Imperial College London
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DrMorganBeeby

Faculty of Natural Sciences, Department of Life Sciences

Reader in Structural Biology
 
 
 
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m.beeby Website

 
 
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Location

 

502Sir Ernst Chain BuildingSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Taylor:2020:10.1016/j.ijpara.2020.05.008,
author = {Taylor, PJ and Hagen, J and Faruqu, FN and Al-Jamal, KT and Quigley, B and Beeby, M and Selkirk, ME and Sarkies, P},
doi = {10.1016/j.ijpara.2020.05.008},
journal = {International Journal for Parasitology},
pages = {697--705},
title = {Trichinella spiralis secretes abundant unencapsulated small RNAs with potential effects on host gene expression},
url = {http://dx.doi.org/10.1016/j.ijpara.2020.05.008},
volume = {50},
year = {2020}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Many organisms, including parasitic nematodes, secrete small RNAs into the extracellular environment, largely encapsulated within small vesicles. Parasite-secreted material often contains microRNAs (miRNAs), raising the possibility that they might regulate host genes in target cells. Here we characterise secreted RNAs from the parasitic nematode Trichinella spiralis at two different life stages. We show that adult T. spiralis, which inhabit intestinal mucosa, secrete miRNAs within vesicles. Unexpectedly, T. spiralis muscle stage larvae, which live intracellularly within skeletal muscle cells, secrete miRNAs that appear not to be encapsulated. Notably, secreted miRNAs include a homologue of mammalian miRNA-31, which has an important role in muscle development. Our work therefore suggests that RNAs may be secreted without encapsulation in vesicles, with implications for the biology of T. spiralis infection.
AU  - Taylor,PJ
AU  - Hagen,J
AU  - Faruqu,FN
AU  - Al-Jamal,KT
AU  - Quigley,B
AU  - Beeby,M
AU  - Selkirk,ME
AU  - Sarkies,P
DO  - 10.1016/j.ijpara.2020.05.008
EP  - 705
PY  - 2020///
SN  - 0020-7519
SP  - 697
TI  - Trichinella spiralis secretes abundant unencapsulated small RNAs with potential effects on host gene expression
T2  - International Journal for Parasitology
UR  - http://dx.doi.org/10.1016/j.ijpara.2020.05.008
UR  - https://www.ncbi.nlm.nih.gov/pubmed/32622688
UR  - http://hdl.handle.net/10044/1/80760
VL  - 50
ER  -
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