Publications
411 results found
Belvisi MG, Hele DJ, 2009, Cough sensors. III. Opioid and cannabinoid receptors on vagal sensory nerves., Handb Exp Pharmacol, Pages: 63-76, ISSN: 0171-2004
Cough is a persistent symptom of many inflammatory airways' diseases. Cough is mediated by receptors sited on sensory nerves and then through vagal afferent pathways, which terminate in the brainstem respiratory centre. Cough is often described as an unmet clinical need. Opioids are the only prescription-based antitussives currently available in the UK. They possess limited efficacy and exhibit serious unwanted side effects, such as physical dependence, sedation, respiratory depression and gastrointestinal symptoms. There are three classical opioid receptors: the mu, kappa and delta receptors. Peripheral opioid receptors are sited on sensory nerves innervating the airways. A greater understanding of the role of the peripheral and centrally sited opioid receptors is necessary to allow the development of targeted treatments for cough. Because of the limited efficacy and the side-effect profile of the opioids, potential new treatments are sought to alleviate cough. One class of compounds that is currently under examination is the cannabinoids. Like the opioids, cannabinoids have peripheral and centrally sited receptors and also suffer from the blight of unwanted centrally mediated side effects such as sedation, cognitive dysfunction, tachycardia and psychotropic effects. Two cannabinoid receptors have been identified, the CB(1) and CB(2) receptors, and their distribution varies throughout the peripheral and central nervous system. Encouragingly, early studies with these compounds suggest that it may be possible to separate their antitussive activity from their centrally mediated side effects, with CB(2) agonists showing potential as putative new treatments for cough. In this chapter, we describe the opioid and cannabinoid receptors, their distribution and the effects they mediate. Moreover, we highlight their potential advantages and disadvantages in the treatment of cough.
Clarke DL, Jindarat S, Proud D, et al., 2009, TNFα and IFNγ Phosphorylate RNA Polymerase II To Synergistically Enhance CXCL-10 Release from Human Airway Smooth Muscle Cells., AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Vol: 179, ISSN: 1073-449X
Grace MS, Birrell MA, Maher SA, et al., 2009, Pharmacological Characterisation of the Adenosine Receptor Involved in Activation of Rat and Guinea-Pig Vagal Sensory Nerves., AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Vol: 179, ISSN: 1073-449X
Maher SA, Birrell MA, Belvisi MG, 2009, Prostaglandin E2 Mediates Cough Via the EP3 Receptor., AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Vol: 179, ISSN: 1073-449X
Clarke DL, Hardaker EL, Catley MC, et al., 2009, Inhibition of JAK/STAT Signalling: A Novel Therapy for Steroid Resistant Asthma?, AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Vol: 179, ISSN: 1073-449X
Belvisi MG, Patel HJ, Freund-Michel V, et al., 2008, Inhibitory activity of the novel CB<sub>2</sub> receptor agonist, GW833972A, on guinea-pig and human sensory nerve function in the airways, BRITISH JOURNAL OF PHARMACOLOGY, Vol: 155, Pages: 547-557, ISSN: 0007-1188
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- Citations: 43
Birrell MA, De Alba J, Catley MC, et al., 2008, Liver X receptor agonists increase airway reactivity in a model of asthma via increasing airway smooth muscle growth, JOURNAL OF IMMUNOLOGY, Vol: 181, Pages: 4265-4271, ISSN: 0022-1767
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- Citations: 23
Freund-Michel VC, Birrell MA, Patel HJ, et al., 2008, Modulation of cholinergic contractions of airway smooth muscle by cathinone: potential beneficial effects in airway diseases, EUROPEAN RESPIRATORY JOURNAL, Vol: 32, Pages: 579-584, ISSN: 0903-1936
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- Citations: 10
Catley MC, Birrell MA, Hardaker EL, et al., 2008, Estrogen receptor β:: Expression profile and possible anti-inflammatory role in disease, JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, Vol: 326, Pages: 83-88, ISSN: 0022-3565
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- Citations: 26
Belvisi MG, Hele DJ, 2008, Peroxisome proliferator-activated receptors as novel targets in lung disease, CHEST, Vol: 134, Pages: 152-157, ISSN: 0012-3692
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- Citations: 60
Belvisi MG, 2008, Preclinical assessment of novel therapeutics on the cough reflex: Cannabinoid agonists as potential antitussives, 1st American Cough Conference, Pages: S66-S69
Cough, a reflex defense mechanism, is a common symptom of many airway inflammatory diseases. At present there are no satisfactory treatments for cough that have an acceptable side effect profile. Recent data have described the inhibitory effect of selective cannabinoid CB, receptor agonists on sensory nerve activity in vitro and the cough reflex in a guinea pig model. CB2 receptor expression is limited in the central nervous system (CNS) and hence the development of selective agonists may provide a new therapeutic strategy for treatment of cough devoid of the CNS-mediated side effects that are normally associated with nonselective cannabinoid agonists.
