Publications
120 results found
Birrell MA, Catley MC, Hardaker E, et al., 2007, Novel role for the liver X nuclear receptor in the suppression of lung inflammatory responses, JOURNAL OF BIOLOGICAL CHEMISTRY, Vol: 282, Pages: 31882-31890
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- Citations: 49
Moschos SA, Williams AE, Perry MM, et al., 2007, Expression profiling in vivo demonstrates rapid changes in lung microRNA levels following lipopolysaccharide-induced inflammation but not in the anti-inflammatory action of glucocorticoids, BMC GENOMICS, Vol: 8, ISSN: 1471-2164
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- Citations: 221
Birrell MA, McCluskie K, Hardaker E, et al., 2006, Utility of exhaled nitric oxide as a noninvasive biomarker of lung inflammation in a disease model, EUROPEAN RESPIRATORY JOURNAL, Vol: 28, Pages: 1236-1244, ISSN: 0903-1936
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- Citations: 30
Birrell MA, Wong S, Dekkak A, et al., 2006, Role of matrix metalloproteinases in the inflammatory response in human airway cell-based assays and in rodent models of airway disease, JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, Vol: 318, Pages: 741-750, ISSN: 0022-3565
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- Citations: 15
Birrell MA, Wong S, Hardaker EL, et al., 2006, IκB kinase-2independent and -dependent inflammation in airway disease models:: Relevance of IKK-2 inhibition to the clinic, MOLECULAR PHARMACOLOGY, Vol: 69, Pages: 1791-1800, ISSN: 0026-895X
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- Citations: 50
Belvisi MG, Hele DJ, Birrell MA, 2006, Peroxisome proliferator-activated receptor gamma agonists as therapy for chronic airway inflammation, EUROPEAN JOURNAL OF PHARMACOLOGY, Vol: 533, Pages: 101-109, ISSN: 0014-2999
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- Citations: 113
Birrell MA, Wong S, McCluskie K, et al., 2006, Second-generation inhibitors demonstrate the involvement of p38 mitogen-activated protein kinase in post-transcriptional modulation of inflammatory mediator production in human and rodent airways, JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, Vol: 316, Pages: 1318-1327, ISSN: 0022-3565
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- Citations: 20
Birrell MA, Hardaker E, Wong S, et al., 2005, Iκ-B kinase-2 inhibitor blocks inflammation in human airway smooth muscle and a rat model of asthma, AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Vol: 172, Pages: 962-971, ISSN: 1073-449X
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- Citations: 112
Belvisi MG, Bundschuh DS, Stoeck M, et al., 2005, Preclinical profile of ciclesonide, a novel corticosteroid for the treatment of asthma, JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, Vol: 314, Pages: 568-574, ISSN: 0022-3565
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- Citations: 37
Birrell MA, Wong S, Hele DJ, et al., 2005, Steroid-resistant inflammation in a rat model of chronic obstructive pulmonary disease is associated with a lack of nuclear factor-κB pathway activation, AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Vol: 172, Pages: 74-84, ISSN: 1073-449X
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- Citations: 43
Birrell MA, McCluskie K, Wong SS, et al., 2005, Resveratrol, an extract of red wine, inhibits lipopolysaccharide induced airway neutrophilia and inflammatory mediators through an NF-κB-independent mechanism, FASEB JOURNAL, Vol: 19, Pages: 840-+, ISSN: 0892-6638
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- Citations: 140
Usmani OS, Belvisi MG, Patel HJ, et al., 2004, Theobromine inhibits sensory nerve activation and cough, FASEB JOURNAL, Vol: 18, Pages: 231-+, ISSN: 0892-6638
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- Citations: 80
McCluskie K, Birrell MA, Wong S, et al., 2004, Nitric oxide as a noninvasive biomarker of lipopolysaccharide-induced airway inflammation: Possible role in lung neutrophilia, JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, Vol: 311, Pages: 625-633, ISSN: 0022-3565
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- Citations: 30
Belvisi MG, Hele DJ, Birrell MA, 2004, New anti-inflammatory therapies and targets for asthma and chronic obstructive pulmonary disease, EXPERT OPINION ON THERAPEUTIC TARGETS, Vol: 8, Pages: 265-285, ISSN: 1472-8222
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- Citations: 29
Birrell MA, Patel HJ, McCluskie K, et al., 2004, PPAR-γ agonists as therapy for diseases involving airway neutrophilia, EUROPEAN RESPIRATORY JOURNAL, Vol: 24, Pages: 18-23, ISSN: 0903-1936
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- Citations: 75
Birrell MA, McCluskie K, Belvisi MG, 2004, Characterization of a pre-clinical model of airway inflammation: exhaled nitric oxide (exNO) as a non-invasive biomarker, FUNDAMENTAL & CLINICAL PHARMACOLOGY, Vol: 18, Pages: 105-105, ISSN: 0767-3981
Belvisi MG, Hele DJ, Birrell MA, 2004, New advances and potential therapies for the treatment of asthma, BIODRUGS, Vol: 18, Pages: 211-223, ISSN: 1173-8804
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- Citations: 19
Patel HJ, Birrell MA, Crispino N, et al., 2003, Inhibition of guinea-pig and human sensory nerve activity and the cough reflex in guinea-pigs by cannabinoid (CB2) receptor activation, BRITISH JOURNAL OF PHARMACOLOGY, Vol: 140, Pages: 261-268, ISSN: 0007-1188
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- Citations: 70
