Imperial College London
Alternate

ProfessorMarinaBotto

Faculty of Medicine, Department of Immunology and Inflammation

Head of Department, Director of Bioservices
 
 
 
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Contact

 

+44 (0)20 3313 2316m.botto Website

 
 
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Assistant

 

Miss Claudia Rocchi +44 (0)20 3313 2315

 
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Location

 

9N10Commonwealth BuildingHammersmith Campus

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Summary

 

Publications

Publication Type
Year
to

215 results found

Turnberg D, Botto M, Warren J, Morgan BP, Walport MJ, Cook Tet al., 2003, CD59a deficiency exacerbates accelerated nephrotoxic nephritis in mice, JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, Vol: 14, Pages: 2271-2279, ISSN: 1046-6673

Journal article

Di Gaetano N, Cittera E, Nota R, Vecchi A, Grieco V, Scanziani E, Botto M, Introna M, Golay Jet al., 2003, Complement activation determines the therapeutic activity of rituximab in vivo, JOURNAL OF IMMUNOLOGY, Vol: 171, Pages: 1581-1587, ISSN: 0022-1767

Journal article

Ten VS, Mazer SP, Minamoto K, Fedarau MA, Ratner VI, Botto M, Pinsky DJet al., 2003, Genetic deficiency of the complement component C1q protects neonatal mice against hypoxic ischemic encephalopathy (HIE), Annual Meeting of the Pediatric-Academic-Society, Publisher: INT PEDIATRIC RESEARCH FOUNDATION, INC, Pages: 541A-541A, ISSN: 0031-3998

Conference paper

Potter PK, Cortes-Hernandez J, Quartier P, Botto M, Walport MJet al., 2003, Lupus-prone mice have an abnormal response to thioglycolate and an impaired clearance of apoptotic cells, JOURNAL OF IMMUNOLOGY, Vol: 170, Pages: 3223-3232, ISSN: 0022-1767

Journal article

Brown JS, Hussell T, Gilliland SM, Holden DW, Paton JC, Ehrenstein MR, Walport MJ, Botto Met al., 2002, The classical pathway is the dominant complement pathway required for innate immunity to <i>Streptococcus pneumoniae</i> infection in mice, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Vol: 99, Pages: 16969-16974, ISSN: 0027-8424

Journal article

Cortes-Hernandez J, Fossati-Jimack L, Carugati A, Potter PK, Walport MJ, Cook HT, Botto Met al., 2002, Murine glomerular mesangial cell uptake of apoptotic cells is inefficient and involves serum-mediated but complement-independent mechanisms, CLINICAL AND EXPERIMENTAL IMMUNOLOGY, Vol: 130, Pages: 459-466, ISSN: 0009-9104

Journal article

Yamada M, Oritani K, Kaisho T, Ishikawa J, Yoshida H, Takahashi I, Kawamoto S, Ishida N, Ujiie H, Masaie H, Botto M, Tomiyama Y, Matsuzawa Yet al., 2002, Complement C1q suppresses lipopolysaccharide-induced cytokine production in bone marrow derived dendritic cells., 44th Annual Meeting of the American-Society-of-Hematology, Publisher: AMER SOC HEMATOLOGY, Pages: 462A-462A, ISSN: 0006-4971

Conference paper

Garlanda C, Hirsch E, Bozza S, Salustri A, De Acetis M, Nota R, Maccagno A, Riva F, Bottazzi B, Peri G, Doni A, Vago L, Botto M, De Santis R, Carminati P, Siracusa G, Altruda F, Vecchi A, Romani L, Mantovani Aet al., 2002, Non-redundant role of the long pentraxin PTX3 in anti-fungal innate immune response, NATURE, Vol: 420, Pages: 182-186, ISSN: 0028-0836

Journal article

Vandivier RW, Ogden CA, Fadok VA, Hoffmann PR, Brown KK, Botto M, Walport MJ, Fisher JH, Henson PM, Greene KEet al., 2002, Role of surfactant proteins D, D, and C1q in the clearance of apoptotic cells in vivo and in vitro: Calreticulin and CD91 as a common collectin receptor complex, JOURNAL OF IMMUNOLOGY, Vol: 169, Pages: 3978-3986, ISSN: 0022-1767

