Imperial College London
Alternate

ProfessorMartynBoutelle

Faculty of Engineering, Department of Bioengineering

Associate Provost (Estates Planning)
 
 
 
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Contact

 

+44 (0)20 7594 5138m.boutelle Website CV

 
 
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Location

 

B208Bessemer BuildingSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Robbins:2019:10.1021/acschemneuro.9b00145,
author = {Robbins, EM and Jaquins-Gerstl, A and Fine, DF and Leong, CL and Dixon, CE and Wagner, AK and Boutelle, MG and Michael, AC},
doi = {10.1021/acschemneuro.9b00145},
journal = {ACS Chem Neurosci},
pages = {3521--3531},
title = {Extended (10-Day) Real-Time Monitoring by Dexamethasone-Enhanced Microdialysis in the Injured Rat Cortex.},
url = {http://dx.doi.org/10.1021/acschemneuro.9b00145},
volume = {10},
year = {2019}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Intracerebral microdialysis has proven useful for chemical monitoring in patients following traumatic brain injury. Recent studies in animals, however, have documented that insertion of microdialysis probes into brain tissues initiates a foreign-body response. Within a few days after probe insertion, the foreign body response impedes the use of microdialysis to monitor the K+ and glucose transients associated with spreading depolarization, a potential mechanism for secondary brain injury. Herein, we show that perfusing microdialysis probes with dexamethasone, a potent anti-inflammatory glucocorticoid, suppresses the foreign body response and facilitates the monitoring of spontaneous spreading depolarizations for at least 10 days following controlled cortical injury in the rat. In addition to spreading depolarizations, results of this study suggest that a progressive, apparently permanent, decline in pericontusional interstitial glucose may be an additional sequela of brain injury. This study establishes extended dexamethasone-enhanced microdialysis in the injured rodent cortex as a new paradigm for investigating trauma-induced metabolic crisis.
AU  - Robbins,EM
AU  - Jaquins-Gerstl,A
AU  - Fine,DF
AU  - Leong,CL
AU  - Dixon,CE
AU  - Wagner,AK
AU  - Boutelle,MG
AU  - Michael,AC
DO  - 10.1021/acschemneuro.9b00145
EP  - 3531
PY  - 2019///
SP  - 3521
TI  - Extended (10-Day) Real-Time Monitoring by Dexamethasone-Enhanced Microdialysis in the Injured Rat Cortex.
T2  - ACS Chem Neurosci
UR  - http://dx.doi.org/10.1021/acschemneuro.9b00145
UR  - https://www.ncbi.nlm.nih.gov/pubmed/31246409
VL  - 10
ER  -
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