Imperial College London
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DrMorganBeeby

Faculty of Natural Sciences, Department of Life Sciences

Reader in Structural Biology
 
 
 
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Contact

 

m.beeby Website

 
 
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Location

 

502Sir Ernst Chain BuildingSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Cohen:2020:10.1371/journal.ppat.1008620,
author = {Cohen, EJ and Nakane, D and Kabata, Y and Hendrixson, DR and Nishizaka, T and Beeby, M},
doi = {10.1371/journal.ppat.1008620},
journal = {PLoS Pathogens},
pages = {1--24},
title = {Campylobacter jejuni motility integrates specialized cell shape, flagellar filament, and motor, to coordinate action of its opposed flagella},
url = {http://dx.doi.org/10.1371/journal.ppat.1008620},
volume = {16},
year = {2020}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Campylobacter jejuni rotates a flagellum at each pole to swim through the viscous mucosa of its hosts’ gastrointestinal tracts. Despite their importance for host colonization, however, how C. jejuni coordinates rotation of these two opposing flagella is unclear. As well as their polar placement, C. jejuni’s flagella deviate from the norm of Enterobacteriaceae in other ways: their flagellar motors produce much higher torque and their flagellar filament is made of two different zones of two different flagellins. To understand how C. jejuni’s opposed motors coordinate, and what contribution these factors play in C. jejuni motility, we developed strains with flagella that could be fluorescently labeled, and observed them by high-speed video microscopy. We found that C. jejuni coordinates its dual flagella by wrapping the leading filament around the cell body during swimming in high-viscosity media and that its differentiated flagellar filament and helical body have evolved to facilitate this wrapped-mode swimming.
AU  - Cohen,EJ
AU  - Nakane,D
AU  - Kabata,Y
AU  - Hendrixson,DR
AU  - Nishizaka,T
AU  - Beeby,M
DO  - 10.1371/journal.ppat.1008620
EP  - 24
PY  - 2020///
SN  - 1553-7366
SP  - 1
TI  - Campylobacter jejuni motility integrates specialized cell shape, flagellar filament, and motor, to coordinate action of its opposed flagella
T2  - PLoS Pathogens
UR  - http://dx.doi.org/10.1371/journal.ppat.1008620
UR  - https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1008620
UR  - http://hdl.handle.net/10044/1/80374
VL  - 16
ER  -
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