Summary
Child lab Research Interests
Our lab uses modern chemical biology techniques to increase our understanding of the basic biology of intracellular pathogens such as Toxoplasma and Plasmodium.
We use drug-like small molecules to ask questions about the interaction of these pathogenic organisms with their chosen host-cell. We do this in the belief that by increasing our understanding we will be better equipped to target and therapeutically treat infections that impact human health.
For more information visit www.laboratorychild.com/
About Dr. Matthew Child
Matthew studied for a PhD in molecular parasitology with Prof. Mike Blackman at the National Institute for Medical Research, London, UK. Afterhis PhD, he moved to the USA to continue his academic career as a post-doc in the chemical biology-focused laboratory of Prof. Matt Bogyo at Stanford University, California.
Following his return to the UK, Matthew was awarded a Wellcome Trust and Royal Society Sir Henry Dale Fellowship, allowing him to initiate his independent research career and lab at Imperial College London.
Publications
Journals
Benns HJ, Storch M, Falco JA, et al., 2022, CRISPR-based oligo recombineering prioritizes apicomplexan cysteines for drug discovery., Nat Microbiol
Kolli SK, Molina-Cruz A, Araki T, et al., 2022, Malaria parasite evades mosquito immunity by glutaminyl cyclase-mediated posttranslational protein modification., Proc Natl Acad Sci U S A, Vol:119
Wincott CJ, Sritharan G, Benns HJ, et al., 2022, Cellular barcoding of protozoan pathogens reveals the within-host population dynamics of Toxoplasma gondii host colonization, Cell Reports Methods, Vol:2, ISSN:2667-2375, Pages:1-16
Jeffers V, Child MA, 2022, No acetyl-CoA keeps Plasmodium at bay, Cell Chemical Biology, Vol:29, ISSN:2451-9456, Pages:174-176
Alves E, Benns H, Magnus L, et al., 2021, An extracellular redox signal triggers calcium release and impacts the asexual development of Toxoplasma gondii, Frontiers in Cellular and Infection Microbiology, Vol:11, ISSN:2235-2988, Pages:1-14