Imperial College London
Alternate

Prof Marc Chadeau-Hyam

Faculty of Medicine, School of Public Health

Professor of Computational Epidemiology and Biostatistics
 
 
 
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Contact

 

+44 (0)20 7594 1637m.chadeau

 
 
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Location

 

520Medical SchoolSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Chadeau:2020:10.2217/epi-2019-0261,
author = {Chadeau, M and Castagne, R and Kelly-Irving, M and Krogh, V and Palli, D and Sacerdote, C and Tumino, R and Hebbels, D and Kleinjans, J and de, Kok T and Georgiadis, P and Kyrtopoulos, S and Vermeulen, R and Stringhini, S and Vineis, P and Delpierre, C},
doi = {10.2217/epi-2019-0261},
journal = {Epigenomics},
title = {A multi-omics approach to investigate the inflammatory response to life course socioeconomic position},
url = {http://dx.doi.org/10.2217/epi-2019-0261},
volume = {12},
year = {2020}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Aims: Inflammation represents a potential pathway through which socioeconomic position (SEP) is biologically embedded. Materials & Methods: We analysed inflammatory biomarkers in response to life course SEP by integrating multi-omics DNA-methylation, gene expression and protein level in 178 EPIC-Italy participants. Results & Conclusions: We identified 61 potential cis acting CpG loci whose methylation levels were associated with gene expression at a Bonferroni correction. We examined the relationships between life course SEP and these 61 cis-acting regulatory methylation sites (eMS) individually and jointly using several scores. Less advantaged SEP participants exhibit, later in life, a lower inflammatory methylome score, suggesting an overall increased expression of the corresponding inflammatory genes or proteins, supporting the hypothesis that SEP impacts adult physiology through inflammation.
AU  - Chadeau,M
AU  - Castagne,R
AU  - Kelly-Irving,M
AU  - Krogh,V
AU  - Palli,D
AU  - Sacerdote,C
AU  - Tumino,R
AU  - Hebbels,D
AU  - Kleinjans,J
AU  - de,Kok T
AU  - Georgiadis,P
AU  - Kyrtopoulos,S
AU  - Vermeulen,R
AU  - Stringhini,S
AU  - Vineis,P
AU  - Delpierre,C
DO  - 10.2217/epi-2019-0261
PY  - 2020///
SN  - 1750-1911
TI  - A multi-omics approach to investigate the inflammatory response to life course socioeconomic position
T2  - Epigenomics
UR  - http://dx.doi.org/10.2217/epi-2019-0261
UR  - http://hdl.handle.net/10044/1/81208
VL  - 12
ER  -
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