Imperial College London
Alternate

Prof Marc Chadeau-Hyam

Faculty of Medicine, School of Public Health

Professor of Computational Epidemiology and Biostatistics
 
 
 
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Contact

 

+44 (0)20 7594 1637m.chadeau

 
 
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Location

 

520Medical SchoolSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Maurel:2020:10.1016/j.bbi.2020.09.002,
author = {Maurel, M and Castagné, R and Berger, E and Bochud, M and Chadeau-Hyam, M and Fraga, S and Gandini, M and Hutri-Kähönen, N and Jalkanen, S and Kivimäki, M and Marmot, M and McCrory, C and Preisig, M and Raitakari, O and Ricceri, F and Salmi, M and Steptoe, A and Vineis, P and Delpierre, C and Kelly-Irving, M},
doi = {10.1016/j.bbi.2020.09.002},
journal = {Brain, Behavior, and Immunity},
pages = {303--310},
title = {Patterning of educational attainment across inflammatory markers: Findings from a multi-cohort study},
url = {http://dx.doi.org/10.1016/j.bbi.2020.09.002},
volume = {90},
year = {2020}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - BACKGROUND: Evidence suggests that the inflammatory reaction, an adaptive response triggered by a variety of harmful stimuli and conditions involved in the risk and development of many chronic diseases, is a potential pathway through which the socioeconomic environment is biologically embedded. Difficulty in interpreting the role of the inflammatory system in the embodiment dynamic arises because of heterogeneity across studies that use a limited but varied number of inflammatory markers. There is no consensus in the literature as to which inflammatory markers beyond the C-reactive protein and to a lesser extent interleukin 6 are related to the social environment. Accordingly, we aimed to investigate the association between educational attainment, and several markers of inflammation - C-reactive protein, fibrinogen, interleukin 6, interleukin 1β and tumor necrosis factor α- in 6 European cohort studies. METHODS: Up to 17,470 participants from six European cohort studies with data on educational attainment, health behaviors and lifestyle factors, and at least two different inflammatory markers. Four sub-datasets were drawn with varying numbers of participants to allow pairwise comparison of the social patterning of C-reactive protein and any other inflammatory markers. To evaluate within each sub-dataset the importance of the context and cohort specificities, linear regression-based analyses were performed separately for each cohort and combined in a random effect meta-analysis to determine the relationship between educational attainment and inflammation. RESULTS: We found that the magnitude of the relationship between educational attainment and five inflammatory biomarkers (C-reactive protein, fibrinogen, interleukin 6 and 1β and tumor necrosis factor α) was variable. By far the most socially patterned biomarker was C-reactive protein, followed by fibrinogen and to lesser extent interleukin 6, where a low educational attainment was associated w
AU  - Maurel,M
AU  - Castagné,R
AU  - Berger,E
AU  - Bochud,M
AU  - Chadeau-Hyam,M
AU  - Fraga,S
AU  - Gandini,M
AU  - Hutri-Kähönen,N
AU  - Jalkanen,S
AU  - Kivimäki,M
AU  - Marmot,M
AU  - McCrory,C
AU  - Preisig,M
AU  - Raitakari,O
AU  - Ricceri,F
AU  - Salmi,M
AU  - Steptoe,A
AU  - Vineis,P
AU  - Delpierre,C
AU  - Kelly-Irving,M
DO  - 10.1016/j.bbi.2020.09.002
EP  - 310
PY  - 2020///
SN  - 0889-1591
SP  - 303
TI  - Patterning of educational attainment across inflammatory markers: Findings from a multi-cohort study
T2  - Brain, Behavior, and Immunity
UR  - http://dx.doi.org/10.1016/j.bbi.2020.09.002
UR  - https://www.ncbi.nlm.nih.gov/pubmed/32919037
UR  - http://hdl.handle.net/10044/1/83100
VL  - 90
ER  -
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