Publications
411 results found
Baker KE, Raemdonck K, Dale N, et al., 2014, Determination Of The Key Effector Cells Involved In The Late Asthmatic Response, AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Vol: 189, ISSN: 1073-449X
Baker KE, Raemdonck K, Dekkak A, et al., 2014, Validation Of The Key Effector Cells Involved In Airway Hyper-Responsivity And Inflammation In A House Dust Mite Driven, Adjuvant Free Model Of Allergic Asthma, AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Vol: 189, ISSN: 1073-449X
Wortley MA, Birrell MA, Maher SA, et al., 2014, Profiling Of Xen-D0501, A Novel Trpv1 Antagonist, In Pre-Clinical Models Of Cough, AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Vol: 189, ISSN: 1073-449X
Raemdonck K, Birrell MA, Gozzard N, et al., 2014, Corticosteroid Insensitivity In A House Dust Mite And Freund's Complete Adjuvant Driven Mouse Model Of Allergic Asthma, AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Vol: 189, ISSN: 1073-449X
Bonvini SJ, Maher SA, Adcock JJ, et al., 2014, A Role For Atp And P2x3 In Activation Of Airway Sensory Nerves, AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Vol: 189, ISSN: 1073-449X
Dubuis E, Grace M, Wortley MA, et al., 2013, Harvesting, isolation, and functional assessment of primary vagal ganglia cells., Curr Protoc Pharmacol, Vol: 62, Pages: 12.15.1-12.15.27
Airway sensory nerves play an important defensive role in the lungs, being central in mediating protective responses like cough and bronchoconstriction. In some cases, these responses become excessive, hypersensitive, and deleterious. Understanding the normal function of airway nerves and phenotype changes associated with disease will help in developing new therapeutics for treating chronic obstructive pulmonary disease and chronic cough. Guinea pigs, and to a lesser extent ferrets, are commonly employed for studying the cough reflex because they have a cough response similar to humans. While rats and mice do not exhibit a cough response, they do possess sensory nerves that respond to the same range of tussive stimuli as guinea pigs and humans. Described in this unit are protocols for harvesting guinea pig, mouse, and rat sensory nerve cell bodies to assess molecular and functional changes associated with pulmonary disease, and to identify new targets for therapeutic intervention.
Grace MS, Dubuis E, Birrell MA, et al., 2013, Pre-clinical studies in cough research: Role of Transient Receptor Potential (TRP) channels, PULMONARY PHARMACOLOGY & THERAPEUTICS, Vol: 26, Pages: 498-507, ISSN: 1094-5539
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- Citations: 46
Morice A, Chung KF, Dicpinigaitis P, et al., 2013, Cough hypersentivity syndrome: Preliminary findings of the ERS taskforce, EUROPEAN RESPIRATORY JOURNAL, Vol: 42, ISSN: 0903-1936
Bonvini SJ, Adcock JJ, Grace MS, et al., 2013, Activation of TRPV4 causes bronchoconstriction: A possible role in respiratory disease?, EUROPEAN RESPIRATORY JOURNAL, Vol: 42, ISSN: 0903-1936
Maher S, Birrell M, Adcock J, et al., 2013, Investigating the role of prostaglandin D<sub>2</sub> in airway sensory nerve firing: Relevance to disease, EUROPEAN RESPIRATORY JOURNAL, Vol: 42, ISSN: 0903-1936
Shenker NS, Polidoro S, van Veldhoven K, et al., 2013, Epigenome-wide association study in the European Prospective Investigation into Cancer and Nutrition (EPIC-Turin) identifies novel genetic loci associated with smoking, HUMAN MOLECULAR GENETICS, Vol: 22, Pages: 843-851, ISSN: 0964-6906
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- Citations: 304
Rastrick JMD, Stevenson CS, Eltom S, et al., 2013, Cigarette smoke induced airway inflammation is independent of NF-kappa B signalling, PLOS One, Vol: 8, ISSN: 1932-6203
Dubuis E, Grace M, Wortley MA, et al., 2013, Harvesting, isolation, and functional assessment of primary vagal ganglia cells, Current Protocols in Pharmacology, Vol: 1, ISSN: 1934-8282
Airway sensory nerves play an important defensive role in the lungs, being central in mediating protective responses like cough and bronchoconstriction. In some cases, these responses become excessive, hypersensitive, and deleterious. Understanding the normal function of airway nerves and phenotype changes associated with disease will help in developing new therapeutics for treating chronic obstructive pulmonary disease and chronic cough. Guinea pigs, and to a lesser extent ferrets, are commonly employed for studying the cough reflex because they have a cough response similar to humans. While rats and mice do not exhibit a cough response, they do possess sensory nerves that respond to the same range of tussive stimuli as guinea pigs and humans. Described in this unit are protocols for harvesting guinea pig, mouse, and rat sensory nerve cell bodies to assess molecular and functional changes associated with pulmonary disease, and to identify new targets for therapeutic intervention. © 2013 by John Wiley & Sons, Inc.
