Publications
411 results found
WARD JK, BELVISI MG, FOX AJ, et al., 1993, MODULATION OF CHOLINERGIC NEURAL BRONCHOCONSTRICTION BY ENDOGENOUS NITRIC-OXIDE AND VASOACTIVE-INTESTINAL-PEPTIDE IN HUMAN AIRWAYS IN-VITRO, JOURNAL OF CLINICAL INVESTIGATION, Vol: 92, Pages: 736-742, ISSN: 0021-9738
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- Citations: 136
BELVISI MG, PATACCHINI R, BARNES PJ, et al., 1993, FACILITATORY EFFECTS OF SELECTIVE AGONISTS FOR TACHYKININ RECEPTORS ON CHOLINERGIC NEUROTRANSMISSION, AMERICAN REVIEW OF RESPIRATORY DISEASE, Vol: 147, Pages: A502-A502, ISSN: 0003-0805
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- Citations: 5
WARD JK, FOX AJ, BARNES PJ, et al., 1993, 5-HYDROXYTRYPTAMINE INHIBITS EXCITATORY NONADRENERGIC NONCHOLINERGIC NEUROTRANSMISSION IN GUINEA-PIG AIRWAYS, AMERICAN REVIEW OF RESPIRATORY DISEASE, Vol: 147, Pages: A814-A814, ISSN: 0003-0805
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- Citations: 1
BELVISI MG, WARD JK, PATEL HJ, et al., 1993, MU-OPIOIDS INHIBIT ELECTRICALLY EVOKED ACETYLCHOLINE-RELEASE IN HUMAN AND GUINEA-PIG TRACHEA, AMERICAN REVIEW OF RESPIRATORY DISEASE, Vol: 147, Pages: A502-A502, ISSN: 0003-0805
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- Citations: 5
MIURA M, BELVISI MG, WARD JK, et al., 1993, ROLE OF CA2+-ACTIVATED K+ CHANNELS IN OPIOID-INDUCED PREJUNCTIONAL MODULATION OF AIRWAY SENSORY NERVES, AMERICAN REVIEW OF RESPIRATORY DISEASE, Vol: 147, Pages: A815-A815, ISSN: 0003-0805
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- Citations: 1
WARD JK, FOX AJ, MIURA M, et al., 1993, NITRIC-OXIDE MODULATES CHOLINERGIC NEUROTRANSMISSION IN HUMAN AIRWAYS, AMERICAN REVIEW OF RESPIRATORY DISEASE, Vol: 147, Pages: A515-A515, ISSN: 0003-0805
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- Citations: 1
BELVISI MG, WARD JK, TADJKARIMI S, et al., 1993, INHIBITORY NANC NERVES IN HUMAN AIRWAYS - DIFFERENCES IN DISEASE AND AFTER EXTRINSIC DENERVATION, AMERICAN REVIEW OF RESPIRATORY DISEASE, Vol: 147, Pages: A286-A286, ISSN: 0003-0805
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- Citations: 13
MIURA M, BELVISI MG, WARD JK, et al., 1993, BRONCHODILATING EFFECTS OF THE NOVEL POTASSIUM CHANNEL OPENER HOE-234 IN HUMAN AIRWAYS INVITRO, BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, Vol: 35, Pages: 318-320, ISSN: 0306-5251
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- Citations: 10
VERLEDEN GM, BELVISI MG, RABE KF, et al., 1993, BETA-2-ADRENOCEPTOR AGONISTS INHIBIT NANC NEURAL BRONCHOCONSTRICTOR RESPONSES INVITRO, JOURNAL OF APPLIED PHYSIOLOGY, Vol: 74, Pages: 1195-1199, ISSN: 8750-7587
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- Citations: 35
BELVISI MG, MIURA M, STRETTON D, et al., 1993, ENDOGENOUS VASOACTIVE-INTESTINAL-PEPTIDE AND NITRIC-OXIDE MODULATE CHOLINERGIC NEUROTRANSMISSION IN GUINEA-PIG TRACHEA, EUROPEAN JOURNAL OF PHARMACOLOGY, Vol: 231, Pages: 97-102, ISSN: 0014-2999
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- Citations: 64
Verleden GM, Belvisi MG, Rabe KF, et al., 1993, β<inf>2</inf>-Adrenoceptor agonists inhibit NANC neural bronchoconstrictor responses in vitro, Journal of Applied Physiology, Vol: 74, Pages: 1195-1199, ISSN: 8750-7587
