Publications
226 results found
Guo L, Normando EM, Nizari S, et al., 2010, Tracking Longitudinal Retinal Changes in Experimental Ocular Hypertension Using the cSLO and Spectral Domain-OCT, INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, Vol: 51, Pages: 6504-6513, ISSN: 0146-0404
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- Citations: 67
Baltmr A, Duggan J, Nizari S, et al., 2010, Neuroprotection in glaucoma - Is there a future role?, EXPERIMENTAL EYE RESEARCH, Vol: 91, Pages: 554-566, ISSN: 0014-4835
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- Citations: 122
Georgiou AL, Guo L, Cordeiro MF, et al., 2010, Changes in NMDA receptor contribution to synaptic transmission in the brain in a rat model of glaucoma, NEUROBIOLOGY OF DISEASE, Vol: 39, Pages: 344-351, ISSN: 0969-9961
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- Citations: 11
Jungkim S, Ahmed F, Levy J, et al., 2010, A Novel Way of Identifying Stable Glaucoma and Ocular Hypertension Using an Electronic Medical Record System (Medisoft®ERS), Publisher: ASSOC RESEARCH VISION OPHTHALMOLOGY INC, ISSN: 0146-0404
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- Citations: 1
Guo L, Nizari S, Normando FM, et al., 2010, Amyloid-β and Tau Pathology in the Retina of a Triple-Transgenic Model of Alzheimer's Disease (3xTg-AD), Publisher: ASSOC RESEARCH VISION OPHTHALMOLOGY INC, ISSN: 0146-0404
Baltmr AM, Salt TE, Cordeiro MF, 2010, Potential Targets for Ginkgo Biloba Neuroprotective Effects in a Rat Glaucoma Model; Cytochrome c, APP and Aβeta, Publisher: ASSOC RESEARCH VISION OPHTHALMOLOGY INC, ISSN: 0146-0404
Cordeiro MF, Guo L, Coxon KM, et al., 2010, Retinal Neurodegeneration in Alzheimer's Disease - Novel in vivo Assessment of Triple Transgenic Model, Publisher: ASSOC RESEARCH VISION OPHTHALMOLOGY INC, ISSN: 0146-0404
Normando EM, Guo L, Nizari S, et al., 2010, In vivo Imaging for Quantification of RGC and Retinal Structural Changes in Experimental Glaucoma With OCT Spectralis, Publisher: ASSOC RESEARCH VISION OPHTHALMOLOGY INC, ISSN: 0146-0404
Liu M, Guo L, Salt TE, et al., 2010, Dendritic Changes in the Retinal Ganglion Cells in a Rat Model of Experimental Glaucoma, Publisher: ASSOC RESEARCH VISION OPHTHALMOLOGY INC, ISSN: 0146-0404
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- Citations: 1
Guo L, Duggan J, Cordeiro MF, 2010, Alzheimer's Disease and Retinal Neurodegeneration, CURRENT ALZHEIMER RESEARCH, Vol: 7, Pages: 3-14, ISSN: 1567-2050
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- Citations: 128
Cordeiro MF, Guo L, Coxon KM, et al., 2010, Imaging multiple phases of neurodegeneration: a novel approach to assessing cell death in vivo, Cell Death and Disease, Vol: 1, ISSN: 2041-4889
Nerve cell death is the key event in all neurodegenerative disorders, with apoptosis and necrosis being central to both acute and chronic degenerative processes. However, until now, it has not been possible to study these dynamically and in real time. In this study, we use spectrally distinct, well-recognised fluorescent cell death markers to enable the temporal resolution and quantification of the early and late phases of apoptosis and necrosis of single nerve cells in different disease models. The tracking of single-cell death profiles in the same living eye over hours, days, weeks and months is a significant advancement on currently available techniques. We identified a numerical preponderance of late-phase versus early-phase apoptotic cells in chronic models, reinforcing the commonalities between cellular mechanisms in different disease models. We showed that MK801 effectively inhibited both apoptosis and necrosis, but our findings support the use of our technique to investigate more specific anti-apoptotic and anti-necrotic strategies with well-defined targets, with potentially greater clinical application. The optical properties of the eye provide compelling opportunities for the quantitative monitoring of disease mechanisms and dynamics in experimental neurodegeneration. Our findings also help to directly observe retinal nerve cell death in patients as an adjunct to refining diagnosis, tracking disease status and assessing therapeutic intervention.
