Imperial College London

Dr Luke A. Yates

Faculty of MedicineDepartment of Infectious Disease

Research Associate







245Sir Alexander Fleming BuildingSouth Kensington Campus





The use of biochemistry allows us to explain physiological events at a molecular level and this insight offers the opportunity for the development of therapeutics for human disease. It is this perspective that has driven me along my career path to date. In this vein, I have pursued a research career focused on investigating protein function using structural biology and associated molecular biology and biophysical techniques to provide a mechanistic understanding in life and in disease and I have been fortunate to contribute to this understanding during my research.

Outside of research, my interests extend to medical ethics, for which I am a member of the Imperial Clinical Ethics Committee.

I am also a trustee for the organ donation charity, Live Life Give Life and am the creator of Art Transplant.



Yates LA, Zhang X, 2023, Phosphoregulation of the checkpoint kinase Mec1ATR, Dna Repair, Vol:129, ISSN:1568-7864

Liang P, Lister K, Yates L, et al., 2023, Phosphoregulation of DNA repair via the Rad51 auxiliary factor Swi5-Sfr1, Journal of Biological Chemistry, Vol:299, ISSN:0021-9258, Pages:1-15

Zhang X, Yates L, Morgan M, 2023, A DNA damage-induced phosphorylation circuit enhances Mec1ATR Ddc2ATRIP recruitment to Replication Protein A, Proceedings of the National Academy of Sciences of Usa, Vol:120, ISSN:0027-8424, Pages:1-10

Yates LA, 2021, Regulation of DNA break repair by RNA, Progress in Biophysics & Molecular Biology, Vol:163, ISSN:0079-6107, Pages:23-33

Tannous EA, Yates LA, Zhang X, et al., 2021, Mechanism of auto-inhibition and activation of Mec1ATR checkpoint kinase, Nature Structural and Molecular Biology, Vol:28, ISSN:1545-9985, Pages:50-61

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