Imperial College London
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Professor M Francesca Cordeiro

Faculty of Medicine, Department of Surgery & Cancer

Chair in Ophthalmology (Clinical)
 
 
 
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Contact

 

m.cordeiro

 
 
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Location

 

Norfolk PlaceSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Yap:2019:10.1177/2040622319882205,
author = {Yap, TE and Balendra, SI and Almonte, MT and Cordeiro, MF},
doi = {10.1177/2040622319882205},
journal = {Therapeutic Advances in Chronic Disease},
title = {Retinal correlates of neurological disorders},
url = {http://dx.doi.org/10.1177/2040622319882205},
volume = {10},
year = {2019}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Considering the retina as an extension of the brain provides a platform from which to study diseases of the nervous system. Taking advantage of the clear optical media of the eye and ever-increasing resolution of modern imaging techniques, retinal morphology can now be visualized at a cellular level in vivo. This has provided a multitude of possible biomarkers and investigative surrogates that may be used to identify, monitor and study diseases until now limited to the brain. In many neurodegenerative conditions, early diagnosis is often very challenging due to the lack of tests with high sensitivity and specificity, but, once made, opens the door to patients accessing the correct treatment that can potentially improve functional outcomes. Using retinal biomarkers in vivo as an additional diagnostic tool may help overcome the need for invasive tests and histological specimens, and offers the opportunity to longitudinally monitor individuals over time. This review aims to summarise retinal biomarkers associated with a range of neurological conditions including Alzheimer's disease (AD), Parkinson's disease (PD), multiple sclerosis (MS), amyotrophic lateral sclerosis (ALS) and prion diseases from a clinical perspective. By comparing their similarities and differences according to primary pathological processes, we hope to show how retinal correlates can aid clinical decisions, and accelerate the study of this rapidly developing area of research.
AU  - Yap,TE
AU  - Balendra,SI
AU  - Almonte,MT
AU  - Cordeiro,MF
DO  - 10.1177/2040622319882205
PY  - 2019///
SN  - 2040-6231
TI  - Retinal correlates of neurological disorders
T2  - Therapeutic Advances in Chronic Disease
UR  - http://dx.doi.org/10.1177/2040622319882205
UR  - https://www.ncbi.nlm.nih.gov/pubmed/31832125
UR  - http://hdl.handle.net/10044/1/75683
VL  - 10
ER  -
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