Child lab Research Interests
Our lab uses modern chemical biology techniques to increase our understanding of the basic biology of intracellular pathogens such as Toxoplasma and Plasmodium.
We use drug-like small molecules to ask questions about the interaction of these pathogenic organisms with their chosen host-cell. We do this in the belief that by increasing our understanding we will be better equipped to target and therapeutically treat infections that impact human health.
For more information visit www.laboratorychild.com/
About Dr. Matthew Child
Matthew studied for a PhD in molecular parasitology with Prof. Mike Blackman at the National Institute for Medical Research, London, UK. Afterhis PhD, he moved to the USA to continue his academic career as a post-doc in the chemical biology-focused laboratory of Prof. Matt Bogyo at Stanford University, California.
Following his return to the UK, Matthew was awarded a Wellcome Trust and Royal Society Sir Henry Dale Fellowship, allowing him to initiate his independent research career and lab at Imperial College London.
et al., 2020, CRISPR-TAPE: protein-centric CRISPR guide design for targeted proteome engineering., Mol Syst Biol, Vol:16
Benns HJ, Tate EW, Child MA, 2018, Activity-Based Protein Profiling for the Study of Parasite Biology., Curr Top Microbiol Immunol, Vol:420, ISSN:0070-217X, Pages:155-174
et al., 2018, Development of an activity-based probe for acyl-protein thioesterases, Plos One, Vol:13, ISSN:1932-6203
et al., 2017, Toxoplasma DJ-1 Regulates Organelle Secretion by a Direct Interaction with Calcium-Dependent Protein Kinase 1, Mbio, Vol:8, ISSN:2150-7511
et al., 2015, Global Analysis of Palmitoylated Proteins in Toxoplasma gondii, Cell Host & Microbe, Vol:18, ISSN:1931-3128, Pages:501-511