Publications
199 results found
Córcoles EP, Boutelle MG, 2013, Microdialysis monitoring, SpringerBriefs in Applied Sciences and Technology, Pages: 63-73
Microdialysis advancement from research tool to clinical device occurred during the early 1990s when CMA Microdialysis (Solna, Sweden) marketed the microdialysis catheter and the bedside dialysate analyser. Since then, microdialysis has been recognised as an important technique for point of care and home care monitoring. Microdialysis advantages over other point of care devices are manifested through the continuous sampling and the absence of intensive human intervention.
Córcoles EP, Boutelle MG, 2013, Conclusion and future trends, SpringerBriefs in Applied Sciences and Technology, Pages: 75-77
With the advance in nanotechnology and the use of materials such as silicon and CNT with excellent mechanical, optical and electrochemical properties, the factor that prevents the widespread use of implantable devices for clinical monitoring is their low reliability.
Córcoles EP, Boutelle MG, 2013, Further information and advice, SpringerBriefs in Applied Sciences and Technology, Pages: 79-80
Research in implantable devices is progressing at a fast rate. Glucose implantable devices are at the forefront of this technology due to the high demand for diabetes management. Diabetes research news, blogs and website links present some of the latest commercialised or in process of being commercialised technology.
Córcoles EP, Boutelle MG, 2013, Invasive sampling, SpringerBriefs in Applied Sciences and Technology, Pages: 43-44
The most commonly used invasive methods in clinical practice today are dialysis and central catheters to deliver medication and continuously monitor patient’s circulatory status.
Córcoles EP, Boutelle MG, 2013, Requirements for an invasive sensor, SpringerBriefs in Applied Sciences and Technology, Pages: 5-13
Biosensors are defined as analytical devices that combine a biological component (biorecognition) with a physicochemical detector (transducer) capable of converting the analyte into a quantifiable signal. Biosensors for in vivo monitoring have been extensively studied and the literature contains a vast amount of papers describing biosensor’s features, requirements and applications.
Rogers ML, Boutelle MG, 2013, Real-Time Clinical Monitoring of Biomolecules, ANNUAL REVIEW OF ANALYTICAL CHEMISTRY, VOL 6, Vol: 6, Pages: 427-453, ISSN: 1936-1327
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- Citations: 34
Corcoles EP, Boutelle MG, Deeba S, et al., 2012, Monitoring the effect of hypoxia in bowel dialysate metabolites levels with online biosensors, 2012 International Conference on Biomedical Engineering, ICoBE 2012, Pages: 60-62
The intestinal tract is one of the main organs that, after hemorrhage or shock, appears to be involved in an ischemic/reperfusion injury. Metabolic substances, such as glucose and lactate are useful measurements for the monitoring of intestinal ischemia, since this provokes variation of intracellular biochemical markers. In order to identify the ischemic/reperfusion mechanism adequately, physiological monitoring of the bowel under a different stress condition is required. Biomarkers were monitored during hypoxic conditions induced in a swine model to investigate the effect of this physiological variable on metabolic rates. Results showed that hypoxia could have different effects on bowel dialysate metabolites levels depending on tissue capabilities. © 2012 IEEE.
Corcoles EP, Deeba S, Hanna GB, et al., 2011, Measurements of bowel microdialysis recovery with an online biosensor system, Proceedings - International Conference on Instrumentation, Communication, Information Technology and Biomedical Engineering 2011, ICICI-BME 2011, Pages: 361-365
Microdialysis is a sampling technique based on the passive diffusion of the molecules through a small segment of cylindrical hollow fiber membrane implanted within the tissue of study. Calibration of the microdialysis probe and the parameters that affect this calibration are essential, since recovery factors are never 100%. In vitro calibration methods are typically used to compare the concentration of the outlet with the concentration of the medium. In vivo quantification methods of microdialysis data monitoring depends on active and passive tissue effects, complicating the calibration methods further. In vitro and in vivo microdialysis calibration methods were performed in gastrointestinal tissue of animal models and intensive care patients. Results showed that the discrepancy between in vitro and in vivo calibration method is minimal. © 2011 IEEE.