Birrell MA, Maher SA, Buckley J, et al., 2013, Selectivity profiling of the novel EP2 receptor antagonist, PF-04418948, in functional bioassay systems: atypical affinity at the guinea pig EP2 receptor, BRITISH JOURNAL OF PHARMACOLOGY, Vol: 168, Pages: 129-138, ISSN: 0007-1188
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- Citations: 24
Raemdonck K, Dale N, Murray-Lyon IM, et al., 2013, The Effect Of Cathinone In Allergic Asthma, AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Vol: 187, ISSN: 1073-449X
Bonvini SJ, Birrell MA, Maher SA, et al., 2013, Modulation Of Sensory Nerve Responses And Cough By Tiotropium Bromide, AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Vol: 187, ISSN: 1073-449X
Maher SA, Birrell MA, Wortley MA, et al., 2013, The Role Of Prostaglandin D2 In The Activation Of Sensory Nerves And Cough, AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Vol: 187, ISSN: 1073-449X
Wortley MA, Birrell MA, Bonvini SJ, et al., 2013, An Investigation Into The Anti-Tussive Properties Of β1-, β2-, And β3-Adrenoceptor Agonists, AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Vol: 187, ISSN: 1073-449X
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- Citations: 1
Eltom S, Dale N, Raemdonck K, et al., 2013, Role Of Extracellular Vesicles In The Exacerbations Of Asthma And COPD, AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Vol: 187, ISSN: 1073-449X
Rastrick JM, Stevenson CS, Eltom S, et al., 2013, Correction: Cigarette Smoke Induced Airway Inflammation Is Independent of NF-κB Signalling., PLoS One, Vol: 8
[This corrects the article on p. e54128 in vol. 8.].
Jones VC, Maher SA, Birrell MA, et al., 2013, The Role Of Prostanoids In Airway Microvascular Leak, AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Vol: 187, ISSN: 1073-449X
Dale N, Raemdonck K, Belvisi MG, et al., 2013, Topical Hdm Sensitisation: Does It Lead To A Model Of Allergic Asthma?, AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Vol: 187, ISSN: 1073-449X
Dale N, Raemdonck K, Belvisi MG, et al., 2013, Is Alumtm Required To Generate An Allergic Asthmatic Phenotype In The Ovalbumin Model?, AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Vol: 187, ISSN: 1073-449X
Bartlett NW, Slater L, Glanville N, et al., 2012, Defining critical roles for NF-?B p65 and type I interferon in innate immunity to rhinovirus, EMBO MOLECULAR MEDICINE, Vol: 4, Pages: 1244-1260, ISSN: 1757-4676
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- Citations: 67
Grace M, Birrell MA, Dubuis E, et al., 2012, Transient receptor potential channels mediate the tussive response to prostaglandin E<sub>2</sub> and bradykinin, THORAX, Vol: 67, Pages: 891-900, ISSN: 0040-6376
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- Citations: 111
Clark AR, Belvisi MG, 2012, Maps and legends: The quest for dissociated ligands of the glucocorticoid receptor, PHARMACOLOGY & THERAPEUTICS, Vol: 134, Pages: 54-67, ISSN: 0163-7258
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- Citations: 168
Grace MS, Dubuis E, Birrell MA, et al., 2012, TRP Channel Antagonists as Potential Antitussives, LUNG, Vol: 190, Pages: 11-15, ISSN: 0341-2040
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- Citations: 14
Raemdonck K, de Alba J, Birrell MA, et al., 2012, A role for sensory nerves in the late asthmatic response, THORAX, Vol: 67, Pages: 19-25, ISSN: 0040-6376
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- Citations: 89
Khalid S, Dockry R, Holt K, et al., 2011, COUGH RESPONSES TO TUSSIVE AGENTS IN HEALTH AND DISEASE, Winter Meeting of the British-Thoracic-Society, Publisher: B M J PUBLISHING GROUP, Pages: A64-A64, ISSN: 0040-6376
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- Citations: 2
Buckley J, Birrell MA, Maher SA, et al., 2011, EP<sub>4</sub> receptor as a new target for bronchodilator therapy, THORAX, Vol: 66, Pages: 1029-1035, ISSN: 0040-6376
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- Citations: 85
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