Birrell MA, Battram CH, Woodman P, et al., 2003, Dissociation by steroids of eosinophilic inflammation from airway hyperresponsiveness in murine airways, Respiratory Research, Vol: 4, ISSN: 1465-9921
BackgroundThe link between eosinophils and the development of airway hyperresponsiveness (AHR) in asthma is still controversial. This question was assessed in a murine model of asthma in which we performed a dose ranging study to establish whether the dose of steroid needed to inhibit the eosinophil infiltration correlated with that needed to block AHR.MethodsThe sensitised BALB/c mice were dosed with vehicle or dexamethasone (0.01–3 mg/kg) 2 hours before and 6 hours after each challenge (once daily for 6 days) and 2 hours before AHR determination by whole-body plethysmography. At 30 minutes after the AHR to aerosolised methacholine the mice were lavaged and differential white cell counts were determined. Challenging with antigen caused a significant increase in eosinophils in the bronchoalveolar lavage (BAL) fluid and lung tissue, and increased AHR.ResultsDexamethasone reduced BAL and lung tissue eosinophilia (ED50 values of 0.06 and 0.08 mg/kg, respectively), whereas a higher dose was needed to block AHR (ED50 of 0.32 mg/kg at 3 mg/ml methacholine. Dissociation was observed between the dose of steroid needed to affect AHR in comparison with eosinophilia and suggests that AHR is not a direct consequence of eosinophilia.ConclusionThis novel pharmacological approach has revealed a clear dissociation between eosinophilia and AHR by using steroids that are the mainstay of asthma therapy. These data suggest that eosinophilia is not associated with AHR and questions the rationale that many pharmaceutical companies are adopting in developing low-molecular-mass compounds that target eosinophil activation/recruitment for the treatment of asthma.
Birrell MA, McCluskie K, Haddad EB, et al., 2003, Pharmacological assessment of the nitric-oxide synthase isoform involved in eosinophilic inflammation in a rat model of Sephadex-induced airway inflammation, JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, Vol: 304, Pages: 1285-1291, ISSN: 0022-3565
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- Citations: 16
Belvisi MG, Hele DJ, 2003, Soft steroids: a new approach to the treatment of inflammatory airways diseases, PULMONARY PHARMACOLOGY & THERAPEUTICS, Vol: 16, Pages: 321-325, ISSN: 1094-5539
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- Citations: 58
Underwood SL, Haddad EB, Birrell MA, et al., 2002, Functional characterization and biomarker identification in the Brown Norway model of allergic airway inflammation, BRITISH JOURNAL OF PHARMACOLOGY, Vol: 137, Pages: 263-275, ISSN: 0007-1188
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- Citations: 29
Haddad EB, McCluskie K, Birrell MA, et al., 2002, Differential effects of ebselen on neutrophil recruitment, chemokine, and inflammatory mediator expression in a rat model of lipopolysaccharide-induced pulmonary inflammation, JOURNAL OF IMMUNOLOGY, Vol: 169, Pages: 974-982, ISSN: 0022-1767
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- Citations: 62
Birrell MA, Crispino N, Hele DJ, et al., 2002, Effect of dopamine receptor agonists on sensory nerve activity: possible therapeutic targets for the treatment of asthma and COPD, BRITISH JOURNAL OF PHARMACOLOGY, Vol: 136, Pages: 620-628, ISSN: 0007-1188
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- Citations: 33
Haddad EB, Underwood SL, Dabrowski D, et al., 2002, Critical role for T cells in sephadex-induced airway inflammation: Pharmacological and immunological characterization and molecular biomarker identification, JOURNAL OF IMMUNOLOGY, Vol: 168, Pages: 3004-3016, ISSN: 0022-1767
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- Citations: 23
Spicuzza L, Belvisi MG, Birrell MA, et al., 2001, Evidence that the anti-spasmogenic effect of the β-adrenoceptor agonist, isoprenaline, on guinea-pig trachealis is not mediated by cyclic AMP-dependent protein kinase, BRITISH JOURNAL OF PHARMACOLOGY, Vol: 133, Pages: 1201-1212, ISSN: 0007-1188
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- Citations: 38
Hele DJ, Birrell MA, Webber SE, et al., 2001, Mediator involvement in antigen-induced bronchospasm and microvascular leakage in the airways of ovalbumin sensitized Brown Norway rats, BRITISH JOURNAL OF PHARMACOLOGY, Vol: 132, Pages: 481-488, ISSN: 0007-1188
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- Citations: 33
Hele DJ, Birrell MA, Webber SE, et al., 2000, Effect of endothelin antagonists, including the novel ET<sub>A</sub> receptor antagonist LBL 031, on endothelin-1 and lipopolysaccharide-induced microvascular leakage in rat airways, BRITISH JOURNAL OF PHARMACOLOGY, Vol: 131, Pages: 1129-1134, ISSN: 0007-1188
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- Citations: 10
Escott KJ, Belvisi MG, Birrell MA, et al., 2000, Effect of the p38 kinase inhibitor, SE 203580, on allergic airway inflammation in the rat, BRITISH JOURNAL OF PHARMACOLOGY, Vol: 131, Pages: 173-176, ISSN: 0007-1188
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- Citations: 48
Spicuzza L, Haddad EB, Birrell M, et al., 2000, Characterization of the effects of cannabinoids on guinea-pig tracheal smooth muscle tone: role in the modulation of acetylcholine release from parasympathetic nerves, BRITISH JOURNAL OF PHARMACOLOGY, Vol: 130, Pages: 1720-1726, ISSN: 0007-1188
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- Citations: 20
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