Imperial College London
Alternate

Prof Marc Chadeau-Hyam

Faculty of Medicine, School of Public Health

Professor of Computational Epidemiology and Biostatistics
 
 
 
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Contact

 

+44 (0)20 7594 1637m.chadeau

 
 
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Location

 

520Medical SchoolSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Said:2022:10.1038/s41467-022-29650-5,
author = {Said, S and Karhunen, V and vosa, U and ligthart, S and Bodinier, B and Koskeridis, F and welsh, P and Alizadeh, B and Daniel, C and sattar, N and Chadeau, M and evalgelou, E and Jarvelin, M-R and Elliott, P and Tzoulaki, I and Dehghan, A},
doi = {10.1038/s41467-022-29650-5},
journal = {Nature Communications},
title = {Genetic analysis of over half a million people characterises C-reactive protein loci},
url = {http://dx.doi.org/10.1038/s41467-022-29650-5},
volume = {13},
year = {2022}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Chronic low-grade inflammation is linked to a multitude of chronic diseases. We report the largest genome-wide association study (GWAS) on C-reactive protein (CRP), a marker of systemic inflammation, in UK Biobank participants (N = 427,367, European descent) and the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium (total N = 575,531 European descent). We identify 266 independent loci, of which 211 are not previously reported. Gene-set analysis highlighted 42 gene sets associated with CRP levels (p ≤ 3.2 ×10−6) and tissue expression analysis indicated a strong association of CRP related genes with liver and whole blood gene expression. Phenome-wide association study identified 27 clinical outcomes associated with genetically determined CRP and subsequent Mendelian randomisation analyses supported a causal association with schizophrenia, chronic airway obstruction and prostate cancer. Our findings identified genetic loci and functional properties of chronic low-grade inflammation and provided evidence for causal associations with a range of diseases.
AU  - Said,S
AU  - Karhunen,V
AU  - vosa,U
AU  - ligthart,S
AU  - Bodinier,B
AU  - Koskeridis,F
AU  - welsh,P
AU  - Alizadeh,B
AU  - Daniel,C
AU  - sattar,N
AU  - Chadeau,M
AU  - evalgelou,E
AU  - Jarvelin,M-R
AU  - Elliott,P
AU  - Tzoulaki,I
AU  - Dehghan,A
DO  - 10.1038/s41467-022-29650-5
PY  - 2022///
SN  - 2041-1723
TI  - Genetic analysis of over half a million people characterises C-reactive protein loci
T2  - Nature Communications
UR  - http://dx.doi.org/10.1038/s41467-022-29650-5
UR  - http://hdl.handle.net/10044/1/96684
VL  - 13
ER  -
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