Summary
Martyn Boutelle trained at Imperial College gaining a PhD in electrochemistry with John Albery FRS in the Department of Chemistry. He then moved to Physiology at the University of Oxford where he worked with Marianne Fillenz and Allen Hill FRS in the interdisciplinary area of in vivo monitoring of the brain using electrochemical sensors. His work there lead to an interest in brain metabolism, and monitoring extracellular neurochemistry with high time resolution by use of microelectrodes and on-line microdialysis. This was extended to clinical monitoring of the brain in 1995 when he moved to the Department of Chemistry, King’s College where he was a Lecturer then Reader in Biomedical Analysis. He joined Imperial College in December 2004.
He now works closely with neurosurgeons at King’s College Hospital, bowel and kidney surgeons at Imperial College, and Maxillofacial surgeons at Queen Alexandra's Hospital Portsmouth on the use of on-line microdialysis to detect transient ischaemia, and the development of new clinical monitoring techniques. These techniques combine electrochemical biosensors in novel microfludic devices with other real-time measurements such as tissue oxygen, electrical activity, blood pressure and flow to give multimodal monitoring.
He is a founder member of COSBID (www.cosbid.org), a grouping of clinicians and fundamental scientists interested in the role of spontaneous brain depolarisations in the maturation of brain injury.
Martyn’s research publications can be found at the tab above, or on Google Scholar
Selected Publications
Journal Articles
Robbins EM, Jaquins-Gerstl A, Fine DF, et al., 2019, Extended (10-Day) Real-Time Monitoring by Dexamethasone-Enhanced Microdialysis in the Injured Rat Cortex., Acs Chem Neurosci, Vol:10, Pages:3521-3531
Gowers S, Rogers M, Booth M, et al., 2019, Clinical translation of microfluidic sensor devices: Focus on calibration and analytical robustness, Lab on a Chip, Vol:19, ISSN:1473-0189, Pages:2537-2548
Nightingale AM, Leong CL, Burnish RA, et al., 2019, Monitoring biomolecule concentrations in tissue using a wearable droplet microfluidic-based sensor, Nature Communications, Vol:10, ISSN:2041-1723, Pages:1-12
Samper I, Gowers S, Rogers M, et al., 2019, 3D printed microfluidic device for online detection of dynamic metabolite concentration changes with high temporal resolution in human brain microdialysate, Lab on a Chip, Vol:19, ISSN:1473-0189, Pages:2038-2048
Pagkalos I, Rogers M, Boutelle MG, et al., 2018, A high-performance application specific integrated circuit for electrical and neurochemical traumatic brain injury monitoring, Chemphyschem, Vol:19, ISSN:1439-4235, Pages:1215-1225
Boutelle MG, Gowers SAN, Hamaoui K, et al., 2018, High temporal resolution delayed analysis of clinical microdialysate streams, Analyst, Vol:143, ISSN:1364-5528, Pages:715-724
Booth MA, Gowers SAN, Leong CL, et al., 2017, Chemical Monitoring in Clinical Settings: Recent Developments toward Real-Time Chemical Monitoring of Patients., Analytical Chemistry, Vol:90, ISSN:0003-2700, Pages:2-18
Varner EL, Leong CL, Jaquins-Gerstl A, et al., 2017, Enhancing continuous online microdialysis using dexamethasone: measurement of dynamic neurometabolic changes during spreading depolarization, ACS Chemical Neuroscience, Vol:8, ISSN:1948-7193, Pages:1779-1788
Rogers ML, Leong CL, Gowers SAN, et al., 2017, Simultaneous monitoring of potassium, glucose and lactate during spreading depolarisation in the injured human brain - proof of principle of a novel real-time neurochemical analysis system, continuous online microdialysis, Journal of Cerebral Blood Flow and Metabolism, Vol:37, ISSN:1559-7016, Pages:1883-1895
Phairatana T, Leong CL, Gowers SAN, et al., 2016, Real-time detection of carboplatin using a microfluidic system, Analyst, Vol:141, ISSN:0003-2654, Pages:6270-6277
Papadimitriou K, Wang C, Rogers M, et al., 2016, High-Performance Bioinstrumentation for Real-Time Neuroelectrochemical Traumatic Brain Injury Monitoring, Frontiers in Human Neuroscience, Vol:10, ISSN:1662-5161
Gowers SAN, Curto VF, Seneci CA, et al., 2015, A 3D printed microfluidic device with integrated biosensors for online analysis of subcutaneous human microdialysate, Analytical Chemistry, Vol:87, ISSN:0003-2700, Pages:7763-7770
Hutchinson PJ, Jalloh I, Helmy A, et al., 2015, Consensus statement from the 2014 International Microdialysis Forum., Intensive Care Medicine, Vol:41, ISSN:1432-1238, Pages:1517-1528
Jeffcote T, Hinzman JM, Jewell SL, et al., 2014, Detection of spreading depolarization with intraparenchymal electrodes in the injured human brain, Neurocritical Care, Vol:20, ISSN:1541-6933, Pages:21-31
Rogers ML, Feuerstein D, Leong CL, et al., 2013, Continuous Online Microdialysis Using Microfluidic Sensors: Dynamic Neurometabolic Changes during Spreading Depolarization, ACS Chemical Neuroscience, Vol:4, ISSN:1948-7193, Pages:799-807
Rogers ML, Brennan PA, Leong CL, et al., 2013, Online rapid sampling microdialysis (rsMD) using enzyme-based electroanalysis for dynamic detection of ischaemia during free flap reconstructive surgery, Analytical and Bioanalytical Chemistry, Vol:405, ISSN:1618-2642, Pages:3881-3888
Feuerstein D, Manning A, Hashemi P, et al., 2010, Dynamic metabolic response to multiple spreading depolarizations in patients with acute brain injury: an online microdialysis study, Journal of Cerebral Blood Flow and Metabolism, Vol:30, ISSN:0271-678X, Pages:1343-1355
Feuerstein D, Parker KH, Boutelle MG, 2009, Practical Methods for Noise Removal: Applications to Spikes, Nonstationary Quasi-Periodic Noise, and Baseline Drift, Analytical Chemistry, Vol:81, ISSN:0003-2700, Pages:4987-4994
Hashemi P, Bhatia R, Nakamura H, et al., 2009, Persisting depletion of brain glucose following cortical spreading depression, despite apparent hyperaemia: evidence for risk of an adverse effect of Leao's spreading depression, Journal of Cerebral Blood Flow and Metabolism, Vol:29, ISSN:0271-678X, Pages:166-175
Fabricius M, Fuhr S, Willumsen L, et al., 2008, Association of seizures with cortical spreading depression and peri-infarct depolarisations in the acutely injured human brain, Clinical Neurophysiology, Vol:119, ISSN:1388-2457, Pages:1973-1984
Caesar K, Hashemi P, Douhou A, et al., 2008, Glutamate receptor-dependent increments in lactate, glucose and oxygen metabolism evoked in rat cerebellum <i>in vivo</i>, Journal of Physiology - London, Vol:586, ISSN:0022-3751, Pages:1337-1349