Imperial College London
Alternate

ProfessorMartinCowie

Faculty of Medicine, National Heart & Lung Institute

Visiting Professor
 
 
 
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Contact

 

+44 (0)20 7351 8856m.cowie

 
 
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Assistant

 

Mr Jacob Chapman +44 (0)20 7351 8856

 
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Location

 

Chelsea WingRoyal Brompton Campus

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Summary

 

Publications

Citation

BibTex format

@article{Axson:2020:10.1186/s12931-020-1312-7,
author = {Axson, E and Ragutheeswaran, K and Sundaram, V and Bloom, C and Bottle, A and Cowie, M and Quint, J},
doi = {10.1186/s12931-020-1312-7},
journal = {Respiratory Research},
pages = {1--13},
title = {Hospitalisation and mortality in patients with comorbid COPD and heart failure: a systematic review and meta-analysis},
url = {http://dx.doi.org/10.1186/s12931-020-1312-7},
volume = {21},
year = {2020}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - BackgroundDiscrepancy exists amongst studies investigating the effect of comorbid heart failure (HF) on the morbidity and mortality of chronic obstructive pulmonary disease (COPD) patients.MethodsMEDLINE and Embase were searched using a pre-specified search strategy for studies comparing hospitalisation, rehospitalisation, and mortality of COPD patients with and without HF. Studies must have reported crude and/or adjusted rate ratios, risk ratios, odds ratios (OR), or hazard ratios (HR).ResultsTwenty-eight publications, reporting 55 effect estimates, were identified that compared COPD patients with HF with those without HF. One study reported on all-cause hospitalisation (1 rate ratio). Two studies reported on COPD-related hospitalisation (1 rate ratio, 2 OR). One study reported on COPD- or cardiovascular-related hospitalisation (4 HR). One study reported on 90-day all-cause rehospitalisation (1 risk ratio). One study reported on 3-year all-cause rehospitalisation (2 HR). Four studies reported on 30-day COPD-related rehospitalisation (1 risk ratio; 5 OR). Two studies reported on 1-year COPD-related rehospitalisation (1 risk ratio; 1 HR). One study reported on 3-year COPD-related rehospitalisation (2 HR). Eighteen studies reported on all-cause mortality (1 risk ratio; 4 OR; 24 HR). Five studies reported on all-cause inpatient mortality (1 risk ratio; 4 OR). Meta-analyses of hospitalisation and rehospitalisation were not possible due to insufficient data for all individual effect measures. Meta-analysis of studies requiring spirometry for the diagnosis of COPD found that risk of all-cause mortality was 1.61 (pooled HR; 95%CI: 1.38, 1.83) higher in patients with HF than in those without HF.ConclusionsIn this systematic review, we investigated the effect of HF comorbidity on hospitalisation and mortality of COPD patients. There is substantial evidence that HF comorbidity increases COPD-related rehospitalisation and all-cause mortality of COPD patients. The effect of HF
AU  - Axson,E
AU  - Ragutheeswaran,K
AU  - Sundaram,V
AU  - Bloom,C
AU  - Bottle,A
AU  - Cowie,M
AU  - Quint,J
DO  - 10.1186/s12931-020-1312-7
EP  - 13
PY  - 2020///
SN  - 1465-9921
SP  - 1
TI  - Hospitalisation and mortality in patients with comorbid COPD and heart failure: a systematic review and meta-analysis
T2  - Respiratory Research
UR  - http://dx.doi.org/10.1186/s12931-020-1312-7
UR  - http://respiratory-research.biomedcentral.com/articles/10.1186/s12931-020-1312-7
UR  - http://hdl.handle.net/10044/1/77488
VL  - 21
ER  -
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