonabend,R
AU  - Ghani,AC
AU  - Ferguson,NM
DO  - 10.12688/wellcomeopenres.16992.1
EP  - 185
PY  - 2021///
SP  - 185
TI  - Interpreting estimates of coronavirus disease 2019 (COVID-19) vaccine efficacy and effectiveness to inform simulation studies of vaccine impact: a systematic review
T2  - Wellcome Open Research
UR  - http://dx.doi.org/10.12688/wellcomeopenres.16992.1
VL  - 6
ER  -
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