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@article{Lavezzo:2020:10.1038/s41586-020-2488-1,
author = {Lavezzo, E and Franchin, E and Ciavarella, C and Cuomo-Dannenburg, G and Barzon, L and Del, Vecchio C and Rossi, L and Manganelli, R and Loregian, A and Navarin, N and Abate, D and Sciro, M and Merigliano, S and De, Canale E and Vanuzzo, MC and Besutti, V and Saluzzo, F and Onelia, F and Pacenti, M and Parisi, S and Carretta, G and Donato, D and Flor, L and Cocchio, S and Masi, G and Sperduti, A and Cattarino, L and Salvador, R and Nicoletti, M and Caldart, F and Castelli, G and Nieddu, E and Labella, B and Fava, L and Drigo, M and Gaythorpe, KAM and Imperial, College COVID-19 Response Team and Brazzale, AR and Toppo, S and Trevisan, M and Baldo, V and Donnelly, CA and Ferguson, NM and Dorigatti, I and Crisanti, A},
doi = {10.1038/s41586-020-2488-1},
journal = {Nature},
pages = {425--429},
title = {Suppression of a SARS-CoV-2 outbreak in the Italian municipality of Vo'},
url = {http://dx.doi.org/10.1038/s41586-020-2488-1},
volume = {584},
year = {2020}
}

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TY  - JOUR
AB  - On the 21st of February 2020 a resident of the municipality of Vo', a small town near Padua, died of pneumonia due to SARS-CoV-2 infection1. This was the first COVID-19 death detected in Italy since the emergence of SARS-CoV-2 in the Chinese city of Wuhan, Hubei province2. In response, the regional authorities imposed the lockdown of the whole municipality for 14 days3. We collected information on the demography, clinical presentation, hospitalization, contact network and presence of SARS-CoV-2 infection in nasopharyngeal swabs for 85.9% and 71.5% of the population of Vo' at two consecutive time points. On the first survey, which was conducted around the time the town lockdown started, we found a prevalence of infection of 2.6% (95% confidence interval (CI) 2.1-3.3%). On the second survey, which was conducted at the end of the lockdown, we found a prevalence of 1.2% (95% Confidence Interval (CI) 0.8-1.8%). Notably, 42.5% (95% CI 31.5-54.6%) of the confirmed SARS-CoV-2 infections detected across the two surveys were asymptomatic (i.e. did not have symptoms at the time of swab testing and did not develop symptoms afterwards). The mean serial interval was 7.2 days (95% CI 5.9-9.6). We found no statistically significant difference in the viral load of symptomatic versus asymptomatic infections (p-values 0.62 and 0.74 for E and RdRp genes, respectively, Exact Wilcoxon-Mann-Whitney test). This study sheds new light on the frequency of asymptomatic SARS-CoV-2 infection, their infectivity (as measured by the viral load) and provides new insights into its transmission dynamics and the efficacy of the implemented control measures.
AU  - Lavezzo,E
AU  - Franchin,E
AU  - Ciavarella,C
AU  - Cuomo-Dannenburg,G
AU  - Barzon,L
AU  - Del,Vecchio C
AU  - Rossi,L
AU  - Manganelli,R
AU  - Loregian,A
AU  - Navarin,N
AU  - Abate,D
AU  - Sciro,M
AU  - Merigliano,S
AU  - De,Canale E
AU  - Vanuzzo,MC
AU  - Besutti,V
AU  - Saluzzo,F
AU  - Onelia,F
AU  - Pacenti,M
AU  - Parisi,S
AU  - Carretta,G
AU  - Donato,D
AU  - Flor,L
AU  - Cocchio,S
AU  - Masi,G
AU  - Sperduti,A
AU  - Cattarino,L
AU  - Salvador,R
AU  - Nicoletti,M
AU  - Caldart,F
AU  - Castelli,G
AU  - Nieddu,E
AU  - Labella,B
AU  - Fava,L
AU  - Drigo,M
AU  - Gaythorpe,KAM
AU  - Imperial,College COVID-19 Response Team
AU  - Brazzale,AR
AU  - Toppo,S
AU  - Trevisan,M
AU  - Baldo,V
AU  - Donnelly,CA
AU  - Ferguson,NM
AU  - Dorigatti,I
AU  - Crisanti,A
DO  - 10.1038/s41586-020-2488-1
EP  - 429
PY  - 2020///
SN  - 0028-0836
SP  - 425
TI  - Suppression of a SARS-CoV-2 outbreak in the Italian municipality of Vo'
T2  - Nature
UR  - http://dx.doi.org/10.1038/s41586-020-2488-1
UR  - https://www.ncbi.nlm.nih.gov/pubmed/32604404
UR  - https://www.nature.com/articles/s41586-020-2488-1
UR  - http://hdl.handle.net/10044/1/80363
VL  - 584
ER  -

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