I am interested in the structural biology and biochemistry of retroviral integration. Succesful retroviral replication relies strictly on the ability of the virus to insert a copy of its genetic information into the genome of the host. Modern structural techniques such as X-ray crystallography, NMR and electron microscopy allow to visualise this biochemical process in atomic detail. Understanding retroviral integration is a step towards effective treatment against viruses such as HIV or HTLV and provides opportunity for a deeper understanding of DNA recombination and host-pathogen interactions.
et al., 2020, Cryo-EM structure of the deltaretroviral intasome in complex with the PP2A regulatory subunit B56γ, Nature Communications, Vol:11, ISSN:2041-1723
Barski MS, Minnell JJ, Maertens G, 2019, Inhibition of HTLV-1 infection by HIV-1 first- and second-generation integrase strand transfer inhibitors, Frontiers in Microbiology, Vol:10, ISSN:1664-302X
Barski M, 2018, BASILIScan: a tool for high-throughput analysis of intrinsic disorder patterns in homologous proteins, Bmc Genomics, Vol:19, ISSN:1471-2164
et al., 2017, Rift Valley fever phlebovirus NSs protein core domain structure suggests molecular basis for nuclear filaments., Elife, Vol:6, ISSN:2050-084X