Imperial College London
Alternate

ProfessorMaria-GloriaBasanez

Faculty of Medicine, School of Public Health

Professor of Neglected Tropical Diseases
 
 
 
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Contact

 

+44 (0)20 7594 3295m.basanez Website

 
 
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Location

 

503School of Public HealthWhite City Campus

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Summary

 

Publications

Publication Type
Year
to

272 results found

Walker M, Winskill P, Basanez M-G, Mwangangi JM, Mbogo C, Beier JC, Midega JTet al., 2013, Temporal and micro-spatial heterogeneity in the distribution of <i>Anopheles</i> vectors of malaria along the Kenyan coast, PARASITES & VECTORS, Vol: 6, ISSN: 1756-3305

Journal article

Turner HC, Osei-Atweneboana MY, Walker M, Tettevi EJ, Churcher TS, Asiedu O, Biritwum N-K, Basanez M-Get al., 2013, The Cost of Annual versus Biannual Community-Directed Treatment of Onchocerciasis with Ivermectin: Ghana as a Case Study, PLOS NEGLECTED TROPICAL DISEASES, Vol: 7, ISSN: 1935-2735

Journal article

Post RJ, Cheke RA, Boakye DA, Wilson MD, Osei-Atweneboana MY, Tetteh-Kumah A, Lamberton PHL, Crainey JL, Yameogo L, Basanez M-Get al., 2013, Stability and change in the distribution of cytospecies of the <i>Simulium</i> <i>damnosum</i> complex (Diptera: Simuliidae) in southern Ghana from 1971 to 2011, PARASITES & VECTORS, Vol: 6, ISSN: 1756-3305

Journal article

Rudge JW, Webster JP, Lu D-B, Wang T-P, Fang G-R, Basanez M-Get al., 2013, Identifying host species driving transmission of schistosomiasis japonica, a multi-host parasite system, in China, Proceedings of the National Academy of Sciences of the United States of America

Journal article

Churcher TS, Bousema T, Walker M, Drakeley C, Schneider P, Ouedraogo AL, Basanez M-Get al., 2013, Predicting mosquito infection from <i>Plasmodium falciparum</i> gametocyte density and estimating the reservoir of infection, ELIFE, Vol: 2, ISSN: 2050-084X

Journal article

Walker M, Hall A, Basáñez M-G, 2013, Ascaris lumbricoides: New Epidemiological Insights and Mathematical Approaches, Ascaris: The Neglected Parasite, Editors: Holland, Publisher: Newnes, Pages: 155-201, ISBN: 9780123972859

Book chapter

Diawara A, Halpenny CM, Churcher TS, Mwandawiro C, Kihara J, Kaplan RM, Streit TG, Idaghdour Y, Scott ME, Basanez M-G, Prichard RKet al., 2013, Association between Response to Albendazole Treatment and β-Tubulin Genotype Frequencies in Soil-transmitted Helminths, PLOS NEGLECTED TROPICAL DISEASES, Vol: 7, ISSN: 1935-2735

Journal article

Koukounari A, Moustaki I, Grassly NC, Blake IM, Basanez M-G, Gambhir M, Mabey DCW, Bailey RL, Burton MJ, Solomon AW, Donnelly CAet al., 2013, Using a Nonparametric Multilevel Latent Markov Model to Evaluate Diagnostics for Trachoma, American Journal of Epidemiology, Vol: 177, Pages: 913-922, ISSN: 0002-9262

