Imperial College London
Alternate

ProfessorMaria-GloriaBasanez

Faculty of Medicine, School of Public Health

Professor of Neglected Tropical Diseases
 
 
 
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Contact

 

+44 (0)20 7594 3295m.basanez Website

 
 
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Location

 

503School of Public HealthWhite City Campus

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Summary

 

Publications

Citation

BibTex format

@article{Jewell:2021:10.1111/tmi.13652,
author = {Jewell, PD and Abraham, A and Schmidt, V and Buell, KG and Bustos, JA and Garcia, HH and Dixon, MA and Walker, M and Ngowi, BJ and Basáñez, M-G and Winkler, AS},
doi = {10.1111/tmi.13652},
journal = {Tropical Medicine and International Health},
pages = {1140--1152},
title = {Neurocysticercosis and HIV/AIDS co-infection: a scoping review},
url = {http://dx.doi.org/10.1111/tmi.13652},
volume = {26},
year = {2021}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - OBJECTIVES: Neurocysticercosis (NCC) and human immunodeficiency virus (HIV) have high disease burden and are prevalent in overlapping low- and middle-income areas. Yet, treatment guidance for people living with HIV/AIDS (PLWH/A) co-infected with NCC is currently lacking. This study aims to scope the available literature on HIV/AIDS and NCC co-infection, focusing on epidemiology, clinical characteristics, diagnostics, and treatment outcomes. METHODS: The scoping literature review methodological framework, and the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines were followed. A total of 16,969 records identified through database searching and 45 additional records from other sources were reduced to 52 included studies after a standardised selection process. RESULTS: Two experimental studies, ten observational studies, 23 case series/case reports and 17 reviews or letters were identified. Observational studies demonstrated similar NCC seroprevalence in PLWH/A and their HIV-negative counterparts. Of 29 PLWH/A and NCC co-infection, 17 (59%) suffered from epileptic seizures, 15 (52%) from headaches, and 15 (52%) had focal neurological deficits. Eighteen (62%) had viable vesicular cysts and six (21%) had calcified cysts. Fifteen (52%) were treated with albendazole, of which 11 (73%) responded well to treatment. Five individuals potentially demonstrated an immune-reconstitution inflammatory syndrome after commencing anti-retroviral therapy, although this was in the absence of immunological and neuroimaging confirmation. CONCLUSIONS: There is a paucity of evidence to guide treatment of PLWH/A and NCC co-infection. There is a pressing need for high-quality studies in this patient group to appropriately inform diagnostic and management guidelines for HIV-positive patients with NCC.
AU  - Jewell,PD
AU  - Abraham,A
AU  - Schmidt,V
AU  - Buell,KG
AU  - Bustos,JA
AU  - Garcia,HH
AU  - Dixon,MA
AU  - Walker,M
AU  - Ngowi,BJ
AU  - Basáñez,M-G
AU  - Winkler,AS
DO  - 10.1111/tmi.13652
EP  - 1152
PY  - 2021///
SN  - 1360-2276
SP  - 1140
TI  - Neurocysticercosis and HIV/AIDS co-infection: a scoping review
T2  - Tropical Medicine and International Health
UR  - http://dx.doi.org/10.1111/tmi.13652
UR  - https://www.ncbi.nlm.nih.gov/pubmed/34228854
UR  - https://onlinelibrary.wiley.com/doi/10.1111/tmi.13652
UR  - http://hdl.handle.net/10044/1/90414
VL  - 26
ER  -
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