Imperial College London

Dr Michael Crone

Faculty of MedicineDepartment of Infectious Disease

Research Associate
 
 
 
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Contact

 

m.crone Website

 
 
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Location

 

Sir Alexander Fleming BuildingSouth Kensington Campus

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Summary

 

Summary

Michael is currently a Research Associate in the Freemont group working on the development of high throughput diagnostics. He is currently supporting the Imperial College Lighthouse and North West London Pathology (NHS) SARS-CoV-2 testing laboratories as the automation lead. He is also a part of the UK DRI Care Research and Technology Center focusing on developing point of care diagnostics. Apart from these projects he regularly collaborates with and mentors students from the Royal College of Art and organises workshops for the Innovation Design Engineering (IDE) XY Module.

Biography

Dr Michael Crone transitioned into a research-orientated career after initially studying clinical medicine at the University of the Witwatersrand in Johannesburg, South Africa. In 2015 he joined Professor Weinberg's group in the HIV Pathogenesis Research Laboratory at the University of the Witwatersrand where he focused on targeting HIV using CRISPR-Cas9. He continued working on RNA-guided DNA binding proteins, in particular Cas12a, at Imperial College London in Professor Paul Freemont's group, obtaining a Masters degree in Systems and Synthetic Biology funded as a Commonwealth Scholar.

Michael then went on to work for a year as a Research Assistant within the Freemont group, working on scarless genome engineering of bacteria and transcriptional and translational regulation in mammalian cells. In September of 2017, he started a PhD in Synthetic Biology at École polytechnique fédérale de Lausanne where he worked on characterising and engineering gene regulatory networks in S. cerevisiae.

Michael is currently a Research Associate in the Freemont group working on Low Cost Viral Diagnostics as a part of an EPSRC funded project, together with collaborators at the University of Cambridge, CSIR and University of Pretoria (South Africa). He is also a part of the UK DRI Care Research and Technology Center focusing on developing point of care diagnostics. Apart from these projects he regularly collaborates with and mentors students from the Royal College of Art and organises workshops for the Innovation Design Engineering (IDE) XY Module.

RNA guided endonucleases remain his prime interest and in the future he hopes to combine clinical knowledge and synthetic biology to develop novel diagnostics and therapeutics for clinical applications.


Education


MBBCh, University of the Witwatersrand (South Africa)

MRes Systems and Synthetic Biology, Imperial College London

PhD Clinical Medicine Research, Imperial College London (in progress)

Publications

Journals

Crone M, MacDonald J, Freemont P, et al., 2022, gDesigner: computational design of synthetic gRNAs for Cas12a-based transcriptional repression in mammalian cells, Npj Systems Biology and Applications, Vol:8, ISSN:2056-7189, Pages:1-7

Hakki S, Zhou J, Jonnerby J, et al., 2022, Onset and window of SARS-CoV-2 infectiousness and temporal correlation with symptom onset: a prospective, longitudinal, community cohort study., Lancet Respir Med

Gil Rosa B, Akingbade OE, Guo X, et al., 2022, Multiplexed immunosensors for point-of-care diagnostic applications, Biosensors and Bioelectronics, Vol:203, ISSN:0956-5663

Cordery R, Reeves L, Zhou J, et al., 2022, Transmission of SARS-CoV-2 by children to contacts in schools and households: a prospective cohort and environmental sampling study in London, The Lancet Microbe, ISSN:2666-5247

Singanayagam A, Hakki S, Dunning J, et al., 2022, Community transmission and viral load kinetics of the SARS-CoV-2 delta (B.1.617.2) variant in vaccinated and unvaccinated individuals in the UK: a prospective, longitudinal, cohort study., The Lancet. Infectious Diseases, Vol:22, ISSN:1473-3099, Pages:183-195

More Publications