In disease control or elimination programs, diagnostics are essential for assessing the impact of interventions, refining treatment strategies, and minimizing the waste of scarce resources. Although high-performance tests are desirable, increased accuracy is frequently accompanied by a requirement for more elaborate infrastructure, which is often not feasible in the developing world. These challenges are pertinent to mapping, impact monitoring, and surveillance in trachoma elimination programs. To help inform rational design of diagnostics for trachoma elimination, we outline a nonparametric multilevel latent Markov modeling approach and apply it to 2 longitudinal cohort studies of trachoma-endemic communities in Tanzania (2000–2002) and The Gambia (2001–2002) to provide simultaneous inferences about the true population prevalence of Chlamydia trachomatis infection and disease and the sensitivity, specificity, and predictive values of 3 diagnostic tests for C. trachomatis infection. Estimates were obtained by using data collected before and after mass azithromycin administration. Such estimates are particularly important for trachoma because of the absence of a true “gold standard” diagnostic test for C. trachomatis. Estimated transition probabilities provide useful insights into key epidemiologic questions about the persistence of disease and the clearance of infection as well as the required frequency of surveillance in the postelimination setting.

Journal article

Coffeng LE, Pion SDS, O'Hanlon S, Cousens S, Abiose AO, Fischer PU, Remme JHF, Dadzie KY, Murdoch ME, de Vlas SJ, Basanez M-G, Stolk WA, Boussinesq Met al., 2013, Onchocerciasis: The Pre-control Association between Prevalence of Palpable Nodules and Skin Microfilariae, PLOS NEGLECTED TROPICAL DISEASES, Vol: 7, ISSN: 1935-2735

Journal article

Turner HC, Churcher TS, Walker M, Osei-Atweneboana MY, Prichard RK, Basanez M-Get al., 2013, Uncertainty Surrounding Projections of the Long-Term Impact of Ivermectin Treatment on Human Onchocerciasis, PLOS NEGLECTED TROPICAL DISEASES, Vol: 7, ISSN: 1935-2735

Journal article

Pollitt LC, Churcher TS, Dawes EJ, Khan SM, Sajid M, Basáñez M-G, Colegrave N, Reece SEet al., 2013, Costs of crowding for the transmission of malaria parasites, Evolutionary Applications, Pages: n/a-n/a, ISSN: 1752-4571

Journal article

Botto C, Villamizar N, Jokić Ž, Noya-Alarcón O, Cortéz J, Escalona M, Grillet ME, Basanez MGet al., 2013, Landscape Epidemiology of Human Onchocerciasis in SouthernVenezuela, Earth Systems and Environmental Sciences, Publisher: Elsevier Inc.

Book chapter

Murray CJL, Vos T, Lozano R, Naghavi M, Flaxman AD, Michaud C, Ezzati M, Shibuya K, Salomon JA, Abdalla S, Aboyans V, Abraham J, Ackerman I, Aggarwal R, Ahn SY, Ali MK, Alvarado M, Anderson HR, Anderson LM, Andrews KG, Atkinson C, Baddour LM, Bahalim AN, Barker-Collo S, Barrero LH, Bartels DH, Basanez M-G, Baxter A, Bell ML, Benjamin EJ, Bennett D, Bernabe E, Bhalla K, Bhandari B, Bikbov B, Bin Abdulhak A, Birbeck G, Black JA, Blencowe H, Blore JD, Blyth F, Bolliger I, Bonaventure A, Boufous SA, Bourne R, Boussinesq M, Braithwaite T, Brayne C, Bridgett L, Brooker S, Brooks P, Brugha TS, Bryan-Hancock C, Bucello C, Buchbinder R, Buckle G, Budke CM, Burch M, Burney P, Burstein R, Calabria B, Campbell B, Canter CE, Carabin H, Carapetis J, Carmona L, Cella C, Charlson F, Chen H, Cheng AT-A, Chou D, Chugh SS, Coffeng LE, Colan SD, Colquhoun S, Colson KE, Condon J, Connor MD, Cooper LT, Corriere M, Cortinovis M, De Vaccaro KC, Couser W, Cowie BC, Criqui MH, Cross M, Dabhadkar KC, Dahiya M, Dahodwala N, Damsere-Derry J, Danaei G, Davis A, De Leo D, Degenhardt L, Dellavalle R, Delossantos A, Denenberg J, Derrett S, Des Jarlais DC, Dharmaratne SD, Dherani M, Diaz-Torne C, Dolk H, Dorsey ER, Driscoll T, Duber H, Ebel B, Edmond K, Elbaz A, Ali SE, Erskine H, Erwin PJ, Espindola P, Ewoigbokhan SE, Farzadfar F, Feigin V, Felson DT, Ferrari A, Ferri CP, Fevre EM, Finucane MM, Flaxman S, Flood L, Foreman K, Forouzanfar MH, Fowkes FGR, Fransen M, Freeman MK, Gabbe BJ, Gabriel SE, Gakidou E, Ganatra HA, Garcia B, Gaspari F, Gillum RF, Gmel G, Gonzalez-Medina D, Gosselin R, Grainger R, Grant B, Groeger J, Guillemin F, Gunnell D, Gupta R, Haagsma J, Hagan H, Halasa YA, Hall W, Haring D, Maria Haro J, Harrison JE, Havmoeller R, Hay RJ, Higashi H, Hill C, Hoen B, Hoffman H, Hotez PJ, Hoy D, Huang JJ, Ibeanusi SE, Jacobsen KH, James SL, Jarvis D, Jasrasaria R, Jayaraman S, Johns N, Jonas JB, Karthikeyan G, Kassebaum N, Kawakami N, Keren A, Khoo J-P, King CH, Knowlton LM, Kobusingye O, Koet al., 2012, Disability-adjusted life years (DALYs) for 291 diseases and injuries in 21 regions, 1990-2010: a systematic analysis for the Global Burden of Disease Study 2010, LANCET, Vol: 380, Pages: 2197-2223, ISSN: 0140-6736

