Imperial College London
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Dr Michael Crone

Faculty of Medicine, Department of Infectious Disease

Visiting Researcher
 
 
 
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Contact

 

m.crone Website

 
 
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Location

 

Sir Alexander Fleming BuildingSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Cordery:2021:10.1101/2021.03.08.21252839,
author = {Cordery, R and Reeves, L and Zhou, J and Rowan, A and Watber, P and Rosadas, C and Crone, M and Storch, M and Freemont, P and Mosscrop, L and Cowley, A and Zelent, G and Bisset, K and Blond, HL and Regmi, S and Buckingham, C and Junaideen, R and Abdulla, N and Eliahoo, J and Mindlin, M and Lamagni, T and Barclay, W and Taylor, GP and Sriskandan, S},
doi = {10.1101/2021.03.08.21252839},
title = {Transmission of SARS-CoV-2 by children to contacts in schools and households: a prospective cohort and environmental sampling study in London},
url = {http://dx.doi.org/10.1101/2021.03.08.21252839},
year = {2021}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - <jats:title>Abstract</jats:title><jats:sec><jats:title>Background</jats:title><jats:p>Assessing transmission of SARS-CoV-2 by children in schools is of critical importance to inform public health action. We assessed frequency of acquisition of SARS-CoV-2 by contacts of children with COVID-19 in schools and households, as well as the amount of virus shed into the air and onto fomites in both settings.</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>Cases of COVID-19 in children in London schools were identified via notification. Weekly sampling for 3-4 weeks and PCR testing for SARS-CoV-2 of immediate classroom contacts (the “bubble”), non-bubble school contacts, and household contacts was undertaken supported by genome sequencing, along with surface and air sampling in the school and home environment.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>Within schools, secondary transmission was not detected in 28 individual bubble contacts, representing 10 distinct bubble classes. Across 8 non-bubble classes, 3/62 pupils tested positive– all three were asymptomatic and tested positive in one setting on the same day, unrelated to the original index case. In contrast, the secondary attack rate in naïve household contacts was 14.3% (5/35) rising to 19.1% (9/47) when considering all household contacts. Environmental contamination with SARS-CoV-2 was rare in schools, regardless of school type; fomite SARS-CoV-2 RNA was identified in 4/189 (2.1%) samples in bubble classrooms, 2/127 (1.6%) samples in non-bubble classrooms, and 5/130 (3.8%) samples in washrooms. This contrasted with fomites in households, where SARS-CoV-2 RNA was identified in 60/248 (24.2%) bedroom samples, 66/241 (27.4%) communal room samples, and 21/188 (11.2%) bathroom samples. Air sampling identified SARS-CoV-2 RNA in just 1/68 (1.5%) o
AU  - Cordery,R
AU  - Reeves,L
AU  - Zhou,J
AU  - Rowan,A
AU  - Watber,P
AU  - Rosadas,C
AU  - Crone,M
AU  - Storch,M
AU  - Freemont,P
AU  - Mosscrop,L
AU  - Cowley,A
AU  - Zelent,G
AU  - Bisset,K
AU  - Blond,HL
AU  - Regmi,S
AU  - Buckingham,C
AU  - Junaideen,R
AU  - Abdulla,N
AU  - Eliahoo,J
AU  - Mindlin,M
AU  - Lamagni,T
AU  - Barclay,W
AU  - Taylor,GP
AU  - Sriskandan,S
DO  - 10.1101/2021.03.08.21252839
PY  - 2021///
TI  - Transmission of SARS-CoV-2 by children to contacts in schools and households: a prospective cohort and environmental sampling study in London
UR  - http://dx.doi.org/10.1101/2021.03.08.21252839
ER  -
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