Imperial College London


Faculty of MedicineSchool of Public Health

Chair in Biostatistics



m.blangiardo Website




528Norfolk PlaceSt Mary's Campus






BibTex format

author = {Cai, Y and Hansell, AL and Granell, R and Blangiardo, M and Zottoli, M and Fecht, D and Gulliver, J and Henderson, AJ and Elliott, P},
doi = {10.1164/rccm.201902-0286OC},
journal = {American Journal of Respiratory and Critical Care Medicine},
pages = {112--123},
title = {Prenatal, early-life and childhood exposure to air pollution and lung function: the ALSPAC cohort},
url = {},
volume = {202},
year = {2020}

RIS format (EndNote, RefMan)

AB - RATIONALE: Exposure to air pollution during intrauterine development and through childhood may have lasting effects on respiratory health. OBJECTIVES: To investigate lung function at ages 8 and 15 years in relation to air pollution exposures during pregnancy, infancy and childhood in a UK population-based birth cohort. METHODS: Individual exposures to source-specific particulate matter with diameter ≤10µm (PM10) during each trimester, 0-6 months, 7-12 months (1990-1993) and up to age 15 years (1991-2008) were examined in relation to %predicted Forced expiratory volume in one second (FEV1) and forced vital capacity (FVC) at ages 8(N=5,276) and 15(N=3,446) years, usinglinear regression models adjusted for potential confounders. A profile regression model was used to identify sensitive time periods. MEASUREMENTS AND MAIN RESULTS: We did not find clear evidence for a sensitive exposure period for PM10 from road-traffic: at age 8 years, 1µg/m3 higher exposure during the first trimester was associated with lower %predicted of FEV1(-0.826, 95%CI:-1.357 to -0.296) and FVC(-0.817, 95%CI:-1.357 to -0.276), but similar associations were seen for exposures for other trimesters, 0-6 months, 7-12 months, and 0-7 years. Associations were stronger among boys, children whose mother had a lower education level or smoked during pregnancy. For PM10 from all sources, the third trimester was associated with lower %predicted of FVC (-1.312, 95%CI: -2.100 to -0.525). At age 15 years, no adverse associations were seen with lung function. CONCLUSIONS: Exposure to road-traffic PM10 during pregnancy may result in small but significant reductions in lung function at age 8 years.
AU - Cai,Y
AU - Hansell,AL
AU - Granell,R
AU - Blangiardo,M
AU - Zottoli,M
AU - Fecht,D
AU - Gulliver,J
AU - Henderson,AJ
AU - Elliott,P
DO - 10.1164/rccm.201902-0286OC
EP - 123
PY - 2020///
SN - 1073-449X
SP - 112
TI - Prenatal, early-life and childhood exposure to air pollution and lung function: the ALSPAC cohort
T2 - American Journal of Respiratory and Critical Care Medicine
UR -
UR -
UR -
UR -
VL - 202
ER -