Journal article

Vos T, Flaxman AD, Naghavi M, Lozano R, Michaud C, Ezzati M, Shibuya K, Salomon JA, Abdalla S, Aboyans V, Abraham J, Ackerman I, Aggarwal R, Ahn SY, Ali MK, Alvarado M, Anderson HR, Anderson LM, Andrews KG, Atkinson C, Baddour LM, Bahalim AN, Barker-Collo S, Barrero LH, Bartels DH, Basanez M-G, Baxter A, Bell ML, Benjamin EJ, Bennett D, Bernabe E, Bhalla K, Bhandari B, Bikbov B, Bin Abdulhak A, Birbeck G, Black JA, Blencowe H, Blore JD, Blyth F, Bolliger I, Bonaventure A, Boufous SA, Bourne R, Boussinesq M, Braithwaite T, Brayne C, Bridgett L, Brooker S, Brooks P, Brugha TS, Bryan-Hancock C, Bucello C, Buchbinder R, Buckle GR, Budke CM, Burch M, Burney P, Burstein R, Calabria B, Campbell B, Canter CE, Carabin H, Carapetis J, Carmona L, Cella C, Charlson F, Chen H, Cheng AT-A, Chou D, Chugh SS, Coffeng LE, Colan SD, Colquhoun S, Colson KE, Condon J, Connor MD, Cooper LT, Corriere M, Cortinovis M, de Vaccaro KC, Couser W, Cowie BC, Criqui MH, Cross M, Dabhadkar KC, Dahiya M, Dahodwala N, Damsere-Derry J, Danaei G, Davis A, De Leo D, Degenhardt L, Dellavalle R, Delossantos A, Denenberg J, Derrett S, Des Jarlais DC, Dharmaratne SD, Dherani M, Diaz-Torne C, Dolk H, Dorsey ER, Driscoll T, Duber H, Ebel B, Edmond K, Elbaz A, Ali SE, Erskine H, Erwin PJ, Espindola P, Ewoigbokhan SE, Farzadfar F, Feigin V, Felson DT, Ferrari A, Ferri CP, Fevre EM, Finucane MM, Flaxman S, Flood L, Foreman K, Forouzanfar MH, Fowkes FGR, Franklin R, Fransen M, Freeman MK, Gabbe BJ, Gabriel SE, Gakidou E, Ganatra HA, Garcia B, Gaspari F, Gillum RF, Gmel G, Gosselin R, Grainger R, Groeger J, Guillemin F, Gunnell D, Gupta R, Haagsma J, Hagan H, Halasa YA, Hall W, Haring D, Maria Haro J, Harrison JE, Havmoeller R, Hay RJ, Higashi H, Hill C, Hoen B, Hoffman H, Hotez PJ, Hoy D, Huang JJ, Ibeanusi SE, Jacobsen KH, James SL, Jarvis D, Jasrasaria R, Jayaraman S, Johns N, Jonas JB, Karthikeyan G, Kassebaum N, Kawakami N, Keren A, Khoo J-P, King CH, Knowlton LM, Kobusingye O, Koranteng A, Krishnamurthi Ret al., 2012, Years lived with disability (YLDs) for 1160 sequelae of 289 diseases and injuries 1990-2010: a systematic analysis for the Global Burden of Disease Study 2010, LANCET, Vol: 380, Pages: 2163-2196, ISSN: 0140-6736

