I am a lecturer within the Computational and Systems Medicine Section of the Department of Surgery and Cancer. My research interests include the application of metabonomics in toxicology, with a particular focus on mechanistic toxicology and the study of adverse drug reactions and variable response phenotypes. My research involves the application of advanced analytical technologies that include both NMR spectroscopy and mass spectrometry to characterise endogenous and xenobiotic metabolic profiles reflecting response to toxicity at a systems level. I am currently researching hepatotoxicity associated with galactosamine, tienilic acid and teinilic acid isomer, isoniazid and methotrexate together with aminoglycoside nephrotoxicity in both in vivo models and the clinical setting.
I was awarded an MRC Integrative Toxicology Training Partnership (ITTP) career development fellowship (2009-2012) and continue to work closely with the MRC ITTP scheme through inter-disciplinary PhD studentships.
I am also leading the Imperial College research that forms part of the EU FP7 project, HELIX (The Human Early-Life Exposome – novel tools for integrating early-life environmental exposures and child health across Europe). The HELIX project consortium will exploit novel tools and methods, including ‘omics and smartphone-based personal exposure monitoring, to characterise early-life exposure to a wide range of environmental hazards. The totality of environmental (non-genetic) exposures from conception until old age is defined as the ‘exposome’. HELIX will utilize extensive biobanks collected from multiple mother-child cohorts across Europe and will integrate novel exposome data with child health outcomes.
Further details can be found on the HELIX website.
I am a member of the Royal Society of Chemistry’s Toxicology Group Committee. I am a member of the British Toxicology Society and was awarded the Early Career Investigator Award in 2010.