Publications
272 results found
Basanez M-G, Pion SDS, Boakes E, et al., 2008, Effect of single-dose ivermectin on <i>Onchocerca volvulus</i>:: a systematic review and meta-analysis, LANCET INFECTIOUS DISEASES, Vol: 8, Pages: 310-322, ISSN: 1473-3099
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- Citations: 136
Churcher TS, Schwab AE, Prichard RK, et al., 2008, An Analysis of Genetic Diversity and Inbreeding in <i>Wuchereria bancrofti</i>: Implications for the Spread and Detection of Drug Resistance, PLOS NEGLECTED TROPICAL DISEASES, Vol: 2, ISSN: 1935-2735
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- Citations: 26
Churcher TS, Basanez M-G, 2008, Density dependence and the spread of anthelmintic resistance, EVOLUTION, Vol: 62, Pages: 528-537, ISSN: 0014-3820
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- Citations: 38
Rudge JW, Stothard JR, Basanez M-G, et al., 2008, Micro-epidemiology of urinary schistosomiasis in Zanzibar:: Local risk factors associated with distribution of infections among schoolchildren and relevance for control, ACTA TROPICA, Vol: 105, Pages: 45-54, ISSN: 0001-706X
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- Citations: 85
Rodríguez-Pérez MA, Cabrera AS, Ortega CL, et al., 2007, Contribution of migrant coffee labourers infected with Onchocerca volvulus to the maintenance of the microfilarial reservoir in an ivermectin-treated area of Mexico., Filaria J, Vol: 6
BACKGROUND: Since 1991, in Mexico, ivermectin has been administered twice a year to all residents in the onchocerciasis endemic foci which are mainly located in the coffee growing areas. However, the presence of a potentially infected itinerant seasonal labour force which is not treated regularly could jeopardise the attainment of the 85% coverage which is the present target for elimination of the disease. METHODS: The prevalence and intensity of Onchocerca volvulus microfilariae (mf), as well as their transmission from humans to vectors, were assessed during the coffee planting-clearing and harvesting seasons of 1997-1998, and 1998-1999 in two localities (I and II) of Southern Chiapas, Mexico, which regularly receive an influx of untreated migrant coffee labourers. RESULTS: Localities I and II had, respectively, an average of 391 (+/- 32) and 358 (+/- 14) resident inhabitants, and 70 (+/- 52) and 498 (+/- 289) temporary labourers. The ratio of migrants to residents ranged from 0.1:1 in locality I to 2.4:1 in locality II. The proportion of infected Simulium ochraceum s.l. parous flies was significantly lower in locality I than in locality II, and significantly higher during the stay of the migrants than before their arrival or after their departure. Parity and infection were higher in May-July than in November-February (in contrast with the latter being typically considered as the peak onchocerciasis transmission season by S. ochraceum s.l.). CONCLUSION: The presence of significant numbers of untreated and potentially infected migrants may contribute to ongoing transmission, and their incorporation into ivermectin programmes should be beneficial for the attainment of the elimination goals of the regional initiative. However, the possibility that the results also reflect transmission patterns for the area cannot be excluded and these should be analyzed further.
Sinden RE, Dawes EJ, Alavi Y, et al., 2007, Progression of <i>Plasmodium berghei</i> through <i>Anopheles stephensi</i> is density-dependent, PLOS PATHOGENS, Vol: 3, Pages: 2005-2016, ISSN: 1553-7366
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- Citations: 101
French MD, Rollinson D, Basáñez M-G, et al., 2007, School-based control of urinary schistosomiasis on Zanzibar, Tanzania: monitoring micro-haematuria with reagent strips as a rapid urological assessment., J Pediatr Urol, Vol: 3, Pages: 364-368
OBJECTIVE: To evaluate micro-haematuria, detected by Haemastix reagent strips, for diagnosis of urinary schistosomiasis during a 3-year period of school-based control on Zanzibar. PATIENTS AND METHODS: A sub-set of school children, from a total of 135,000 who were receiving treatment for urinary schistosomiasis and soil-transmitted helminthiasis, were monitored by parasitological and questionnaire methods for Schistosoma haematobium infections: at treatment baseline in 2004 (n=2002), follow up with re-treatment in 2005 (n=3278) and further follow up with re-treatment in 2006 (n=3993). Standard diagnostic scores for micro-haematuria were calculated against parasitological assessment. RESULTS: Diagnostic scores of Haemastix remained strong throughout the 3-year period. In 2006, scores were: sensitivity (SS)=0.86 (95% CI: 0.86-0.88), specificity (SP)=0.99 (0.98-1.00), positive predictive value (PPV)=0.90 (0.88-0.91), negative predictive value (NPV)=0.98 (0.98-0.99) in boys; and SS=0.84 (0.82-0.86), SP=0.98 (0.98-0.99), PPV=0.77 (0.75-0.79) and NPV=0.99 (0.99-1.00) in girls. By comparison, reported blood in urine and pain upon urination were much lower and not as informative. CONCLUSION: At a cost of approximately pound sterling 0.20/test, further use of reagent strips for monitoring of urinary schistosomiasis during ongoing control programmes should be advocated as a rapid, cost-effective and informative disease surveillance tool.
