Publications
180 results found
Noseda M, Peterkin T, Simoes FC, et al., 2011, Cardiopoietic Factors Extracellular Signals for Cardiac Lineage Commitment, CIRCULATION RESEARCH, Vol: 108, Pages: 129-152, ISSN: 0009-7330
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- Citations: 93
Obeyesekere N, Ma F, Tesch G, et al., 2010, A POTENTIAL ROLE FOR TGFβ-ACTIVATED KINASE 1 (TAK1) EXPRESSION IN MONONUCLEAR PHAGOCYTES IN LPS-INDUCED ALBUMINURIA, NEPHROLOGY, Vol: 15, Pages: 94-94, ISSN: 1320-5358
Kuroda J, Ago T, Matsushima S, et al., 2010, NADPH oxidase 4 (Nox4) is a major source of oxidative stress in the failing heart, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Vol: 107, Pages: 15565-15570, ISSN: 0027-8424
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- Citations: 568
Greenblatt MB, Shim J-H, Zou W, et al., 2010, The p38 MAPK pathway is essential for skeletogenesis and bone homeostasis in mice, JOURNAL OF CLINICAL INVESTIGATION, Vol: 120, Pages: 2457-2473, ISSN: 0021-9738
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- Citations: 301
Lin S-C, Dolle P, Ryckebuesch L, et al., 2010, Endogenous retinoic acid regulates cardiac progenitor differentiation, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Vol: 107, Pages: 9234-9239, ISSN: 0027-8424
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- Citations: 83
Noseda M, Schneider MD, 2010, Unleashing Cardiopoiesis: A Novel Role for G-CSF, CELL STEM CELL, Vol: 6, Pages: 188-189, ISSN: 1934-5909
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- Citations: 3
Fan Y, Yu Y, Shi Y, et al., 2010, Lysine 63-linked Polyubiquitination of TAK1 at Lysine 158 Is Required for Tumor Necrosis Factor α- and Interleukin-1β-induced IKK/NF-κB and JNK/AP-1 Activation, JOURNAL OF BIOLOGICAL CHEMISTRY, Vol: 285, Pages: 5347-5360
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- Citations: 131
Hidaka K, Shirai M, Lee J-K, et al., 2010, The Cellular Prion Protein Identifies Bipotential Cardiomyogenic Progenitors, CIRCULATION RESEARCH, Vol: 106, Pages: 111-U230, ISSN: 0009-7330
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- Citations: 30
Ma X, Takeda K, Singh A, et al., 2009, Conditional Ablation of Nonmuscle Myosin II-B Delineates Heart Defects in Adult Mice, CIRCULATION RESEARCH, Vol: 105, Pages: 1102-U128, ISSN: 0009-7330
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- Citations: 43
Shirai M, Imanaka-Yoshida K, Schneider MD, et al., 2009, T-box 2, a mediator of Bmp-Smad signaling, induced hyaluronan synthase 2 and Tgfβ2 expression and endocardial cushion formation, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Vol: 106, Pages: 18604-18609, ISSN: 0027-8424
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- Citations: 64
Shim J-H, Greenblatt MB, Xie M, et al., 2009, TAK1 is an essential regulator of BMP signalling in cartilage, The EMBO Journal, Vol: 28, Pages: 2028-2041, ISSN: 0261-4189
TGFβ activated kinase 1 (TAK1), a member of the MAPKKK family, controls diverse functions ranging from innate and adaptive immune system activation to vascular development and apoptosis. To analyse the in vivo function of TAK1 in cartilage, we generated mice with a conditional deletion of Tak1 driven by the collagen 2 promoter. Tak1col2 mice displayed severe chondrodysplasia with runting, impaired formation of secondary centres of ossification, and joint abnormalities including elbow dislocation and tarsal fusion. This phenotype resembled that of bone morphogenetic protein receptor (BMPR)1 and Gdf5‐deficient mice. BMPR signalling was markedly impaired in TAK1‐deficient chondrocytes as evidenced by reduced expression of known BMP target genes as well as reduced phosphorylation of Smad1/5/8 and p38/Jnk/Erk MAP kinases. TAK1 mediates Smad1 phosphorylation at C‐terminal serine residues. These findings provide the first in vivo evidence in a mammalian system that TAK1 is required for BMP signalling and functions as an upstream activating kinase for Smad1/5/8 in addition to its known role in regulating MAP kinase pathways. Our experiments reveal an essential role for TAK1 in the morphogenesis, growth, and maintenance of cartilage.
Noseda M, Schneider MD, 2009, Fibroblasts inform the heart: Control of cardiomyocyte cycling and size by age-dependent paracrine signals, DEV CELL, Vol: 16, Pages: 161-162, ISSN: 1534-5807
Within the developing and adult heart, the fibroblast is often dismissed as merely a structural element, important just to mechanical integrity or to scarring when excessive in disease. leda et al. in this issue of Developmental Cell now report an essential program of paracrine factor production in cardiac fibroblasts that controls heart muscle cell growth, driving cycling or enlargement depending on the fibroblasts' developmental stage.
