Imperial College London
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DrMorganBeeby

Faculty of Natural Sciences, Department of Life Sciences

Reader in Structural Biology
 
 
 
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Contact

 

m.beeby Website

 
 
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Location

 

502Sir Ernst Chain BuildingSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Thomson:2018:10.1371/journal.pone.0206544,
author = {Thomson, NM and Ferreira, JL and Matthews-Palmer, TR and Beeby, M and Pallen, MJ},
doi = {10.1371/journal.pone.0206544},
journal = {PLoS ONE},
title = {Giant flagellins form thick flagellar filaments in two species of marine gamma-proteobacteria},
url = {http://dx.doi.org/10.1371/journal.pone.0206544},
volume = {13},
year = {2018}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Flagella, the primary means of motility in bacteria, are helical filaments that function as microscopic propellers composed of thousands of copies of the protein flagellin. Here, we show that many bacteria encode “giant” flagellins, greater than a thousand amino acids in length, and that two species that encode giant flagellins, the marine γ-proteobacteria Bermanella marisrubri and Oleibacter marinus, produce monopolar flagellar filaments considerably thicker than filaments composed of shorter flagellin monomers. We confirm that the flagellum from B. marisrubri is built from its giant flagellin. Phylogenetic analysis reveals that the mechanism of evolution of giant flagellins has followed a stepwise process involving an internal domain duplication followed by insertion of an additional novel insert. This work illustrates how “the” bacterial flagellum should not be seen as a single, idealised structure, but as a continuum of evolved machines adapted to a range of niches.
AU  - Thomson,NM
AU  - Ferreira,JL
AU  - Matthews-Palmer,TR
AU  - Beeby,M
AU  - Pallen,MJ
DO  - 10.1371/journal.pone.0206544
PY  - 2018///
SN  - 1932-6203
TI  - Giant flagellins form thick flagellar filaments in two species of marine gamma-proteobacteria
T2  - PLoS ONE
UR  - http://dx.doi.org/10.1371/journal.pone.0206544
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000451054800019&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - http://hdl.handle.net/10044/1/65570
VL  - 13
ER  -
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