Imperial College London
Alternate

Professor Martin Buck FRS

Faculty of Natural Sciences, Department of Life Sciences

Senior Research Investigator
 
 
 
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Contact

 

+44 (0)20 7594 5442m.buck

 
 
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Location

 

448Sir Alexander Fleming BuildingSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Bradley:2016:10.1016/j.mib.2016.07.004,
author = {Bradley, RW and Buck, M and Wang, B},
doi = {10.1016/j.mib.2016.07.004},
journal = {Current Opinion in Microbiology},
pages = {74--82},
title = {Recognizing and engineering digital-like logic gates and switches in gene regulatory networks},
url = {http://dx.doi.org/10.1016/j.mib.2016.07.004},
volume = {33},
year = {2016}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - A central aim of synthetic biology is to build organisms that can perform useful activities in response to specified conditions. The digital computing paradigm which has proved so successful in electrical engineering is being mapped to synthetic biological systems to allow them to make such decisions. However, stochastic molecular processes have graded input-output functions, thus, bioengineers must select those with desirable characteristics and refine their transfer functions to build logic gates with digital-like switching behaviour. Recent efforts in genome mining and the development of programmable RNA-based switches, especially CRISPRi, have greatly increased the number of parts available to synthetic biologists. Improvements to the digital characteristics of these parts are required to enable robust predictable design of deeply layered logic circuits.
AU  - Bradley,RW
AU  - Buck,M
AU  - Wang,B
DO  - 10.1016/j.mib.2016.07.004
EP  - 82
PY  - 2016///
SN  - 1879-0364
SP  - 74
TI  - Recognizing and engineering digital-like logic gates and switches in gene regulatory networks
T2  - Current Opinion in Microbiology
UR  - http://dx.doi.org/10.1016/j.mib.2016.07.004
UR  - http://hdl.handle.net/10044/1/37396
VL  - 33
ER  -
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