Yu Y, Ge N, Xie M, et al., 2008, Phosphorylation of Thr-178 and Thr-184 in the TAK1 T-loop Is Required for Interleukin (IL)-1-mediated Optimal NFκB and AP-1 Activation as Well as IL-6 Gene Expression, JOURNAL OF BIOLOGICAL CHEMISTRY, Vol: 283, Pages: 24497-24505, ISSN: 0021-9258
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- Citations: 85
Chen J-F, Murchison EP, Tang R, et al., 2008, Targeted deletion of Dicer in the heart leads to dilated cardiomyopathy and heart failure, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Vol: 105, Pages: 2111-2116, ISSN: 0027-8424
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- Citations: 460
Stroud DM, Gaussin V, Burch JBE, et al., 2007, Abnormal conduction and morphology in the atrioventricular node of mice with atrioventricular canal targeted deletion of Alk3/Bmpr1a receptor., Circulation, Vol: 116, Pages: 2535-2543
BACKGROUND: The atrioventricular (AV) node is essential for the sequential excitation and optimized contraction of the adult multichambered heart; however, relatively little is known about its formation from the embryonic AV canal. A recent study demonstrated that signaling by Alk3, the type 1a receptor for bone morphogenetic proteins, in the myocardium of the AV canal was required for the development of both the AV valves and annulus fibrosus. To test the hypothesis that bone morphogenetic protein signaling also plays a role in AV node formation, we investigated conduction system function and AV node morphology in adult mice with conditional deletion of Alk3 in the AV canal. METHODS AND RESULTS: High-resolution optical mapping with correlative histological analysis of 28 mutant hearts revealed 4 basic phenotypic classes based on electrical activation patterns and volume-conducted ECGs. The frequency of AV node conduction and morphological abnormalities increased from no detectable anomalies (class I) to severe defects (class IV), which included the presence of bypass tracts, abnormal ventricular activation patterns, fibrosis of the AV node, and twin AV nodes. CONCLUSIONS: The present findings demonstrate that bone morphogenetic protein signaling is required in the myocardium of the AV canal for proper AV junction development, including the AV node.
Stroud DM, Gaussin V, Burch JBE, et al., 2007, Abnormal conduction and morphology in the atrioventricular node of mice with atrioventricular canal-targeted deletion of Alk3/Bmpr1a receptor, CIRCULATION, Vol: 116, Pages: 2535-2543, ISSN: 0009-7322
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- Citations: 46
Ding G, Fu M, Qin Q, et al., 2007, Cardiac peroxisome proliferator-activated receptor γ is essential in protecting cardiomyocytes from oxidative damage, CARDIOVASCULAR RESEARCH, Vol: 76, Pages: 269-279, ISSN: 0008-6363
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- Citations: 133
Haudek SB, Taffet GE, Schneider MD, et al., 2007, TNF provokes cardiomyocyte apoptosis and cardiac remodeling through activation of multiple cell death pathways, JOURNAL OF CLINICAL INVESTIGATION, Vol: 117, Pages: 2692-2701, ISSN: 0021-9738
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- Citations: 183
Qu J, Zhou J, Yi XP, et al., 2007, Cardiac-specific haploinsufficiency of β-catenin attenuates cardiac hypertrophy but enhances fetal gene expression in response to aortic constriction, JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, Vol: 43, Pages: 319-326, ISSN: 0022-2828
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- Citations: 55
Chang GY, Cao F, Krishnan M, et al., 2007, Positron emission tomography imaging of conditional gene activation in the heart, JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, Vol: 43, Pages: 18-26, ISSN: 0022-2828
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- Citations: 14
Matus M, Lewin G, Stuempel F, et al., 2007, Cardiomyocyte-specific inactivation of transcription factor CREB in mice, FASEB JOURNAL, Vol: 21, Pages: 1884-1892, ISSN: 0892-6638
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- Citations: 21
Liu Y, Asakura M, Inoue H, et al., 2007, <i>Sox17</i> is essential for the specification of cardiac mesoderm in embryonic stem cells, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Vol: 104, Pages: 3859-3864, ISSN: 0027-8424
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- Citations: 133
Hilfiker-Kleiner D, Kaminski K, Podewski E, et al., 2007, A cathepsin D-cleaved 16 kDa form of prolactin mediates postpartum cardiomyopathy, CELL, Vol: 128, Pages: 589-600, ISSN: 0092-8674
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- Citations: 599
Sano M, Izumi Y, Helenius K, et al., 2007, Menage-a-trois 1 is critical for the transcriptional function of PPARγ coactivator 1, CELL METABOLISM, Vol: 5, Pages: 129-142, ISSN: 1550-4131
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- Citations: 51
Eckardt D, Kirchhoff S, Kim J-S, et al., 2006, Cardiomyocyte-restricted deletion of Connexin43 during mouse development, JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, Vol: 41, Pages: 963-971, ISSN: 0022-2828
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- Citations: 35
Xie M, Zhang D, Dyck JRB, et al., 2006, A pivotal role for endogenous TGF-β-activated kinase-1 in the LKB1/AMP-activated protein kinase energy-sensor pathway, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Vol: 103, Pages: 17378-17383, ISSN: 0027-8424
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- Citations: 282
Chang J, Xie M, Shah VR, et al., 2006, Activation of Rho-associated coiled-coil protein kinase 1 (ROCK-1) by caspase-3 cleavage plays an essential role in cardiac myocyte apoptosis, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Vol: 103, Pages: 14495-14500, ISSN: 0027-8424
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- Citations: 196
Mysliwiec MR, Chen J, Powers PA, et al., 2006, Generation of a conditional null allele of jumonji, GENESIS, Vol: 44, Pages: 407-411, ISSN: 1526-954X
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- Citations: 11
Liu H-H, Xie M, Schneider MD, et al., 2006, Essential role of TAK1 in thymocyte development and activation, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Vol: 103, Pages: 11677-11682, ISSN: 0027-8424
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- Citations: 132
Wan YY, Chi H, Xie M, et al., 2006, The kinase TAK1 integrates antigen and cytokine receptor signaling for T cell development, survival and function, NATURE IMMUNOLOGY, Vol: 7, Pages: 851-858, ISSN: 1529-2908
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- Citations: 215
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