Schwab AE, Churcher TS, Schwab AJ, et al., 2007, An analysis of the population genetics of potential multi-drug resistance in <i>Wuchereria bancrofti</i> due to combination chemotherapy, PARASITOLOGY, Vol: 134, Pages: 1025-1040, ISSN: 0031-1820
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- Citations: 46
Wetten S, Collins RC, Vieira JC, et al., 2007, Vector competence for <i>Onchocerca volvulus</i> in the Simulium (<i>Notolepria</i>) <i>exiguum</i> complex:: Cytoforms or density-dependence?, ACTA TROPICA, Vol: 103, Pages: 58-68, ISSN: 0001-706X
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- Citations: 8
Gambhir M, Basanez M-G, Turner F, et al., 2007, Trachoma:: transmission, infection, and control, LANCET INFECTIOUS DISEASES, Vol: 7, Pages: 420-427, ISSN: 1473-3099
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- Citations: 40
Basanez M-G, Razali K, Renz A, et al., 2007, Density-dependent host choice by disease vectors:: epidemiological implications of the ideal free distribution, TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE, Vol: 101, Pages: 256-269, ISSN: 0035-9203
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- Citations: 22
Bottomley C, Isham V, Basanez M-G, 2007, Population biology of multispecies helminth infection:: Competition and coexistence, JOURNAL OF THEORETICAL BIOLOGY, Vol: 244, Pages: 81-95, ISSN: 0022-5193
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- Citations: 11
Vivas-Martínez S, Grillet ME, Botto C, et al., 2007, Human onchocerciasis in the Amazonian focus, Boletin de Malariologia y Salud Ambiental, Vol: 47, Pages: 15-46, ISSN: 1690-4648
In this article we describe human onchocerciasis affecting Yanomami people in the Amazonian focus of southern Venezuela and review recent knowledge about the disease and its control. The epidemiology of this parasitic infection (caused by Onchocerca volvulus and transmitted by Simulium vectors), is highly dependent on the environmental and entomological characteristics prevalent in the region, which are in turn determined by altitudinal, vegetational and geological gradients. Similarly, sociocultural and demographic characteristics of the Yanomami people play an important roll in the exposure to the vector and the transmission levels of the parasite. Communities with higher infection intensity and transmission (hyperendemic) are located at higher altitudes, characterized by high parasite burden, ocular and dermatological lesions, and additionally a deep suppression of the immunological response to parasite antigens. The proportion of hyperendemic communities reaches 60% of communities stratified so far; however, risk maps using geographical information systems suggest that this proportion may be higher. The onchocerciasis elimination programme is based on mass ivermectin distribution twice a year to at least 85% of the eligible population. Despite difficulties in achieving this goal, mainly caused by the remoteness of the communities, the impact of several rounds of treatment is an improvement on the parasitological and clinical indicators in the Yanomami population included in the programme. Finally, we discuss recent guidelines of epidemiological surveillances of the disease and describe new therapeutical approaches for onchocerciasis control.
