Child lab Research Interests
Our lab uses modern chemical biology techniques to increase our understanding of the basic biology of intracellular pathogens such as Toxoplasma and Plasmodium.
We use drug-like small molecules to ask questions about the interaction of these pathogenic organisms with their chosen host-cell. We do this in the belief that by increasing our understanding we will be better equipped to target and therapeutically treat infections that impact human health.
For more information visit www.laboratorychild.com/
About Dr. Matthew Child
Matthew studied for a PhD in molecular parasitology with Prof. Mike Blackman at the National Institute for Medical Research, London, UK. Afterhis PhD, he moved to the USA to continue his academic career as a post-doc in the chemical biology-focused laboratory of Prof. Matt Bogyo at Stanford University, California.
Following his return to the UK, Matthew was awarded a Wellcome Trust and Royal Society Sir Henry Dale Fellowship, allowing him to initiate his independent research career and lab at Imperial College London.
Benns HJ, Tate EW, Child MA, 2018, Activity-Based Protein Profiling for the Study of Parasite Biology., Curr Top Microbiol Immunol, Vol:420, ISSN:0070-217X, Pages:155-174
et al., 2018, Development of an activity-based probe for acyl-protein thioesterases, Plos One, Vol:13, ISSN:1932-6203
et al., 2017, Toxoplasma DJ-1 Regulates Organelle Secretion by a Direct Interaction with Calcium-Dependent Protein Kinase 1, Mbio, Vol:8, ISSN:2150-7511
et al., 2015, Global Analysis of Palmitoylated Proteins in Toxoplasma gondii, Cell Host & Microbe, Vol:18, ISSN:1931-3128, Pages:501-511
et al., 2015, A small-molecule antivirulence agent for treating Clostridium difficile infection, Science Translational Medicine, Vol:7, ISSN:1946-6234