Imperial College London


Faculty of MedicineSchool of Public Health

Chair in Biostatistics



m.blangiardo Website




528Norfolk PlaceSt Mary's Campus






BibTex format

author = {Lavigne, A and Freni, Sterrantino A and Liverani, S and Blangiardo, M and De, hoogh K and Molitor, J and Hansell, A},
doi = {10.1136/bmjopen-2019-030140},
journal = {BMJ Open},
title = {Associations between metal constituents of ambient particulate matter and mortality in England; an ecological study},
url = {},
volume = {9},
year = {2019}

RIS format (EndNote, RefMan)

AB - Objectives To investigate long-term associations between metal components of particulate matter and mortality and lung cancer incidenceDesign Small area (ecological) study Setting Population living in all wards (~9000 individuals per ward) in the London and Oxford area of England, comprising 13.6 million individuals Exposure and Outcome measures We used land use regression (LUR) models originally used in the Transport related Air Pollution and Health impacts – Integrated Methodologies for Assessing Particulate Matter (TRANSPHORM) study to estimate exposure to copper, iron and zinc in ambient air particulate matter. We examined associations of metal exposure with Office for National Statistics mortality data from cardiovascular (CVD) and respiratory causes and with lung cancer incidence in 2008-11.Results There were 108,478 CVD deaths, 48,483 respiratory deaths and 24,849 incident cases of lung cancer in the study period and area. Using Poisson regression models adjusted for area-level deprivation, tobacco sales and ethnicity, we found associations between cardiovascular mortality and PM2.5 copper with interdecile range (IDR-2.6-5.7 ng/m3) and IDR Relative risk (RR) 1.005 (95%CI 1.001, 1.009) and between respiratory mortality and PM10 zinc (IDR 1135-153 ng/m3) and IDR RR 1.136 (95%CI 1.010, 1.277). We did not find relevant associations for lung cancer incidence. Metal elements were highly correlated.Conclusion Our analysis showed small but not fully consistent adverse associations between mortality and particulate metal exposures likely derived from non-tailpipe road traffic emissions (brake and tyre-wear), which have previously been associated with increases in inflammatory markers in the blood.
AU - Lavigne,A
AU - Freni,Sterrantino A
AU - Liverani,S
AU - Blangiardo,M
AU - De,hoogh K
AU - Molitor,J
AU - Hansell,A
DO - 10.1136/bmjopen-2019-030140
PY - 2019///
SN - 2044-6055
TI - Associations between metal constituents of ambient particulate matter and mortality in England; an ecological study
T2 - BMJ Open
UR -
UR -
VL - 9
ER -