Corcoles EP, Deeba S, Damji S, et al., 2011, Rapid sampling microdialysis monitorign of post aortic repair intestinal ischemia, JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, Vol: 26, Pages: 192-193, ISSN: 0815-9319
Corcoles EP, Deeba S, Hanna GB, et al., 2011, Use of online rapid sampling microdialysis electrochemical biosensor for bowel anastomosis monitoring in swine model, ANALYTICAL METHODS, Vol: 3, Pages: 2010-2016, ISSN: 1759-9660
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- Citations: 5
Damji S, Hamaoui K, Chang Y-M, et al., 2011, ORGAN VIABILITY ASSESSMENT IN THE PRESERVATION PERIOD UTILISING RAPID SAMPLING MICRODIALYSIS, TRANSPLANT INTERNATIONAL, Vol: 24, Pages: 197-197, ISSN: 0934-0874
Damji S, Hamaoui K, Bullock N, et al., 2011, ONLINE RAPID SAMPLING MICRODIALYSIS (rsMD) FOR VIABILITY ASSESSMENT, COMPARING STATIC COLD STORAGE VERSUS HYPOTHERMIC MACHINE PERFUSION IN MARGINAL ALLOGRAFTS, TRANSPLANT INTERNATIONAL, Vol: 24, Pages: 350-351, ISSN: 0934-0874
Patel BA, Rogers M, Wieder T, et al., 2011, ATP microelectrode biosensor for stable long-term <i>in vitro</i> monitoring from gastrointestinal tissue, BIOSENSORS & BIOELECTRONICS, Vol: 26, Pages: 2890-2896, ISSN: 0956-5663
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- Citations: 47
Corcoles EP, Deeb S, Hanna G, et al., 2011, Adaptation of on-line rapid sampling microdialysis to monitor human intestinal ischaemia, Jurnal Teknologi (Sciences and Engineering), Vol: 54, Pages: 47-59, ISSN: 0127-9696
Intestinal ischaemia or poor perfusion of the gastrointestinal tract is a major cause of post-operative mortality in abdominal surgery. Currently diagnosis of ischaemia relies only on clinical symptoms. Thus, monitoring bowel metabolism as an early marker of intestinal ischaemia is necessary. Human bowel microdialysis has been used in the past to study the metabolism of ichaemia collecting dialysate samples from the peritoneal cavity every 60 minutes. These sampling times carry a long delay for the detection of the typically rapid ischaemic event. We have previously developed a successful biosensor system to monitor neurochemicals in the human brain during surgery and in the intensive care unit The method consists of a flow injection analysis (FIA) system coupled to an enzyme based amperometric detector. The rapid sampling microdialysis monitoring system analysed electrochemically the dialysate glucose and lactate at high time resolution (typically 30 second sampling). Adaptation of the analytical assay system for on-line microdialysis monitoring of human bowel was performed and validated for in vivo procedures. Optimum membranes loading ratios were found to be 1:0.5 GOx:HRP and 2:0.5 LOx:HRP. The ischemic range was found to be 15μM-400μM, 40μM-6mM for glucose and lactate, respectively. The calibration method for these monitorings was concluded with a range from 250 μM to 6 mM. © Universiti Teknologi Malaysia.
