Imperial College London
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Professor Mark R. Crimmin

Faculty of Natural Sciences, Department of Chemistry

Professor of Organometallic Chemistry
 
 
 
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Contact

 

+44 (0)20 7594 2846m.crimmin Website

 
 
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Location

 

501NMolecular Sciences Research HubWhite City Campus

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Summary

 

Publications

Citation

BibTex format

@article{Crimmin:2018:10.1002/chem.201804580,
author = {Crimmin, MR and Coates, G and Bakewell, C and Ward, B and White, A},
doi = {10.1002/chem.201804580},
journal = {Chemistry - A European Journal},
pages = {16282--16286},
title = {Reactions of fluoroalkanes with Mg-Mg bonds: scope, sp3C-F / sp2C-F coupling and mechanism},
url = {http://dx.doi.org/10.1002/chem.201804580},
volume = {24},
year = {2018}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - sp3C-F bonds of fluoroalkanes (7 examples; 1o, 2o and 3o) undergo addition to a low-valent Mg-Mg species generating reactive organomagnesium reagents. Further reactions with a series of electrophiles results in a net C-F to C-B, C-Si, C-Sn or C-C bond transformation (11 examples, diversity). The new reactivity has been exploited in an unprecedented one-pot magnesium-mediated coupling of sp3C-F and sp2C-F bonds. Calculations suggest that the sp3C-F bond activation step occurs by frontside nucleophilic attack of the Mg-Mg reagent on the fluoroalkane.
AU  - Crimmin,MR
AU  - Coates,G
AU  - Bakewell,C
AU  - Ward,B
AU  - White,A
DO  - 10.1002/chem.201804580
EP  - 16286
PY  - 2018///
SN  - 0947-6539
SP  - 16282
TI  - Reactions of fluoroalkanes with Mg-Mg bonds: scope, sp3C-F / sp2C-F coupling and mechanism
T2  - Chemistry - A European Journal
UR  - http://dx.doi.org/10.1002/chem.201804580
UR  - https://www.ncbi.nlm.nih.gov/pubmed/30207410
UR  - http://hdl.handle.net/10044/1/64442
VL  - 24
ER  -
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