Imperial College London
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DrMarkBirrell

Faculty of Medicine, National Heart & Lung Institute

Senior Research Fellow
 
 
 
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Contact

 

+44 (0)20 7594 8578m.birrell

 
 
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Location

 

103Sir Alexander Fleming BuildingSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Mesnil:2016:10.1172/JCI85664,
author = {Mesnil, C and Raulier, S and Paulissen, G and Xiao, X and Birrell, MA and Pirottin, D and Janss, T and Starkl, P and Ramery, E and Henket, M and Schleich, FN and Radermecker, M and Thielemans, K and Gillet, L and Thiry, M and Belvisi, MG and Louis, R and Desmet, C and Marichal, T and Bureau, F},
doi = {10.1172/JCI85664},
journal = {Journal of Clinical Investigation},
pages = {3279--3295},
title = {Lung-resident eosinophils represent a distinct regulatory eosinophil subset},
url = {http://dx.doi.org/10.1172/JCI85664},
volume = {126},
year = {2016}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Increases in eosinophil numbers are associated with infection and allergic diseases, including asthma, but there is also evidence that eosinophils contribute to homeostatic immune processes. In mice, the normal lung contains resident eosinophils (rEos), but their function has not been characterized. Here, we have reported that steady-state pulmonary rEos are IL-5-independent parenchymal Siglec-FintCD62L+CD101lo cells with a ring-shaped nucleus. During house dust mite-induced airway allergy, rEos features remained unchanged, and rEos were accompanied by recruited inflammatory eosinophils (iEos), which were defined as IL-5-dependent peribronchial Siglec-FhiCD62L-CD101hi cells with a segmented nucleus. Gene expression analyses revealed a more regulatory profile for rEos than for iEos, and correspondingly, mice lacking lung rEos showed an increase in Th2 cell responses to inhaled allergens. Such elevation of Th2 responses was linked to the ability of rEos, but not iEos, to inhibit the maturation, and therefore the pro-Th2 function, of allergen-loaded DCs. Finally, we determined that the parenchymal rEos found in nonasthmatic human lungs (Siglec-8+CD62L+IL-3Rlo cells) were phenotypically distinct from the iEos isolated from the sputa of eosinophilic asthmatic patients (Siglec-8+CD62LloIL-3Rhi cells), suggesting that our findings in mice are relevant to humans. In conclusion, our data define lung rEos as a distinct eosinophil subset with key homeostatic functions.
AU  - Mesnil,C
AU  - Raulier,S
AU  - Paulissen,G
AU  - Xiao,X
AU  - Birrell,MA
AU  - Pirottin,D
AU  - Janss,T
AU  - Starkl,P
AU  - Ramery,E
AU  - Henket,M
AU  - Schleich,FN
AU  - Radermecker,M
AU  - Thielemans,K
AU  - Gillet,L
AU  - Thiry,M
AU  - Belvisi,MG
AU  - Louis,R
AU  - Desmet,C
AU  - Marichal,T
AU  - Bureau,F
DO  - 10.1172/JCI85664
EP  - 3295
PY  - 2016///
SN  - 1558-8238
SP  - 3279
TI  - Lung-resident eosinophils represent a distinct regulatory eosinophil subset
T2  - Journal of Clinical Investigation
UR  - http://dx.doi.org/10.1172/JCI85664
UR  - http://hdl.handle.net/10044/1/39618
VL  - 126
ER  -
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