Imperial College London


Faculty of EngineeringDepartment of Bioengineering

Associate Provost (Estates Planning)



+44 (0)20 7594 5138m.boutelle Website CV




B208Bessemer BuildingSouth Kensington Campus





My biomedical monitoring research group is multidisciplinary, embracing both the development of fundamental physical/ analytical science methods and the use of these new techniques in a programme of neuroscience and clinical science research. My approach is to combine real-time measurement of neurochemical, electrical and physical measurements such as blood flow and local brain pressure to give a clear picture of the dynamics of tissue response to stimulation or trauma. The same measurement techniques are used in patients and in experimental models allowing genuine translational research.

Measurement methodologies

Tissue Sampling

  • Real-time microdialysis

  • Microfabricated microdialysis sampling probes

  • ‘Smart’ catheters and drains

  • Digital microfluidics - microfabricated flow-segmentation devices for microdialysis

  • Detection of molecular biomarker

  • Ion selective electrodes
  • Microelectrode based biosensors
  • Design of low noise computerised instrumentation
  • Noise reduction algorithms
  • low volume on-line flow cells for digital microfluidics
  • Measurement for other tissue signals

  • Measurement of brain electrical activity - electrocoticography , full band EEG
  • Measurement of local blood flow using laser speckle methods
  • Data fusion from different real-time measurement techniques
  • Clinical and neuroscience research

  • Clinical detection and characterisation of spontaneous electrical depolarisation waves in traumatic brain injury patients.
  • Clinical monitoring of neurochemistry in brain injury in traumatic brain injury patients
  • Translational study of transient neurochemical mechanisms underlying brain injury
  • Development of energy budgets for neurotransmission
  • Clinical monitoring of ‘at risk’ bowel during and following surgery
  • Development of monitoring system for transplanted kidneys
  • Development of a point of care test for obstetric choliastasis  - a key risk factor for the development of pre-eclampsia in pregnant women
  • Detection of Ischaemia during free-flap surgery using rapid-sampling microdialysis
  • My research has recently been funded by

    Wellcome Trust / Department of Health Healthcare Innovation Challange Fund  - ' Real-time detection of the onset of secondary brain injury in the intensive care unit.'

    Imperial College Biomedical Research Centre (BRC) - 'Device for the early detection of bowel ischemia and sepsis – a proof of concept study'

    BBSRC - CASE award with Sharp europe - 'Development of Sensors for Obstetric Medicine'

    BBSRC CASE award with GSk PLC - 'Development of biosensor technology for the measurement of brain neurotransmitters implicated in memory loss'

    BBSRC, Wellcome Trust,  Max Plank Society, GSk PLC, Head First.


    Professor Peter Brennan, Queen Alexandra Hospital, Portsmouth, Real-time monitoring of ischaemia during Free flap Surgery, 2011

    Professor Helle Waegepetersen, Danish Pharmaceutical University

    Professor Martin Lauritzen, Panum Physiology Institute, Copenhagen, and Glostrup Hospital, Copenhagen

    Professor Rudolf Graff, Deputy Director, Planck Institute of Neuropsychology, Cologne, Germany

    Dr Danny O’Hare, Department of Bioengineering, Imperial College London

    Dr Christos Papavassiliou, EE department, Imperial College London

    Mr George Hanna and Professor Sir Ara Dazi, St Mary’s Hospital London

    Dr Rob Lamertink, University of Twente, Holland

    Professor Anthony Strong, Department of academic Neurosurgery, King's College London, Neurosurgery / Neuroscience

    Research Staff



    Research Student Supervision

    Bagha,N, Reactive oxygen and biosensors

    CORCOLES,E, Detection of bowel and brain ischaemia using rapid sampling microdialysis

    Chang,Y-M, Microdialysis assay to detect bowel and kidney ischaemia

    FEUERSTEIN,D, Development of analysis methods for rapid clinical monitoring

    Ganhdhi,S, Microfludic methods for determination of buffer capacity

    Gowers,S, Device for the early detection of ischaemia in transplant kidneys and bowel

    Jeffcote,DT, The role of spreading depolarizations in human secondary brain injury

    Lawrence,D, Biosensors for obstetric medicine

    Leong,A, Flow segmentation of microdialysis streams coupled to microelectrode biosensors - on-chip detection of tissue biomarker dynamics.

    Mulcahy,S, Critical information retrieval from multi-variate clinical data

    Rogers,M, Development of biosensor technology for the measurement of brain neurotransmitters implicated in memory loss.

    Wang,C, New Instrumentation for real-time chemical analysis

    kontojannis,DV, Detection of SD waves in the human brain using NIRS