Belvisi MG, 2008, Preclinical assessment of novel therapeutics on the cough reflex: Cannabinoid agonists as potential antitussives, LUNG, Vol: 186, Pages: S66-S69, ISSN: 0341-2040
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- Citations: 7
Mark A Birrell, Sissie Wong, Matthew C Catley, et al., 2008, Impact of tobacco-smoke on key signalling pathways in the innate immune response in lung macrophages, Journal of Cellular Physiology
Birrell MA, Catley MC, Hardaker E, et al., 2007, Novel role for the liver X nuclear receptor in the suppression of lung inflammatory responses, JOURNAL OF BIOLOGICAL CHEMISTRY, Vol: 282, Pages: 31882-31890
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- Citations: 49
Moschos SA, Williams AE, Perry MM, et al., 2007, Expression profiling in vivo demonstrates rapid changes in lung microRNA levels following lipopolysaccharide-induced inflammation but not in the anti-inflammatory action of glucocorticoids, BMC GENOMICS, Vol: 8, ISSN: 1471-2164
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- Citations: 221
Morice AH, Fontana GA, Belvisi MG, et al., 2007, ERS guidelines on the assessment of cough, EUROPEAN RESPIRATORY JOURNAL, Vol: 29, Pages: 1256-1276, ISSN: 0903-1936
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- Citations: 467
Birrell MA, McCluskie K, Hardaker E, et al., 2006, Utility of exhaled nitric oxide as a noninvasive biomarker of lung inflammation in a disease model, EUROPEAN RESPIRATORY JOURNAL, Vol: 28, Pages: 1236-1244, ISSN: 0903-1936
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- Citations: 30
Birrell MA, Wong S, Dekkak A, et al., 2006, Role of matrix metalloproteinases in the inflammatory response in human airway cell-based assays and in rodent models of airway disease, JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, Vol: 318, Pages: 741-750, ISSN: 0022-3565
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- Citations: 15
Birrell M, Wong S, Belvisi M, 2006, Role of matrix metalloproteinases in the inflammatory response in human airway cell based assays and in a rat model of airways inflammation., ACTA PHARMACOLOGICA SINICA, Vol: 27, Pages: 262-262, ISSN: 1671-4083
Belvisi MG, Birrell M, Wong S, et al., 2006, Pharmacological approaches for the treatment of COPD, ACTA PHARMACOLOGICA SINICA, Vol: 27, Pages: 37-38, ISSN: 1671-4083
Clarke D, Crispino N, Birrell M, et al., 2006, Elucidation of the receptor(s) involved in the modulation of sensory nerve activty evoked by PGE2, Publisher: BLACKWELL PUBLISHING, Pages: 376-376, ISSN: 1671-4083
Birrell MA, Wong S, Hardaker EL, et al., 2006, IκB kinase-2independent and -dependent inflammation in airway disease models:: Relevance of IKK-2 inhibition to the clinic, MOLECULAR PHARMACOLOGY, Vol: 69, Pages: 1791-1800, ISSN: 0026-895X
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- Citations: 50
Belvisi MG, Hele DJ, Birrell MA, 2006, Peroxisome proliferator-activated receptor gamma agonists as therapy for chronic airway inflammation, EUROPEAN JOURNAL OF PHARMACOLOGY, Vol: 533, Pages: 101-109, ISSN: 0014-2999
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- Citations: 113
Birrell MA, Wong S, McCluskie K, et al., 2006, Second-generation inhibitors demonstrate the involvement of p38 mitogen-activated protein kinase in post-transcriptional modulation of inflammatory mediator production in human and rodent airways, JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, Vol: 316, Pages: 1318-1327, ISSN: 0022-3565
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- Citations: 20
Birrell MA, Hardaker E, Wong S, et al., 2005, Iκ-B kinase-2 inhibitor blocks inflammation in human airway smooth muscle and a rat model of asthma, AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Vol: 172, Pages: 962-971, ISSN: 1073-449X
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- Citations: 112
Belvisi MG, Bundschuh DS, Stoeck M, et al., 2005, Preclinical profile of ciclesonide, a novel corticosteroid for the treatment of asthma, JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, Vol: 314, Pages: 568-574, ISSN: 0022-3565
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- Citations: 37
Birrell MA, Wong S, Hele DJ, et al., 2005, Steroid-resistant inflammation in a rat model of chronic obstructive pulmonary disease is associated with a lack of nuclear factor-κB pathway activation, AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Vol: 172, Pages: 74-84, ISSN: 1073-449X
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- Citations: 43
Belvisi MG, Broadley K, 2005, Don't forget the nose and pulmonary circulation! Editorial overview, CURRENT OPINION IN PHARMACOLOGY, Vol: 5, Pages: 211-213, ISSN: 1471-4892
Clarke DL, Belvisi MG, Smith SJ, et al., 2005, Prostanoid receptor expression by human airway smooth muscle cells and regulation of the secretion of granulocyte colony-stimulating factor, AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY, Vol: 288, Pages: L238-L250, ISSN: 1040-0605
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- Citations: 38
Clarke DL, Belvisi MG, Hardaker E, et al., 2005, E-ring 8-isoprostanes are agonists at EP<sub>2</sub>- and EP<sub>4</sub>-prostanoid receptors on human airway smooth muscle cells and regulate the release of colony-stimulating factors by activating cAMP-dependent protein kinase, MOLECULAR PHARMACOLOGY, Vol: 67, Pages: 383-393, ISSN: 0026-895X
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- Citations: 22
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