My biomedical monitoring research group is multidisciplinary, embracing both the development of fundamental physical/ analytical science methods and the use of these new techniques in a programme of neuroscience and clinical science research. My approach is to combine real-time measurement of neurochemical, electrical and physical measurements such as blood flow and local brain pressure to give a clear picture of the dynamics of tissue response to stimulation or trauma. The same measurement techniques are used in patients and in experimental models allowing genuine translational research.
Microfabricated microdialysis sampling probes
‘Smart’ catheters and drains
Digital microfluidics - microfabricated flow-segmentation devices for microdialysis
Detection of molecular biomarker
Measurement for other tissue signals
Clinical and neuroscience research
My research has recently been funded by
Wellcome Trust / Department of Health Healthcare Innovation Challange Fund - ' Real-time detection of the onset of secondary brain injury in the intensive care unit.'
Imperial College Biomedical Research Centre (BRC) - 'Device for the early detection of bowel ischemia and sepsis – a proof of concept study'
BBSRC - CASE award with Sharp europe - 'Development of Sensors for Obstetric Medicine'
BBSRC CASE award with GSk PLC - 'Development of biosensor technology for the measurement of brain neurotransmitters implicated in memory loss'
BBSRC, Wellcome Trust, Max Plank Society, GSk PLC, Head First.
Professor Peter Brennan, Queen Alexandra Hospital, Portsmouth, Real-time monitoring of ischaemia during Free flap Surgery, 2011
Professor Helle Waegepetersen, Danish Pharmaceutical University
Professor Martin Lauritzen, Panum Physiology Institute, Copenhagen, and Glostrup Hospital, Copenhagen
Professor Rudolf Graff, Deputy Director, Planck Institute of Neuropsychology, Cologne, Germany
Dr Danny O’Hare, Department of Bioengineering, Imperial College London
Dr Christos Papavassiliou, EE department, Imperial College London
Mr George Hanna and Professor Sir Ara Dazi, St Mary’s Hospital London
Dr Rob Lamertink, University of Twente, Holland
Professor Anthony Strong, Department of academic Neurosurgery, King's College London, Neurosurgery / Neuroscience
Research Student Supervision
Bagha,N, Reactive oxygen and biosensors
CORCOLES,E, Detection of bowel and brain ischaemia using rapid sampling microdialysis
Chang,Y-M, Microdialysis assay to detect bowel and kidney ischaemia
FEUERSTEIN,D, Development of analysis methods for rapid clinical monitoring
Ganhdhi,S, Microfludic methods for determination of buffer capacity
Gowers,S, Device for the early detection of ischaemia in transplant kidneys and bowel
Jeffcote,DT, The role of spreading depolarizations in human secondary brain injury
Lawrence,D, Biosensors for obstetric medicine
Leong,A, Flow segmentation of microdialysis streams coupled to microelectrode biosensors - on-chip detection of tissue biomarker dynamics.
Mulcahy,S, Critical information retrieval from multi-variate clinical data
Rogers,M, Development of biosensor technology for the measurement of brain neurotransmitters implicated in memory loss.
Wang,C, New Instrumentation for real-time chemical analysis
kontojannis,DV, Detection of SD waves in the human brain using NIRS