Imperial College London
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DrMarkBirrell

Faculty of Medicine, National Heart & Lung Institute

Senior Research Fellow
 
 
 
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Contact

 

+44 (0)20 7594 8578m.birrell

 
 
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Location

 

103Sir Alexander Fleming BuildingSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Baker:2016:10.1186/s12931-016-0384-x,
author = {Baker, K and Raemdonck, K and Dekkak, B and Snelgrove, RJ and Ford, J and Shala, F and Belvisi, MG and Birrell, MA},
doi = {10.1186/s12931-016-0384-x},
journal = {Respiratory Research},
title = {Role of the ion channel, transient receptor potential cation channel subfamily V member 1 (TRPV1), in allergic asthma},
url = {http://dx.doi.org/10.1186/s12931-016-0384-x},
volume = {17},
year = {2016}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - BACKGROUND: Asthma prevalence has increased world-wide especially in children; thus there is a need to develop new therapies that are safe and effective especially for patients with severe/refractory asthma. CD4(+) T cells are thought to play a central role in disease pathogenesis and associated symptoms. Recently, TRPV1 has been demonstrated to regulate the activation and inflammatory properties of CD4(+) cells. The aim of these experiments was to demonstrate the importance of CD4(+) T cells and the role of TRPV1 in an asthma model using a clinically ready TRPV1 inhibitor (XEN-D0501) and genetically modified (GM) animals. METHODS: Mice (wild type, CD4 (-/-) or TRPV1 (-/-)) and rats were sensitised with antigen (HDM or OVA) and subsequently topically challenged with the same antigen. Key features associated with an allergic asthma type phenotype were measured: lung function (airway hyperreactivity [AHR] and late asthmatic response [LAR]), allergic status (IgE levels) and airway inflammation. RESULTS: CD4(+) T cells play a central role in both disease model systems with all the asthma-like features attenuated. Targeting TRPV1 using either GM mice or a pharmacological inhibitor tended to decrease IgE levels, airway inflammation and lung function changes. CONCLUSION: Our data suggests the involvement of TRPV1 in allergic asthma and thus we feel this target merits further investigation.
AU  - Baker,K
AU  - Raemdonck,K
AU  - Dekkak,B
AU  - Snelgrove,RJ
AU  - Ford,J
AU  - Shala,F
AU  - Belvisi,MG
AU  - Birrell,MA
DO  - 10.1186/s12931-016-0384-x
PY  - 2016///
SN  - 1465-993X
TI  - Role of the ion channel, transient receptor potential cation channel subfamily V member 1 (TRPV1), in allergic asthma
T2  - Respiratory Research
UR  - http://dx.doi.org/10.1186/s12931-016-0384-x
UR  - http://hdl.handle.net/10044/1/33574
VL  - 17
ER  -
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