Schmitz-Valckenberg S, Guo L, Cheung W, et al., 2010, In vivo imaging of retinal cell apoptosis following acute light exposure, OPHTHALMOLOGE, Vol: 107, Pages: 22-29, ISSN: 0941-293X
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- Citations: 13
Schmitz-Valckenberg S, Cordeiro MF, Fitzke FW, et al., 2010, Toward Molecular Imaging, MEDICAL RETINA: FOCUS ON RETINAL IMAGING, Editors: Holz, Spaide, Publisher: SPRINGER-VERLAG BERLIN, Pages: 217-222, ISBN: 978-3-540-85539-2
Normando EM, Coxon KM, Guo L, et al., 2009, Focus on: Amyloid β, EXPERIMENTAL EYE RESEARCH, Vol: 89, Pages: 446-447, ISSN: 0014-4835
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- Citations: 9
Cordeiro MF, Nickells R, Drexler W, et al., 2009, High-Resolution Ocular Imaging: Combining Advanced Optics and Microtechnology, OPHTHALMIC SURGERY LASERS & IMAGING, Vol: 40, Pages: 480-488, ISSN: 1542-8877
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- Citations: 7
Borrie SC, Duggan J, Cordeiro MF, 2009, Retinal cell apoptosis, Expert Review of Ophthalmology, Vol: 4, Pages: 27-45, ISSN: 1746-9899
Apoptosis in retinal cell populations has been detected in a wide range of eye diseases causing blindness. Compared to necrosis, apoptosis is an early maker of disease and represents a controlled form of cell death. It is now known that multiple pathways, including oxidative stress and nitric oxide synthase, and both mitochondrial-mediated caspase-dependent and -independent mechanisms are involved, with variations dependent on disease and cell type. The retina offers a compact and easily accessible route by which to examine these processes. The aim of this review is to appraise what is known about the apoptotic cell death pathways that are involved in important blinding retinal diseases, by considering results from animal models of retinal diseases and how they can relate to the human disease. Animal models have offered the opportunity to examine pathways of cell death in far greater detail than is possible in humans. Particular emphasis will be on the different intracellular mechanisms by which apoptosis leads to retinal neuronal death in animal models of retinal disease and whether this can be applied to the human disease, since understanding this is critical for developing therapies. These will encompass retinal dystrophies, age-related macular degeneration, glaucoma and diabetic retinopathy. Key challenges for treatment of retinal diseases will be targeting multiple pathways of apoptosis to effectively rescue cells and restore function. © 2009 Expert Reviews Ltd.
Schmitz-Valckenberg S, Guo L, Maass A, et al., 2008, Real-time in vivo imaging of retinal cell apoptosis after laser exposure, Annual Meeting of the Association-for-Research-in-Vision-and-Ophthalmology, Publisher: ASSOC RESEARCH VISION OPHTHALMOLOGY INC, Pages: 2773-2780, ISSN: 0146-0404
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- Citations: 45
Cheung W, Guo L, Cordeiro MF, 2008, Neuroprotection in glaucoma: Drug-based approaches, OPTOMETRY AND VISION SCIENCE, Vol: 85, Pages: 406-416, ISSN: 1040-5488
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- Citations: 75
Guo L, Cordeiro MF, 2008, Assessment of neuroprotection in the retina with DARC, GLAUCOMA: AN OPEN WINDOW TO NEURODEGENERATION AND NEUROPROTECTION, Editors: Nucci, Cerulli, Osborne, Bagetta, Publisher: ELSEVIER SCIENCE BV, Pages: 437-450
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- Citations: 48
Cordeiro MF, 2007, DARC: a new method for detecting progressive neuronal death, Conference on New Avenues towards Glaucoma Management, Publisher: NATURE PUBLISHING GROUP, Pages: S15-S17, ISSN: 0950-222X
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- Citations: 9
Cordeiro MF, Erskine L, 2007, Back to basics - ephrins, axonal guidance, neuroprotection and glaucoma, BRITISH JOURNAL OF OPHTHALMOLOGY, Vol: 91, Pages: 1106-1106, ISSN: 0007-1161
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- Citations: 6
Guo L, Salt TE, Luong V, et al., 2007, Targeting amyloid-β in glaucoma treatment, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Vol: 104, Pages: 13444-13449, ISSN: 0027-8424
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- Citations: 266
Kalev-Landoy M, Day AC, Cordeiro MF, et al., 2007, Optical coherence tomography in anterior segment imaging, ACTA OPHTHALMOLOGICA SCANDINAVICA, Vol: 85, Pages: 427-430, ISSN: 1395-3907
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- Citations: 35
Maass A, von Leithner PL, Luong V, et al., 2007, Assessment of rat and mouse RGC apoptosis Imaging <i>in Vivo</i> with different scanning laser ophthalmoscopes, CURRENT EYE RESEARCH, Vol: 32, Pages: 851-861, ISSN: 0271-3683
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- Citations: 56
Salt TE, Cordeiro MF, 2006, Sir, Glutamate excitotoxicity in glaucoma: throwing the baby out with the bathwater?, EYE, Vol: 20, Pages: 730-731, ISSN: 0950-222X
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- Citations: 36
Salt TE, Cordeiro MF, 2006, Glutamate excitotoxicity in glaucoma: throwing the baby out with the bathwater?, Eye (Lond), Vol: 20, Pages: 730-731, ISSN: 0950-222X
Guo L, Salt TE, Maass A, et al., 2006, Assessment of neuroprotective effects of glutamate modulation on glaucoma-related retinal ganglion cell apoptosis in vivo, Annual Meeting of the Association-for-Research-in-Vision-and-Ophthalmology, Publisher: ASSOC RESEARCH VISION OPHTHALMOLOGY INC, Pages: 626-633, ISSN: 0146-0404
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- Citations: 134
Guo L, Tsatourian V, Luong V, et al., 2005, En face optical coherence tomography: a new method to analyse structural changes of the optic nerve head in rat glaucoma, BRITISH JOURNAL OF OPHTHALMOLOGY, Vol: 89, Pages: 1210-1216, ISSN: 0007-1161
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- Citations: 28
Lim KS, Wickremasinghe SS, Cordeiro MF, et al., 2005, Accuracy of intraocular pressure measurements in New Zealand white rabbits, Annual Meeting of the Association-for-Research-in-Vision-and-Ophthalmology, Publisher: ASSOC RESEARCH VISION OPHTHALMOLOGY INC, Pages: 2419-2423, ISSN: 0146-0404
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- Citations: 43
Guo L, Moss SE, Alexander RA, et al., 2005, Retinal ganglion cell apoptosis in glaucoma is related to intraocular pressure and IOP-induced effects on extracellular matrix, INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, Vol: 46, Pages: 175-182, ISSN: 0146-0404
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- Citations: 261
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