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@article{Engl:2016:nar/gkw628,
author = {Engl, C and Schafer, J and Kotta-Loizou, I and Buck, M},
doi = {nar/gkw628},
journal = {Nucleic Acids Research},
pages = {9933--9941},
title = {Cellular and molecular phenotypes depending upon the RNA repair system RtcAB of Escherichia coli},
url = {http://dx.doi.org/10.1093/nar/gkw628},
volume = {44},
year = {2016}
}

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TY  - JOUR
AB  - RNA ligases function pervasively across the three kingdoms of life for RNA repair, splicing and can be stress induced. The RtcB protein (also HSPC117, C22orf28, FAAP and D10Wsu52e) is one such conserved ligase, involved in tRNA and mRNA splicing. However, its physiological role is poorly described, especially in bacteria. We now show in Escherichia coli bacteria that the RtcR activated rtcAB genes function for ribosome homeostasis involving rRNA stability. Expression of rtcAB is activated by agents and genetic lesions which impair the translation apparatus or may cause oxidative damage in the cell. Rtc helps the cell to survive challenges to the translation apparatus, including ribosome targeting antibiotics. Further, loss of Rtc causes profound changes in chemotaxis and motility. Together, our data suggest that the Rtc system is part of a previously unrecognized adaptive response linking ribosome homeostasis with basic cell physiology and behaviour.
AU  - Engl,C
AU  - Schafer,J
AU  - Kotta-Loizou,I
AU  - Buck,M
DO  - nar/gkw628
EP  - 9941
PY  - 2016///
SN  - 1362-4962
SP  - 9933
TI  - Cellular and molecular phenotypes depending upon the RNA repair system RtcAB of Escherichia coli
T2  - Nucleic Acids Research
UR  - http://dx.doi.org/10.1093/nar/gkw628
UR  - http://hdl.handle.net/10044/1/37125
VL  - 44
ER  -

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