Nonadrenergic noncholinergic (NANC) contractile responses in guinea pig bronchi are due to the release of tachykinins from airway sensory nerves. The purpose of this study was to determine whether β2-receptor agonists modulate NANC contractions in guinea pig bronchi in vitro. Bronchial rings were suspended in organ baths for isometric measurement of tension, and comparable contractions were induced by electrical field stimulation (EFS; 40 V, 0.5 ms, 8 Hz for 20 s) or by exogenous substance P (3 μM). Aformoterol and salbutamol produced concentration-dependent inhibition of the NANC contraction, with aformoterol being ninefold more potent than salbutamol; approximate 50% inhibitory concentrations for aformoterol and salbutamol were 1.03 nM (n = 6) and 9.3 nM (n = 6), respectively. Aformoterol also inhibited the contraction induced by exogenous substance P but to a far lesser extent than its inhibition of EFS-induced responses. The inhibitory effects of formoterol (10 nM) on responses to EFS at 8 Hz were significantly prevented by propranolol (1 μM) and ICI 1.18551 (a β2-antagonist, 0.1 μM) but not by atenolol (a β1-antagonist, 1 μM) or phentolamine (10 μM). These experiments demonstrate that β2-agonists may modulate the release of tachykinins from airway sensory nerves by prejunctional receptors.
BELVISI MG, STRETTON CD, MIURA M, et al., 1992, INHIBITORY NANC NERVES IN HUMAN TRACHEAL SMOOTH-MUSCLE - A QUEST FOR THE NEUROTRANSMITTER, JOURNAL OF APPLIED PHYSIOLOGY, Vol: 73, Pages: 2505-2510, ISSN: 8750-7587
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- Citations: 106
MIURA M, BELVISI MG, BARNES PJ, 1992, EFFECT OF BRADYKININ ON AIRWAY NEURAL RESPONSES INVITRO, JOURNAL OF APPLIED PHYSIOLOGY, Vol: 73, Pages: 1537-1541, ISSN: 8750-7587
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- Citations: 25
WARD JK, FOX AJ, MIURA M, et al., 1992, MODULATION OF CHOLINERGIC NEUROTRANSMISSION BY NITRIC-OXIDE IN HUMAN AIRWAY SMOOTH-MUSCLE, BRITISH JOURNAL OF PHARMACOLOGY, Vol: 107, Pages: P85-P85, ISSN: 0007-1188
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- Citations: 4
GIEMBYCZ MA, BELVISI MG, MIURA M, et al., 1992, SOLUBLE CYCLIC-NUCLEOTIDE PHOSPHODIESTERASE ISOENZYMES FROM HUMAN TRACHEAL SMOOTH-MUSCLE, BRITISH JOURNAL OF PHARMACOLOGY, Vol: 107, Pages: P52-P52, ISSN: 0007-1188
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- Citations: 8
BELVISI MG, MIURA M, PETERS MJ, et al., 1992, EFFECT OF ISOENZYME-SELECTIVE CYCLIC-NUCLEOTIDE PHOSPHODIESTERASE INHIBITORS ON HUMAN TRACHEAL SMOOTH-MUSCLE TONE, BRITISH JOURNAL OF PHARMACOLOGY, Vol: 107, Pages: P53-P53, ISSN: 0007-1188
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- Citations: 13
MIURA M, BELVISI MG, STRETTON CD, et al., 1992, ROLE OF K+ CHANNELS IN THE MODULATION OF CHOLINERGIC NEURAL RESPONSES IN GUINEA-PIG AND HUMAN AIRWAYS, JOURNAL OF PHYSIOLOGY-LONDON, Vol: 455, Pages: 1-15, ISSN: 0022-3751
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- Citations: 24
MIURA M, BELVISI MG, STRETTON CD, et al., 1992, ROLE OF POTASSIUM CHANNELS IN BRONCHODILATOR RESPONSES IN HUMAN AIRWAYS, AMERICAN REVIEW OF RESPIRATORY DISEASE, Vol: 146, Pages: 132-136, ISSN: 0003-0805
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- Citations: 119
BELVISI MG, MIURA M, STRETTON D, et al., 1992, CAPSAZEPINE AS A SELECTIVE ANTAGONIST OF CAPSAICIN-INDUCED ACTIVATION OF C-FIBERS IN GUINEA-PIG BRONCHI, EUROPEAN JOURNAL OF PHARMACOLOGY, Vol: 215, Pages: 341-344, ISSN: 0014-2999
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- Citations: 49
BELVISI MG, STRETTON CD, VERLEDEN GM, et al., 1992, INHIBITION OF CHOLINERGIC NEUROTRANSMISSION IN HUMAN AIRWAYS BY OPIOIDS, JOURNAL OF APPLIED PHYSIOLOGY, Vol: 72, Pages: 1096-1100, ISSN: 8750-7587