Journal article

Basanez M-G, McCarthy JS, French MD, Yang G-J, Walker M, Gambhir M, Prichard RK, Churcher TSet al., 2012, A Research Agenda for Helminth Diseases of Humans: Modelling for Control and Elimination, PLOS Neglected Tropical Diseases, Vol: 6, ISSN: 1935-2735

Human helminthiases are of considerable publichealth importance in sub-Saharan Africa, Asia, and LatinAmerica. The acknowledgement of the disease burden dueto helminth infections, the availability of donated oraffordable drugs that are mostly safe and moderatelyefficacious, and the implementation of viable mass drugadministration (MDA) interventions have prompted theestablishment of various large-scale control and eliminationprogrammes. These programmes have benefited fromimproved epidemiological mapping of the infections, betterunderstanding of the scope and limitations of currentlyavailable diagnostics and of the relationship betweeninfection and morbidity, feasibility of community-directedor school-based interventions, and advances in the design ofmonitoring and evaluation (M&E) protocols. Considerablesuccess has been achieved in reducing morbidity orsuppressing transmission in a number of settings, whilstchallenges remain in many others. Some of the obstaclesinclude the lack of diagnostic tools appropriate to thechanging requirements of ongoing interventions andelimination settings; the reliance on a handful of drugsabout which not enough is known regarding modes ofaction, modes of resistance, and optimal dosage singly or incombination; the difficulties in sustaining adequate coverageand compliance in prolonged and/or integrated programmes;an incomplete understanding of the social,behavioural, and environmental determinants of infection;and last, but not least, very little investment in research anddevelopment (R&D). The Disease Reference Group onHelminth Infections (DRG4), established in 2009 by theSpecial Programme for Research and Training in TropicalDiseases (TDR), was given the mandate to undertake acomprehensive review of recent advances in helminthiasesresearch, identify research gaps, and rank priorities for anR&D agenda for the control and elimination of theseinfections. This review presents the processes undertakento identify and rank ten t

Journal article

Osei-Atweneboana MY, Lustigman S, Prichard RK, Boatin BA, Basanez M-Get al., 2012, A Research Agenda for Helminth Diseases of Humans: Health Research and Capacity Building in Disease-Endemic Countries for Helminthiases Control, PLOS NEGLECTED TROPICAL DISEASES, Vol: 6, ISSN: 1935-2735

Journal article

Prichard RK, Basanez M-G, Boatin BA, McCarthy JS, Garcia HH, Yang G-J, Sripa B, Lustigman Set al., 2012, A Research Agenda for Helminth Diseases of Humans: Intervention for Control and Elimination, PLOS NEGLECTED TROPICAL DISEASES, Vol: 6, ISSN: 1935-2735