Journal article

Botto M, Walport MJ, 2002, C1q, autoimmunity and apoptosis, IMMUNOBIOLOGY, Vol: 205, Pages: 395-406, ISSN: 0171-2985

Journal article

Pickering MC, Cook HT, Warren J, Bygrave AE, Moss J, Walport MJ, Botto Met al., 2002, Uncontrolled C3 activation causes membranoproliferative glomerulonephritis in mice deficient in complement factor H, NATURE GENETICS, Vol: 31, Pages: 424-428, ISSN: 1061-4036

Journal article

Taylor PR, Pickering MC, Kosco-Vilbois MH, Walport MJ, Botto M, Gordon S, Martinez-Pomares Let al., 2002, The follicular dendritic cell restricted epitope, FDC-M2, is complement C4; localization of immune complexes in mouse tissues, EUROPEAN JOURNAL OF IMMUNOLOGY, Vol: 32, Pages: 1888-1896, ISSN: 0014-2980

Journal article

Tas SW, Fossati-Jimack L, Davies K, Botto M, Walport MJet al., 2002, ADHESION DEFECT AND IMPAIRED UPTAKE OF APOPTOTIC CELLS IN MACROPHAGES FROM SLE PATIENTS, RHEUMATOLOGY, Vol: 41, Pages: 29-30, ISSN: 1462-0324

Journal article

da Silveira SA, Kikuchi S, Fossati-Jimack L, Moll T, Saito T, Verbeek JS, Botto M, Walport MJ, Carroll M, Izui Set al., 2002, Complement activation selectively potentiates the pathogenicity of the IgG2b and IgG3 Isotypes of a high affinity anti-erythrocyte autoantibody, JOURNAL OF EXPERIMENTAL MEDICINE, Vol: 195, Pages: 665-672, ISSN: 0022-1007

Journal article

Mitchell DA, Pickering MC, Warren J, Fossati-Jimack L, Cortes-Hernandez J, Cook HT, Botto M, Walport MJet al., 2002, C1q deficiency and autoimmunity: The effects of genetic background on disease expression, JOURNAL OF IMMUNOLOGY, Vol: 168, Pages: 2538-2543, ISSN: 0022-1767

Journal article

Warren J, Mastroeni P, Dougan G, Noursadeghi M, Cohen J, Walport MJ, Botto Met al., 2002, Increased susceptibility of C1q-deficient mice to <i>Salmonella enterica</i> serovar Typhimurium infection, INFECTION AND IMMUNITY, Vol: 70, Pages: 551-557, ISSN: 0019-9567

Journal article

Celik I, Stover C, Botto M, Thiel S, Tzima S, Künkel D, Walport M, Lorenz W, Schwaeble Wet al., 2001, Role of the classical pathway of complement activation in experimentally induced polymicrobial peritonitis, INFECTION AND IMMUNITY, Vol: 69, Pages: 7304-7309, ISSN: 0019-9567

Journal article

Petry F, Botto M, Holtappels R, Walport MJ, Loos Met al., 2001, Reconstitution of the complement function in C1q-deficient (C1qa<SUP>-/-</SUP>) mice with wild-type bone marrow cells, JOURNAL OF IMMUNOLOGY, Vol: 167, Pages: 4033-4037, ISSN: 0022-1767

Journal article

Manderson AP, Pickering MC, Botto M, Walport MJ, Parish CRet al., 2001, Continual low-level activation of the classical complement pathway, Journal of Experimental Medicine, Vol: 194, Pages: 747-756, ISSN: 0022-1007