Corcoles EP, Deeba S, Hanna GB, et al., 2011, Bowel Ischemia Monitoring Using Rapid Sampling Microdialysis Biosensor System, 5TH KUALA LUMPUR INTERNATIONAL CONFERENCE ON BIOMEDICAL ENGINEERING 2011 (BIOMED 2011), Vol: 35, Pages: 275-+, ISSN: 1680-0737
Rogers M, Leong C, Niu X, et al., 2011, Optimisation of a microfluidic analysis chamber for the placement of microelectrodes, PHYSICAL CHEMISTRY CHEMICAL PHYSICS, Vol: 13, Pages: 5298-5303, ISSN: 1463-9076
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- Citations: 22
Feuerstein D, Manning A, Hashemi P, et al., 2010, Dynamic metabolic response to multiple spreading depolarizations in patients with acute brain injury: an online microdialysis study, JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, Vol: 30, Pages: 1343-1355, ISSN: 0271-678X
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- Citations: 94
Deeba S, Corcoles E, Hanna GB, et al., 2009, Translational research: The use of rapid sampling microdialysis for bedside monitoring of bowel ischemia, 95th Annual Clinical Congress of the American-College-of-Surgeons/64th Annual Sessions of the Owen H Wangensteen Forum on Fundamental Surgical Problems, Publisher: ELSEVIER SCIENCE INC, Pages: S19-S20, ISSN: 1072-7515
Forsyth R, Fray A, Boutelle M, et al., 2009, A role for astrocytes in glucose delivery to neurons?, DEVELOPMENTAL NEUROSCIENCE, Vol: 18, Pages: 360-370, ISSN: 0378-5866
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- Citations: 48
Feuerstein D, Parker KH, Boutelle MG, 2009, Practical Methods for Noise Removal: Applications to Spikes, Nonstationary Quasi-Periodic Noise, and Baseline Drift, ANALYTICAL CHEMISTRY, Vol: 81, Pages: 4987-4994, ISSN: 0003-2700
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- Citations: 53
Hashemi P, Bhatia R, Nakamura H, et al., 2009, Persisting depletion of brain glucose following cortical spreading depression, despite apparent hyperaemia: evidence for risk of an adverse effect of Leao's spreading depression, JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, Vol: 29, Pages: 166-175, ISSN: 0271-678X
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- Citations: 81
Feuerstein D, Manning A, Hashemi P, et al., 2009, Local dynamic metabolic response to spontaneous spreading depolarisations in the penumbra of the acutely injured human brain, Brain 09, Publisher: Nature Publishing, Pages: S57-S57, ISSN: 0271-678X
Deeba S, Corcoles EP, Hanna GB, et al., 2008, Use of rapid sampling microdialysis for intraoperative monitoring of bowel ischemia (Diseases of the Colon and Rectum DOI: 10.1007/s10350-008-9375-4), Diseases of the Colon and Rectum, Vol: 51, ISSN: 0012-3706
Deeba S, Corcoles EP, Hanna BG, et al., 2008, Use of rapid sampling microdialysis for intraoperative monitoring of bowel ischemia, DISEASES OF THE COLON & RECTUM, Vol: 51, Pages: 1408-1413, ISSN: 0012-3706
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- Citations: 36
Fabricius M, Fuhr S, Willumsen L, et al., 2008, Association of seizures with cortical spreading depression and peri-infarct depolarisations in the acutely injured human brain, CLINICAL NEUROPHYSIOLOGY, Vol: 119, Pages: 1973-1984, ISSN: 1388-2457
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- Citations: 162
Caesar K, Hashemi P, Douhou A, et al., 2008, Glutamate receptor-dependent increments in lactate, glucose and oxygen metabolism evoked in rat cerebellum <i>in vivo</i>, JOURNAL OF PHYSIOLOGY-LONDON, Vol: 586, Pages: 1337-1349, ISSN: 0022-3751
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- Citations: 83
Fabricius M, Fuhr S, Willumsen L, et al., 2007, Cortical spreading depression and seizures co-occur after acute brain injury, 61st Annual Meeting of the American-Epilepsy-Society, Publisher: BLACKWELL PUBLISHING, Pages: 249-249, ISSN: 0013-9580
Bhatia R, Chen N, Boutelle MG, et al., 2006, A. potentiometric flow-through device for measuring potassium levels in microdialysate: Potential application to ionic monitoring in TBI, 8th International Neurotrauma Symposium, Publisher: MARY ANN LIEBERT INC, Pages: 754-754, ISSN: 0897-7151
Strong AJ, Bezzina EL, Anderson PJB, et al., 2006, Evaluation of laser speckle flowmetry for imaging cortical perfusion in experimental stroke studies: quantitation of perfusion and detection of peri-infarct depolarisations, JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, Vol: 26, Pages: 645-653, ISSN: 0271-678X
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- Citations: 66
Bhatia R, Hashemi P, Razzaq A, et al., 2006, Application of rapid-sampling, online microdialysis to the monitoring of brain metabolism during aneurysm surgery, NEUROSURGERY, Vol: 58, Pages: 313-320, ISSN: 0148-396X
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- Citations: 30
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