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- Citations: 52
STRETTON D, BELVISI MG, BARNES PJ, 1992, THE EFFECT OF SENSORY NERVE DEPLETION ON CHOLINERGIC NEUROTRANSMISSION IN GUINEA-PIG AIRWAYS, JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, Vol: 260, Pages: 1073-1080, ISSN: 0022-3565
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- Citations: 27
STRETTON D, MIURA M, BELVISI MG, et al., 1992, CALCIUM-ACTIVATED POTASSIUM CHANNELS MEDIATE PREJUNCTIONAL INHIBITION OF PERIPHERAL SENSORY NERVES, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Vol: 89, Pages: 1325-1329, ISSN: 0027-8424
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- Citations: 101
BELVISI MG, STRETTON CD, YACOUB M, et al., 1992, NITRIC-OXIDE IS THE ENDOGENOUS NEUROTRANSMITTER OF BRONCHODILATOR NERVES IN HUMANS, EUROPEAN JOURNAL OF PHARMACOLOGY, Vol: 210, Pages: 221-222, ISSN: 0014-2999
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- Citations: 344
BARNES PJ, BARANIUK JN, BELVISI MG, 1991, NEUROPEPTIDES IN THE RESPIRATORY-TRACT .2., AMERICAN REVIEW OF RESPIRATORY DISEASE, Vol: 144, Pages: 1391-1399, ISSN: 0003-0805
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- Citations: 195
Barnes PJ, Baraniuk JN, Belvisi MG, 1991, Neuropeptides in the respiratory tract. Part II., Am Rev Respir Dis, Vol: 144, Pages: 1391-1399, ISSN: 0003-0805
Hamid Q, Belvisi MG, Stretton D, et al., 1991, Localization of beta pre-protachykinin mRNA in nodose ganglion., Neuropeptides, Vol: 20, Pages: 145-150, ISSN: 0143-4179
The neurons which synthesize tachykinins in the capsaicin-sensitive afferent nerves of the respiratory tract are largely localized to the nodose ganglia. Using a radiolabelled antisense cRNA probe constructed from cDNA for the major precursor of substance P and neurokinin A (beta-preprotachykinin: beta-PPT), we have localized specific mRNA for this peptide in neurons of the nodose ganglion of rat using in situ hybridization. 26% of neurons gave a positive hybridization signal, which was in agreement with the same proportion of cell bodies showing substance P-like immunoreactivity. The specificity of the hybridization was confirmed by the absence of labelling using RNase pre-treatment and a sense probe having the same sequence as beta-PPT mRNA. This approach may now allow the investigation of factors which regulate synthesis of tachykinins at a gene transcriptional level.
BARNES PJ, BARANIUK JN, BELVISI MG, 1991, NEUROPEPTIDES IN THE RESPIRATORY-TRACT .1., AMERICAN REVIEW OF RESPIRATORY DISEASE, Vol: 144, Pages: 1187-1198, ISSN: 0003-0805
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- Citations: 380
HAMID Q, BELVISI MG, STRETTON D, et al., 1991, LOCALIZATION OF BETA-PRE-PROTACHYKININ MESSENGER-RNA IN NODOSE GANGLION, NEUROPEPTIDES, Vol: 20, Pages: 145-150, ISSN: 0143-4179
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- Citations: 5
Barnes PJ, Baraniuk JN, Belvisi MG, 1991, Neuropeptides in the respiratory tract. Part I., Am Rev Respir Dis, Vol: 144, Pages: 1187-1198, ISSN: 0003-0805
BELVISI MG, STRETTON CD, BARNES PJ, 1991, BOMBESIN-INDUCED BRONCHOCONSTRICTION IN THE GUINEA-PIG - MODE OF ACTION, JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, Vol: 258, Pages: 36-41, ISSN: 0022-3565
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- Citations: 22
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