Imperial College London
Alternate

ProfessorMaria-GloriaBasanez

Faculty of Medicine, School of Public Health

Professor of Neglected Tropical Diseases
 
 
 
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Contact

 

+44 (0)20 7594 3295m.basanez Website

 
 
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Location

 

503School of Public HealthWhite City Campus

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Summary

 

Publications

Citation

BibTex format

@article{Walker:2021:cid/ciab350,
author = {Walker, M and Hamley, J and Milton, P and Kinrade, S and Monnot, F and Specht, S and Pedrique, B and Basanez, M-G},
doi = {cid/ciab350},
journal = {Clinical Infectious Diseases},
pages = {e1391--e1396},
title = {Supporting drug development for neglected tropical diseases using mathematical modelling},
url = {http://dx.doi.org/10.1093/cid/ciab350},
volume = {73},
year = {2021}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Drug-based interventions are at the heart of global efforts to reach elimination as a public health problem (trachoma, soil-transmitted helminthiases, schistosomiasis, lymphatic filariasis) or elimination of transmission (onchocerciasis) for five of the most prevalent neglected tropical diseases tackled via the World Health Organization preventive chemotherapy strategy. While for some of these diseases there is optimism that currently available drugs will be sufficient to achieve the proposed elimination goals, for others—particularly onchocerciasis—there is a growing consensus that novel therapeutic options will be needed. Since in this area no high return of investment is possible, minimizing wasted money and resources is essential. Here, we use illustrative results to show how mathematical modelling can guide the drug development pathway, yielding resource-saving and efficiency payoffs, from the refinement of target product profiles and intended context of use, to the design of clinical trials.
AU  - Walker,M
AU  - Hamley,J
AU  - Milton,P
AU  - Kinrade,S
AU  - Monnot,F
AU  - Specht,S
AU  - Pedrique,B
AU  - Basanez,M-G
DO  - cid/ciab350
EP  - 1396
PY  - 2021///
SN  - 1058-4838
SP  - 1391
TI  - Supporting drug development for neglected tropical diseases using mathematical modelling
T2  - Clinical Infectious Diseases
UR  - http://dx.doi.org/10.1093/cid/ciab350
UR  - https://academic.oup.com/cid/advance-article/doi/10.1093/cid/ciab350/6248449
UR  - http://hdl.handle.net/10044/1/89361
VL  - 73
ER  -
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