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@article{Lilburn:2015:10.1098/rsif.2015.0192,
author = {Lilburn, DML and Lesbats, C and Six, JS and Dubuis, E and Yew-Booth, L and Shaw, DE and Belvisi, MG and Birrell, MA and Pavlovskaya, GE and Meersmann, T},
doi = {10.1098/rsif.2015.0192},
journal = {Journal of the Royal Society Interface},
title = {Hyperpolarized Kr-83 magnetic resonance imaging of alveolar degradation in a rat model of emphysema},
url = {http://dx.doi.org/10.1098/rsif.2015.0192},
volume = {12},
year = {2015}
}

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TY  - JOUR
AB  - Hyperpolarized ³Kr surface quadrupolar relaxation (SQUARE) generates MRI contrast that was previously shown to correlate with surface-to-volume ratios in porous model surface systems. The underlying physics of SQUARE contrast is conceptually different from any other current MRI methodology as the method uses the nuclear electric properties of the spin I = 9/2 isotope 83Kr. To explore the usage of this non-radioactive isotope for pulmonary pathophysiology, MRI SQUARE contrast was acquired in excised rat lungs obtained from an elastase-induced model of emphysema. A significant ³Kr T relaxation time increase in the SQUARE contrast was found in the elastase-treated lungs compared with the baseline data from control lungs. The SQUARE contrast suggests a reduction in pulmonary surface-to-volume ratio in the emphysema model that was validated by histology. The finding supports usage of 83Kr SQUARE as a new biomarker for surface-to-volume ratio changes in emphysema.
AU  - Lilburn,DML
AU  - Lesbats,C
AU  - Six,JS
AU  - Dubuis,E
AU  - Yew-Booth,L
AU  - Shaw,DE
AU  - Belvisi,MG
AU  - Birrell,MA
AU  - Pavlovskaya,GE
AU  - Meersmann,T
DO  - 10.1098/rsif.2015.0192
PY  - 2015///
SN  - 1742-5689
TI  - Hyperpolarized Kr-83 magnetic resonance imaging of alveolar degradation in a rat model of emphysema
T2  - Journal of the Royal Society Interface
UR  - http://dx.doi.org/10.1098/rsif.2015.0192
UR  - http://hdl.handle.net/10044/1/28203
VL  - 12
ER  -

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