Imperial College London
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DrMartynBiddiscombe

Faculty of Medicine, National Heart & Lung Institute

Medical Physicist
 
 
 
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Contact

 

m.biddiscombe Website

 
 
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Location

 

342Norfolk PlaceSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@inproceedings{Matthews:2011:10.1089/jamp.2011.00A1,
author = {Matthews, JC and Wright, MD and Biddiscombe, MF and Underwood, SR and Usmani, OS and Henshaw, DL},
doi = {10.1089/jamp.2011.00A1},
title = {HUMAN VOLUNTEER INHALATIONAND LUNG DEPOSITIONOF CHARGED AEROSOLS - CHARACTERISATIONOF CHARGE STATE USING AN ELPI},
url = {http://dx.doi.org/10.1089/jamp.2011.00A1},
year = {2011}
}
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RIS format (EndNote, RefMan)

TY  - CPAPER
AB  - Effects of particle electric charge state are important to theefficiency of drug delivery to the lung and possibly to exposureto pollutants charged by corona ions near high voltage powerlines. We plan to test whether 100 and 200nm particles withexcess charge have a higher probability of lung deposition thancharge-neutralised particles, when inhaled by healthy volunteers.The study requires characterisation of both the charge stateand size of inhaled particles.The extent of aerosol charging can be examined using anElectrical Low Pressure Impactor (ELPI), a cascade impactorwith an internal corona charger. The current on each impactorstage is measured and the size distribution obtained in conjunctionwith the charging probability. To test the proposedmethodology, the ELPI was used to measure ambient aircharged by a negative air ioniser. The ELPI internal charger wasswitched on and off at 30 s intervals to allow alternate, on-linemeasurement of both size and charge distributions.The modal average concentration and inter-quartile range of120 and 200nm particles, with the internal corona charger on,was 2000 194 and 1217 132 cm 3 respectively. The averageambient charge per particle (with internal charger off) was estimatedat 0.6 and 1.1 e, respectively. In conclusion, the ELPI canbe used effectively, through regular switching of the coronacharger, to estimate the average charge of aerosols.
AU  - Matthews,JC
AU  - Wright,MD
AU  - Biddiscombe,MF
AU  - Underwood,SR
AU  - Usmani,OS
AU  - Henshaw,DL
DO  - 10.1089/jamp.2011.00A1
PY  - 2011///
TI  - HUMAN VOLUNTEER INHALATIONAND LUNG DEPOSITIONOF CHARGED AEROSOLS - CHARACTERISATIONOF CHARGE STATE USING AN ELPI
UR  - http://dx.doi.org/10.1089/jamp.2011.00A1
UR  - http://www.liebertonline.com/doi/abs/10.1089/jamp.2011.00A1
ER  -
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