Imperial College London


Faculty of MedicineSchool of Public Health

Chair in Biostatistics



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BibTex format

author = {Roca, Barcelo A and Douglas, P and Fecht, D and Freni, Sterrantino A and Williams, B and Blangiardo, M and Gulliver, J and Enda, T H and Hansell, A},
doi = {10.1016/j.envres.2019.108949},
journal = {Environmental Research},
pages = {1--10},
title = {Risk of respiratory hospital admission associated with modelled concentrations of Aspergillus fumigatus from composting facilities in England},
url = {},
volume = {183},
year = {2020}

RIS format (EndNote, RefMan)

AB - Bioaerosols have been associated with adverse respiratory-related health effects and are emitted in elevated concentrations from composting facilities. We usedmodelledAspergillus fumigatusconcentrations, a good indicator for bioaerosol emissions,to assess associations with respiratory-related hospital admissions. Mean dailyAspergillus fumigatusconcentrationswere estimated for each composting site for first full year of permit issuefrom2005 onwardsto 2014 for Census Output Areas (COAs) within 4km of 76 composting facilities in England, as previously described (Williams et al. 2019). We fitted ahierarchicalgeneralized mixed modelto examine therisk of hospital admission witha primary diagnosis of(i) any respiratory condition,(ii) respiratory infections,(iii) asthma,(iv) COPD,(v)diseases due to organic dust,and (vi)Cystic Fibrosis,inrelation to quartilesof Aspergillus fumigatusconcentrations. Models included a random intercept for each COAto account for over-dispersion,nested within composting facility, on whicha random intercept was fitted to account for clusteringof the data, with adjustmentsfor age, sex, ethnicity, deprivation, tobacco sales (smoking proxy) and traffic load (as a proxy for traffic-related air pollution). Weincluded 249,748 respiratory-related and 3,163 Cystic Fibrosis hospital admissions in 9,606 COAswith a population-weighted centroid within 4 km of the 76 included composting facilities. After adjustment for confounders, no statistically significant effect was observed for any respiratory-related (Relative Risk (RR)=0.99; 95% Confidence Interval (CI)0.96–1.01)or for Cystic Fibrosis (RR=1.01; 95% CI 0.56-1.83)hospital admissions for COAs in the highest quartile of exposure. Similar results were observed across all respiratory disease sub-groups.This study does not provide evidence for increased risks of respiratory-related hospitalisationsfor those livingnearcomposting facilities.However, given the limitations in the dispersion modelling, risks
AU - Roca,Barcelo A
AU - Douglas,P
AU - Fecht,D
AU - Freni,Sterrantino A
AU - Williams,B
AU - Blangiardo,M
AU - Gulliver,J
AU - Enda,T H
AU - Hansell,A
DO - 10.1016/j.envres.2019.108949
EP - 10
PY - 2020///
SN - 0013-9351
SP - 1
TI - Risk of respiratory hospital admission associated with modelled concentrations of Aspergillus fumigatus from composting facilities in England
T2 - Environmental Research
UR -
UR -
UR -
VL - 183
ER -