Journal article

Lustigman S, Prichard RK, Gazzinelli A, Grant WN, Boatin BA, McCarthy JS, Basanez M-Get al., 2012, A Research Agenda for Helminth Diseases of Humans: The Problem of Helminthiases, PLOS NEGLECTED TROPICAL DISEASES, Vol: 6, ISSN: 1935-2735

Journal article

Lustigman S, Geldhof P, Grant WN, Osei-Atweneboana MY, Sripa B, Basanez M-Get al., 2012, A Research Agenda for Helminth Diseases of Humans: Basic Research and Enabling Technologies to Support Control and Elimination of Helminthiases, PLOS NEGLECTED TROPICAL DISEASES, Vol: 6, ISSN: 1935-2735

Journal article

McCarthy JS, Lustigman S, Yang G-J, Barakat RM, Garcia HH, Sripa B, Willingham AL, Prichard RK, Basanez M-Get al., 2012, A Research Agenda for Helminth Diseases of Humans: Diagnostics for Control and Elimination Programmes, PLOS NEGLECTED TROPICAL DISEASES, Vol: 6, ISSN: 1935-2735

Journal article

Basanez M-G, French MD, Walker M, Churcher TSet al., 2012, Paradigm lost: how parasite control may alter pattern and process in human helminthiases, TRENDS IN PARASITOLOGY, Vol: 28, Pages: 161-171, ISSN: 1471-4922

Journal article

Walker M, Little MP, Wagner KS, Soumbey-Alley EW, Boatin BA, Basáñez M-Get al., 2012, Density-Dependent Mortality of the Human Host in Onchocerciasis: Relationships between Microfilarial Load and Excess Mortality, PLoS Neglected Tropical Diseases, Vol: 6

Journal article

Basáñez MG, McCarthy JS, French MD, Yang GY, Walker M, Prichard RK, Churcher TSet al., 2012, A Research Agenda for Helminth Diseases of Humans: Modelling for Control and Elimination, PLoS Neglected Tropical Diseases, Vol: 6

Journal article

Crainey JL, Hurst J, Basanez M-G, Lamberton P, Griffin C, Cheke R, Wilson M, Post Ret al., 2011, <i>Simulium damnosum wolbachia</i> (Wsdam) genomes harbor WOcauB2/B3-like bacteriophage, Publisher: WILEY-BLACKWELL, Pages: 202-202, ISSN: 1360-2276

Conference paper

Green HK, Sousa-Figueiredo JC, Basanez M-G, Betson M, Kabatereine NB, Fenwick A, Stothard JRet al., 2011, Anaemia in Ugandan preschool-aged children: the relative contribution of intestinal parasites and malaria, PARASITOLOGY, Vol: 138, Pages: 1534-1545, ISSN: 0031-1820

Journal article

White MT, Griffin JT, Churcher TS, Ferguson NM, Basanez MG, Ghani ACet al., 2011, Modelling the impact of vector control interventions on Anopheles gambiae population dynamics, Parasites & Vectors, Vol: 4, ISSN: 1756-3305

BACKGROUND:Intensive anti-malaria campaigns targeting the Anopheles population have demonstrated substantial reductions in adult mosquito density. Understanding the population dynamics of Anopheles mosquitoes throughout their whole lifecycle is important to assess the likely impact of vector control interventions alone and in combination as well as to aid the design of novel interventions.METHODS:An ecological model of Anopheles gambiae sensu lato populations incorporating a rainfall-dependent carrying capacity and density-dependent regulation of mosquito larvae in breeding sites is developed. The model is fitted to adult mosquito catch and rainfall data from 8 villages in the Garki District of Nigeria (the 'Garki Project') using Bayesian Markov Chain Monte Carlo methods and prior estimates of parameters derived from the literature. The model is used to compare the impact of vector control interventions directed against adult mosquito stages--long-lasting insecticide treated nets (LLIN), indoor residual spraying (IRS)-- and directed against aquatic mosquito stages, alone and in combination on adult mosquito density.RESULTS:A model in which density-dependent regulation occurs in the larval stages via a linear association between larval density and larval death rates provided a good fit to seasonal adult mosquito catches. The effective mosquito reproduction number in the presence of density-dependent regulation is dependent on seasonal rainfall patterns and peaks at the start of the rainy season. In addition to killing adult mosquitoes during the extrinsic incubation period, LLINs and IRS also result in less eggs being oviposited in breeding sites leading to further reductions in adult mosquito density. Combining interventions such as the application of larvicidal or pupacidal agents that target the aquatic stages of the mosquito lifecycle with LLINs or IRS can lead to substantial reductions in adult mosquito density.CONCLUSIONS:Density-dependent regulation of anophel

