Imperial College London
Alternate

ProfessorMarinaBotto

Faculty of Medicine, Department of Immunology and Inflammation

Head of Department, Director of Bioservices
 
 
 
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Contact

 

+44 (0)20 3313 2316m.botto Website

 
 
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Assistant

 

Miss Claudia Rocchi +44 (0)20 3313 2315

 
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Location

 

9N10Commonwealth BuildingHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Giacomassi:2016:10.1016/j.jid.2016.11.011,
author = {Giacomassi, C and Buang, N and Ling, GS and Crawford, G and Cook and Scott, D and Dazzi, F and Strid and Botto, M},
doi = {10.1016/j.jid.2016.11.011},
journal = {Journal of Investigative Dermatology},
pages = {760--763},
title = {Complement C3 exacerbates imiquimod-induced skin inflammation and psoriasiform dermatitis},
url = {http://dx.doi.org/10.1016/j.jid.2016.11.011},
volume = {137},
year = {2016}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - The  complement  system  is  pivotal  in protection  against  pathogens,  but  also  plays  important  roles  in  bridging  innate  and  adaptive  immune  responses  (Scott  and  Botto,  2015)  and  in  modulating local and systemic inflammation (Markiewski and Lambris, 2007). Activation of complement  occurs  through  three  different  pathways  (classical,  alternative  and  lectin),  converges at C3 cleavage and culminates in the formation of the membrane attack complex. The anaphylotoxic fragments, C3a and C5a, generated during the proteolytic cascade, recruit immune cells that can promote the removal of debris and pathogens, but can also cause tissue damage (Markiewski and Lambris, 2007).
AU  - Giacomassi,C
AU  - Buang,N
AU  - Ling,GS
AU  - Crawford,G
AU  - Cook
AU  - Scott,D
AU  - Dazzi,F
AU  - Strid
AU  - Botto,M
DO  - 10.1016/j.jid.2016.11.011
EP  - 763
PY  - 2016///
SN  - 1523-1747
SP  - 760
TI  - Complement C3 exacerbates imiquimod-induced skin inflammation and psoriasiform dermatitis
T2  - Journal of Investigative Dermatology
UR  - http://dx.doi.org/10.1016/j.jid.2016.11.011
UR  - http://hdl.handle.net/10044/1/42608
VL  - 137
ER  -
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