Imperial College London
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Professor M Francesca Cordeiro

Faculty of Medicine, Department of Surgery & Cancer

Chair in Ophthalmology (Clinical)
 
 
 
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Contact

 

m.cordeiro

 
 
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Location

 

Norfolk PlaceSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Moreddu:2020:10.1039/d0lc00438c,
author = {Moreddu, R and Elsherif, M and Adams, H and Moschou, D and Cordeiro, MF and Wolffsohn, JS and Vigolo, D and Butt, H and Cooper, JM and Yetisen, AK},
doi = {10.1039/d0lc00438c},
journal = {Lab on a Chip: miniaturisation for chemistry, physics, biology, materials science and bioengineering},
pages = {3970--3979},
title = {Integration of paper microfluidic sensors into contact lenses for tear fluid analysis},
url = {http://dx.doi.org/10.1039/d0lc00438c},
volume = {20},
year = {2020}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - In this article, using the integration of paper microfluidics within laser-inscribed commercial contact lenses, we demonstrate the multiplexed detection of clinically relevant analytes including hydrogen ions, proteins, glucose, nitrites and L-ascorbic acid, all sampled directly from model tears. In vitro measurements involved the optimization of colorimetric assays, with readouts collected, stored and analyzed using a bespoke Tears Diagnostics smartphone application prototype. We demonstrate the potential of the device to perform discrete measurements either for medical diagnosis or disease screening in the clinic or at the point-of-care (PoC), with future applications including monitoring of ocular infections, uveitis, diabetes, keratopathies and assessing oxidative stress.
AU  - Moreddu,R
AU  - Elsherif,M
AU  - Adams,H
AU  - Moschou,D
AU  - Cordeiro,MF
AU  - Wolffsohn,JS
AU  - Vigolo,D
AU  - Butt,H
AU  - Cooper,JM
AU  - Yetisen,AK
DO  - 10.1039/d0lc00438c
EP  - 3979
PY  - 2020///
SN  - 1473-0189
SP  - 3970
TI  - Integration of paper microfluidic sensors into contact lenses for tear fluid analysis
T2  - Lab on a Chip: miniaturisation for chemistry, physics, biology, materials science and bioengineering
UR  - http://dx.doi.org/10.1039/d0lc00438c
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000584044600007&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - https://pubs.rsc.org/en/content/articlelanding/2020/LC/D0LC00438C
VL  - 20
ER  -
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