There is evidence that the classical complement pathway may be activated via a “C1-tickover” mechanism, analogous to the C3-tickover of the alternative pathway. We have quantitated and characterized this pathway of complement activation. Analysis of freshly collected mouse and human plasma revealed that spontaneous C3 activation rapidly occurred with the generation of C3 fragments in the plasma. By the use of complement- and Ig-deficient mice it was found that C1q, C4, C2, and plasma Ig were all required for this spontaneous C3 activation, with the alternative complement pathway further amplifying C3 fragment generation. Study of plasma from a human with C1q deficiency before and after therapeutic C1q infusion confirmed the existence of a similar pathway for complement activation in humans. Elevated levels of plasma C3 were detected in mice deficient in complement components required for activation of either the classical or alternative complement pathways, supporting the hypothesis that there is continuous complement activation and C3 consumption through both these pathways in vivo. Blood stasis was found to stimulate C3 activation by classical pathway tick-over. This antigen-independent mechanism for classical pathway activation may augment activation of the complement system at sites of inflammation and infarction.

Journal article

Holt DS, Botto M, Bygrave AE, Hanna SM, Walport MJ, Morgan BPet al., 2001, Targeted deletion of the CD59 gene causes spontaneous intravascular hemolysis and hemoglobinuria, BLOOD, Vol: 98, Pages: 442-449, ISSN: 0006-4971

Journal article

Cutler AJ, Cornall RJ, Ferry H, Manderson AP, Botto M, Walport MJet al., 2001, Intact B cell tolerance in the absence of the first component of the classical complement pathway, EUROPEAN JOURNAL OF IMMUNOLOGY, Vol: 31, Pages: 2087-2093, ISSN: 0014-2980

Journal article

Pickering MC, Fischer S, Lewis MR, Walport MJ, Botto M, Cook HTet al., 2001, Ultraviolet-radiation-induced keratinocyte apoptosis in C1q-deficient mice, JOURNAL OF INVESTIGATIVE DERMATOLOGY, Vol: 117, Pages: 52-58, ISSN: 0022-202X

Journal article

Robson MG, Cook HT, Botto M, Taylor PR, Busso N, Salvi R, Pusey CD, Walport MJ, Davies KAet al., 2001, Accelerated nephrotoxic nephritis is exacerbated in C1q-deficient mice, JOURNAL OF IMMUNOLOGY, Vol: 166, Pages: 6820-6828, ISSN: 0022-1767

Journal article

Taylor PR, Seixas E, Walport MJ, Langhorne J, Botto Met al., 2001, Complement contributes to protective immunity against reinfection by <i>Plasmodium chabaudi chabaudi</i> parasites, INFECTION AND IMMUNITY, Vol: 69, Pages: 3853-3859, ISSN: 0019-9567

Journal article

Mabbott NA, Bruce ME, Botto M, Walport MJ, Pepys MBet al., 2001, Temporary depletion of complement component C3 or genetic deficiency of C1q significantly delays onset of scrapie, NATURE MEDICINE, Vol: 7, Pages: 485-487, ISSN: 1078-8956

Journal article

Klein MA, Kaeser PS, Schwarz P, Weyd H, Xenarios I, Zinkernagel RM, Carroll MC, Verbeek JS, Botto M, Walport MJ, Molina H, Kalinke U, Acha-Orbea H, Aguzzi Aet al., 2001, Complement facilitates early prion pathogenesis, NATURE MEDICINE, Vol: 7, Pages: 488-492, ISSN: 1078-8956

Journal article

Nash JT, Taylor PR, Botto M, Norsworthy PJ, Davies KA, Walport MJet al., 2001, Immune complex processing in C1q-deficient mice, CLINICAL AND EXPERIMENTAL IMMUNOLOGY, Vol: 123, Pages: 196-202, ISSN: 0009-9104

Journal article

Botto M, 2001, Links between complement deficiency and apoptosis, ARTHRITIS RESEARCH & THERAPY, Vol: 3, ISSN: 1478-6354

Journal article

Pickering MC, Botto M, Taylor PR, Lachmann PJ, Walport MJet al., 2001, Systemic lupus erythematosus, complement deficiency, and apoptosis, ADVANCES IN IMMUNOLOGY, VOL. 76, Vol: 76, Pages: 227-324, ISSN: 0065-2776

Journal article

Botto M, 2001, Links between complement deficiency and apoptosis, ARTHRITIS RESEARCH, Vol: 3, Pages: 207-210, ISSN: 1465-9913

Journal article

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