Journal article

Koukounari A, Toure S, Donnelly CA, Ouedraogo A, Yoda B, Ky C, Kabore M, Bosque-Oliva E, Basanez M-G, Fenwick A, Webster JPet al., 2011, Integrated monitoring and evaluation and environmental risk factors for urogenital schistosomiasis and active trachoma in Burkina Faso before preventative chemotherapy using sentinel sites, BMC INFECTIOUS DISEASES, Vol: 11, ISSN: 1471-2334

Background: Over 1 billion of the world’s poorest inhabitants are afflicted by neglected tropical diseases (NTDs).Integrated control programmes aimed at tackling these debilitating NTDs have been recently initiated, mainlyusing preventative chemotherapy. Monitoring and evaluation (M&E) of these integrated programs presentsparticular challenges over and above those required for single disease vertical programmes. We used baseline datafrom the National NTD Control Programme in Burkina Faso in order to assess the feasibility of an integrated surveydesign, as well as to elucidate the contribution of environmental variables to the risk of either Schistosomahaematobium, trachoma, or both among school-aged children.Methods: S. haematobium infection was diagnosed by detecting eggs in urine. A trachoma case was defined bythe presence of Trachomatous inflammation-Follicular (TF) and/or Trachomatous inflammation-Intense (TI) in eithereye. Baseline data collected from 3,324 children aged 7-11 years in 21 sentinel sites across 11 regions of BurkinaFaso were analyzed using simple and multivariable hierarchical binomial logistic regression models fitted byMarkov Chain Monte Carlo estimation methods. Probabilities of the risk of belonging to each infection/diseasecategory were estimated as a function of age, gender (individual level), and environmental variables (at sentinelsite level, interpolated from national meteorological stations).Results: Overall prevalence at the sentinel sites was 11.79% (95% CI: 10.70-12.89) for S. haematobium; 13.30%(12.14-14.45) for trachoma and 0.84% (0.53-1.15) for co-infections. The only significant predictor of S. haematobiuminfection was altitude. There were significant negative associations between the prevalence of active trachomasigns and minimum temperature, and air pressure. Conditional upon these predictors, these data are consistentwith the two pathogens being independent.Conclusions: Urogenital schistosomiasis and trachoma constit

Journal article

Walker M, Hall A, Basanez M-G, 2011, Individual Predisposition, Household Clustering and Risk Factors for Human Infection with <i>Ascaris lumbricoides</i>: New Epidemiological Insights, PLOS NEGLECTED TROPICAL DISEASES, Vol: 5, ISSN: 1935-2735

Journal article

Gambhir M, Basanez MG, Blake IM, Grassly Net al., 2010, Modelling trachoma for control programmes, Modelling Parasite Transmission and Control, Editors: Michael, Spear, Publisher: Austin, Texas: Landes Bioscience, ISBN: 9781441960641

Book chapter

Churcher TS, Dawes EJ, Sinden RE, Christophides GK, Koella JC, Basanez M-Get al., 2010, Population biology of malaria within the mosquito: density-dependent processes and potential implications for transmission-blocking interventions, MALARIA JOURNAL, Vol: 9, ISSN: 1475-2875

Journal article

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