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@article{Bashford:2020:10.1002/mus.26864,
author = {Bashford, J and Masood, U and Wickham, A and Iniesta, R and Drakakis, E and Boutelle, M and Mills, K and Shaw, C},
doi = {10.1002/mus.26864},
journal = {Muscle and Nerve},
pages = {745--750},
title = {Fasciculations demonstrate daytime consistency in amyotrophic lateral sclerosis},
url = {http://dx.doi.org/10.1002/mus.26864},
volume = {61},
year = {2020}
}

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TY  - JOUR
AB  - IntroductionFasciculations represent early neuronal hyperexcitability in amyotrophic lateral sclerosis (ALS). To aid calibration as a disease biomarker, we set out to characterize the daytime variability of fasciculation firing.MethodsFasciculation awareness scores were compiled from 19 ALS patients. In addition, 10 ALS patients prospectively underwent highdensity surface electromyographic (HDSEMG) recordings from biceps and gastrocnemius at three timepoints during a single day.ResultsDaytime fasciculation awareness scores were low (mean: 0.28 muscle groups), demonstrating significant variability (coefficient of variation: 303%). Biceps HDSEMG recordings were highly consistent for fasciculation potential frequency (intraclass correlation coefficient [ICC] = 95%, n = 19) and the interquartile range of fasciculation potential amplitude (ICC = 95%, n = 19). These parameters exhibited robustness to observed fluctuations in data quality parameters. Gastrocnemius demonstrated more modest levels of consistency overall (44% to 62%, n = 20).DiscussionThere was remarkable daytime consistency of fasciculation firing in the biceps of ALS patients, despite sparse and intermittent awareness among patients’ accounts.
AU  - Bashford,J
AU  - Masood,U
AU  - Wickham,A
AU  - Iniesta,R
AU  - Drakakis,E
AU  - Boutelle,M
AU  - Mills,K
AU  - Shaw,C
DO  - 10.1002/mus.26864
EP  - 750
PY  - 2020///
SN  - 0148-639X
SP  - 745
TI  - Fasciculations demonstrate daytime consistency in amyotrophic lateral sclerosis
T2  - Muscle and Nerve
UR  - http://dx.doi.org/10.1002/mus.26864
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000525390900001&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - https://onlinelibrary.wiley.com/doi/full/10.1002/mus.26864
UR  - http://hdl.handle.net/10044/1/82402
VL  - 61
ER  -

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