Imperial College London
Alternate

ProfessorMartynBoutelle

Faculty of Engineering, Department of Bioengineering

Associate Provost (Estates Planning)
 
 
 
//

Contact

 

+44 (0)20 7594 5138m.boutelle Website CV

 
 
//

Location

 

B208Bessemer BuildingSouth Kensington Campus

//

Summary

 

Publications

Citation

BibTex format

@article{Nightingale:2019:10.1038/s41467-019-10401-y,
author = {Nightingale, AM and Leong, CL and Burnish, RA and Hassan, S-U and Zhang, Y and Clough, GF and Boutelle, MG and Voegeli, D and Niu, X},
doi = {10.1038/s41467-019-10401-y},
journal = {Nature Communications},
pages = {1--12},
title = {Monitoring biomolecule concentrations in tissue using a wearable droplet microfluidic-based sensor},
url = {http://dx.doi.org/10.1038/s41467-019-10401-y},
volume = {10},
year = {2019}
}
Download

RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Knowing how biomarker levels vary within biological fluids over time can produce valuable insight into tissue physiology and pathology, and could inform personalised clinical treatment. We describe here a wearable sensor for monitoring biomolecule levels that combines continuous fluid sampling with in situ analysis using wet-chemical assays (with the specific assay interchangeable depending on the target biomolecule). The microfluidic device employs a droplet flow regime to maximise the temporal response of the device, using a screw-driven push-pull peristaltic micropump to robustly produce nanolitre-sized droplets. The fully integrated sensor is contained within a small (palm-sized) footprint, is fully autonomous, and features high measurement frequency (a measurement every few seconds) meaning deviations from steady-state levels are quickly detected. We demonstrate how the sensor can track perturbed glucose and lactate levels in dermal tissue with results in close agreement with standard off-line analysis and consistent with changes in peripheral blood levels.
AU  - Nightingale,AM
AU  - Leong,CL
AU  - Burnish,RA
AU  - Hassan,S-U
AU  - Zhang,Y
AU  - Clough,GF
AU  - Boutelle,MG
AU  - Voegeli,D
AU  - Niu,X
DO  - 10.1038/s41467-019-10401-y
EP  - 12
PY  - 2019///
SN  - 2041-1723
SP  - 1
TI  - Monitoring biomolecule concentrations in tissue using a wearable droplet microfluidic-based sensor
T2  - Nature Communications
UR  - http://dx.doi.org/10.1038/s41467-019-10401-y
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000472480500008&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - https://www.nature.com/articles/s41467-019-10401-y
UR  - http://hdl.handle.net/10044/1/71331
VL  - 10
ER  -
Download