Imperial College London

ProfessorMartaBlangiardo

Faculty of MedicineSchool of Public Health

Chair in Biostatistics
 
 
 
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Contact

 

m.blangiardo Website

 
 
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Location

 

528Norfolk PlaceSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Hansell:2016:10.1136/thoraxjnl-2015-207111,
author = {Hansell, A and Ghosh, RE and Blangiardo, M and Perkins, C and Vienneau, D and Goffe, K and Briggs, D and Gulliver, J},
doi = {10.1136/thoraxjnl-2015-207111},
journal = {Thorax},
pages = {330--338},
title = {Historic air pollution exposure and long-term mortality risks in England and Wales: prospective longitudinal cohort study},
url = {http://dx.doi.org/10.1136/thoraxjnl-2015-207111},
volume = {71},
year = {2016}
}

RIS format (EndNote, RefMan)

TY  - JOUR
AB - Introduction Long-term air pollution exposure contributes to mortality but there are few studies examining effects of very long-term (>25years) exposures.Methods This study investigated modelled air pollution concentrations at residence for 1971, 1981, 1991 (black smoke (BS) and SO2) and 2001 (PM10) in relation to mortality up to 2009 in 367658 members of the longitudinal survey, a 1% sample of the English Census. Outcomes were all-cause (excluding accidents), cardiovascular (CV) and respiratory mortality.Results BS and SO2 exposures remained associated with mortality decades after exposure—BS exposure in 1971 was significantly associated with all-cause (OR 1.02 (95% CI 1.01 to 1.04)) and respiratory (OR 1.05 (95% CI 1.01 to 1.09)) mortality in 2002–2009 (ORs expressed per 10 μg/m3). Largest effect sizes were seen for more recent exposures and for respiratory disease. PM10 exposure in 2001 was associated with all outcomes in 2002–2009 with stronger associations for respiratory (OR 1.22 (95% CI 1.04 to 1.44)) than CV mortality (OR 1.12 (95% CI 1.01 to 1.25)). Adjusting PM10 for past BS and SO2 exposures in 1971, 1981 and 1991 reduced the all-cause OR to 1.16 (95% CI 1.07 to 1.26) while CV and respiratory associations lost significance, suggesting confounding by past air pollution exposure, but there was no evidence for effect modification. Limitations include limited information on confounding by smoking and exposure misclassification of historic exposures.Conclusions This large national study suggests that air pollution exposure has long-term effects on mortality that persist decades after exposure, and that historic air pollution exposures influence current estimates of associations between air pollution and mortality.
AU - Hansell,A
AU - Ghosh,RE
AU - Blangiardo,M
AU - Perkins,C
AU - Vienneau,D
AU - Goffe,K
AU - Briggs,D
AU - Gulliver,J
DO - 10.1136/thoraxjnl-2015-207111
EP - 338
PY - 2016///
SN - 1468-3296
SP - 330
TI - Historic air pollution exposure and long-term mortality risks in England and Wales: prospective longitudinal cohort study
T2 - Thorax
UR - http://dx.doi.org/10.1136/thoraxjnl-2015-207111
UR - http://hdl.handle.net/10044/1/28349
VL - 71
ER -