Imperial College London
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DrMorganBeeby

Faculty of Natural Sciences, Department of Life Sciences

Reader in Structural Biology
 
 
 
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Contact

 

m.beeby Website

 
 
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Location

 

502Sir Ernst Chain BuildingSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Ferreira:2021:10.3389/fmicb.2021.643180,
author = {Ferreira, J and coleman, I and Addison, M and Zachs, T and Quigley, B and Wuichet, K and Beeby, M},
doi = {10.3389/fmicb.2021.643180},
journal = {Frontiers in Microbiology},
title = {The 'jack-of-all-trades' flagellum from Salmonella and E. coli was horizontally acquired from an ancestral beta-proteobacterium},
url = {http://dx.doi.org/10.3389/fmicb.2021.643180},
volume = {12},
year = {2021}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - The γ-proteobacteria are a group of diverse bacteria including pathogenic Escherichia, Salmonella, Vibrio, and Pseudomonas species. The majority swim in liquids with polar, sodium-driven flagella and swarm on surfaces with lateral, non-chemotactic flagella. Notable exceptions are the enteric Enterobacteriaceae such as Salmonella and E. coli. Many of the well-studied Enterobacteriaceae are gut bacteria that both swim and swarm with the same proton-driven peritrichous flagella. How different flagella evolved in closely related lineages, however, has remained unclear. Here, we describe our phylogenetic finding that Enterobacteriaceae flagella are not native polar or lateral γ-proteobacterial flagella but were horizontally acquired from an ancestral β-proteobacterium. Using electron cryo-tomography and subtomogram averaging, we confirmed that Enterobacteriaceae flagellar motors resemble contemporary β-proteobacterial motors and are distinct to the polar and lateral motors of other γ-proteobacteria. Structural comparisons support a model in which γ-proteobacterial motors have specialized, suggesting that acquisition of a β-proteobacterial flagellum may have been beneficial as a general-purpose motor suitable for adjusting to diverse conditions. This acquisition may have played a role in the development of the enteric lifestyle.
AU  - Ferreira,J
AU  - coleman,I
AU  - Addison,M
AU  - Zachs,T
AU  - Quigley,B
AU  - Wuichet,K
AU  - Beeby,M
DO  - 10.3389/fmicb.2021.643180
PY  - 2021///
SN  - 1664-302X
TI  - The 'jack-of-all-trades' flagellum from Salmonella and E. coli was horizontally acquired from an ancestral beta-proteobacterium
T2  - Frontiers in Microbiology
UR  - http://dx.doi.org/10.3389/fmicb.2021.643180
UR  - http://hdl.handle.net/10044/1/88488
VL  - 12
ER  -
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