Vivas-Martínez S, Grillet ME, Botto C, et al., 2007, [Human onchocerciasis in the Amazonian focus], Boletín de Malariología y Salud Ambiental, Vol: 47, Pages: 15-46
Churcher TS, Filipe JAN, Basanez M-G, 2006, Density dependence and the control of helminth parasites, JOURNAL OF ANIMAL ECOLOGY, Vol: 75, Pages: 1313-1320, ISSN: 0021-8790
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- Citations: 44
Schwab AE, Churcher TS, Schwab AJ, et al., 2006, Population genetics of concurrent selection with albendazole and ivermectin or diethylcarbamazine on the possible spread of albendazole resistance in <i>Wuchereria bancrofti</i>, PARASITOLOGY, Vol: 133, Pages: 589-601, ISSN: 0031-1820
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- Citations: 31
Basanez M-G, Pion SDS, Churcher TS, et al., 2006, River blindness:: A success story under threat?, PLOS MEDICINE, Vol: 3, Pages: 1454-1460, ISSN: 1549-1277
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- Citations: 157
Pion SDS, Filipe JAN, Kamgno J, et al., 2006, Microfilarial distribution of <i>Loa loa</i> in the human host:: population dynamics and epidemiological implications, PARASITOLOGY, Vol: 133, Pages: 101-109, ISSN: 0031-1820
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- Citations: 17
Pion SDS, Clarke P, Filipe JAN, et al., 2006, Co-infection with <i>Onchocerca volvulus</i> and <i>Loa loa</i> microfilariae in central Cameroon:: are these two species interacting, PARASITOLOGY, Vol: 132, Pages: 843-854, ISSN: 0031-1820
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- Citations: 18
Filipe JAN, Boussinesq M, Renz A, et al., 2005, Human infection patterns and heterogeneous exposure in river blindness, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Vol: 102, Pages: 15265-15270, ISSN: 0027-8424
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- Citations: 68
Bottomley C, Isham V, Basáñez MG, 2005, Population biology of multispecies helminth infection:: interspecific interactions and parasite distribution, PARASITOLOGY, Vol: 131, Pages: 417-433, ISSN: 0031-1820
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- Citations: 25
Churcher TS, Ferguson NM, Basáñez MG, 2005, Density dependence and overdispersion in the transmission of helminth parasites, PARASITOLOGY, Vol: 131, Pages: 121-132, ISSN: 0031-1820
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- Citations: 55
Grillet ME, Villamizar NJ, Cortez J, et al., 2005, Diurnal biting periodicity of parous <i>Simulium</i> (Diptera: Simuliidae) vectors in the onchocerciasis Amazonian focus, ACTA TROPICA, Vol: 94, Pages: 139-158, ISSN: 0001-706X
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- Citations: 13
Vieira JC, Brackenboro L, Porter CH, et al., 2005, Spatial and temporal variation in biting rates and parasite transmission potentials of onchocerciasis vectors in Ecuador, TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE, Vol: 99, Pages: 178-195, ISSN: 0035-9203
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- Citations: 14
Bradley JE, Whitworth J, Basanez MG, 2005, Onchocerciasis, Topley and Wilson’s Microbiology and Microbial Infections 10th edition (Parasitology Volume), Editors: Cox, Wakelin, Gillespie, Despommier, Publisher: London: Edward Arnold Publishers Ltd., Pages: 781-801
Bradley JE, Whitworth J, Basáñez MG, 2005, Onchocerciasis, Topley and Wilson's Microbiology and Microbial Infections 10th ed., Editors: Wakelin, Cox, Despommier, Gillespie, Publisher: Edward Arnold Publishers Ltd.
Basáñez MG, 2005, [Epidemiology, control, and evolution of helminthic disease: River Blindness as a case study], Acta Biologica Venezuelica, Vol: 25, Pages: 19-42
Basáñez MG, Rodríguez DJ, 2004, Dinámica de transmisión y modelos matemáticos en enfermedadestransmitidas por vectores, Entomotropica, Vol: 19, Pages: 113-134, ISSN: 1317-5262
Modern theory on the dynamics of infectious diseases is infl uenced by ecological theory, especially by demography. Th e study of these dynamicsusing mathematical models has had a staggering development in recent years, and has proven to be a valuable tool to understand epidemiologicalpatterns and processes, provided that models are as close as possible to real life situations and based on biological knowledge. We discuss thebasic concepts of the transmission dynamics of infectious agents aff ecting a host and an insect vector. We specifi cally study mathematicalmodels for the dynamics of human malaria in both spatially homogeneous and fragmented environments. Models for the dynamics of humanonchocerciasis are also presented. Finally we discuss the results and their basic and applied importance.
Ottesen EA, Weil GJ, Lammie PJ, et al., 2004, Towards a strategic plan for research to support the global program to eliminate lymphatic filariasis - Summary of immediate needs and opportunities for research on lymphatic filariasis identified by the Filariasis community of scientists in association with an "LF research forum", convened in Philadelphia, December 9-10, 2003, AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE, Vol: 71, Pages: 1-46, ISSN: 0002-9637
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- Citations: 15
Little MP, Basáñez MG, Breitling LP, et al., 2004, Incidence of blindness during the Onchocerciasis Control Programme in western Africa, 1971-2002, JOURNAL OF INFECTIOUS DISEASES, Vol: 189, Pages: 1932-1941, ISSN: 0022-1899
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- Citations: 30
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