Publications

BibTex format

@article{Buyandelger:2015:10.1161/CIRCGENETICS.113.000690,
author = {Buyandelger, B and Mansfield, C and Kostin, S and Choi, O and Roberts, AM and Ware, JS and Mazzarotto, F and Pesce, F and Buchan, R and Isaacson, RL and Vouffo, J and Gunkel, S and Knöll, G and McSweeney, SJ and Wei, H and Perrot, A and Pfeiffer, C and Toliat, MR and Ilieva, K and Krysztofinska, E and López-Olañeta, MM and Gómez-Salinero, JM and Schmidt, A and Ng, KE and Teucher, N and Chen, J and Teichmann, M and Eilers, M and Haverkamp, W and Regitz-Zagrosek, V and Hasenfuss, G and Braun, T and Pennell, DJ and Gould, I and Barton, PJ and Lara-Pezzi, E and Schafer, S and Hübner, N and Felkin, LE and O'Regan, DP and Petretto, E and Brand, T and Milting, H and Nürnberg, P and Schneider, MD and Prasad, S and Knöll, R},
doi = {10.1161/CIRCGENETICS.113.000690},
journal = {Circulation. Cardiovascular Genetics},
pages = {643--652},
title = {ZBTB17 (MIZ1) Is Important for the Cardiac Stress Response and a Novel Candidate Gene for Cardiomyopathy and Heart Failure.},
url = {http://dx.doi.org/10.1161/CIRCGENETICS.113.000690},
volume = {8},
year = {2015}
}

Download

RIS format (EndNote, RefMan)

TY  - JOUR
AB  - BACKGROUND: -Mutations in sarcomeric and cytoskeletal proteins are a major cause of hereditary cardiomyopathies, but our knowledge remains incomplete as to how the genetic defects execute their effects. METHODS AND RESULTS: -We used cysteine and glycine-rich protein 3 (CSRP3), a known cardiomyopathy gene, in a yeast two-hybrid screen and identified zinc finger and BTB domain containing protein 17 (ZBTB17) as a novel interacting partner. ZBTB17 is a transcription factor that contains the peak association signal (rs10927875) at the replicated 1p36 cardiomyopathy locus. ZBTB17 expression protected cardiac myocytes from apoptosis in vitro and in a mouse model with cardiac myocyte-specific deletion of Zbtb17, which develops cardiomyopathy and fibrosis after biomechanical stress. ZBTB17 also regulated cardiac myocyte hypertrophy in vitro and in vivo in a calcineurin-dependent manner. CONCLUSIONS: -We revealed new functions for ZBTB17 in the heart, a transcription factor which may play a role as a novel cardiomyopathy gene.
AU  - Buyandelger,B
AU  - Mansfield,C
AU  - Kostin,S
AU  - Choi,O
AU  - Roberts,AM
AU  - Ware,JS
AU  - Mazzarotto,F
AU  - Pesce,F
AU  - Buchan,R
AU  - Isaacson,RL
AU  - Vouffo,J
AU  - Gunkel,S
AU  - Knöll,G
AU  - McSweeney,SJ
AU  - Wei,H
AU  - Perrot,A
AU  - Pfeiffer,C
AU  - Toliat,MR
AU  - Ilieva,K
AU  - Krysztofinska,E
AU  - López-Olañeta,MM
AU  - Gómez-Salinero,JM
AU  - Schmidt,A
AU  - Ng,KE
AU  - Teucher,N
AU  - Chen,J
AU  - Teichmann,M
AU  - Eilers,M
AU  - Haverkamp,W
AU  - Regitz-Zagrosek,V
AU  - Hasenfuss,G
AU  - Braun,T
AU  - Pennell,DJ
AU  - Gould,I
AU  - Barton,PJ
AU  - Lara-Pezzi,E
AU  - Schafer,S
AU  - Hübner,N
AU  - Felkin,LE
AU  - O'Regan,DP
AU  - Petretto,E
AU  - Brand,T
AU  - Milting,H
AU  - Nürnberg,P
AU  - Schneider,MD
AU  - Prasad,S
AU  - Knöll,R
DO  - 10.1161/CIRCGENETICS.113.000690
EP  - 652
PY  - 2015///
SN  - 1942-3268
SP  - 643
TI  - ZBTB17 (MIZ1) Is Important for the Cardiac Stress Response and a Novel Candidate Gene for Cardiomyopathy and Heart Failure.
T2  - Circulation. Cardiovascular Genetics
UR  - http://dx.doi.org/10.1161/CIRCGENETICS.113.000690
UR  - http://hdl.handle.net/10044/1/25683
VL  - 8
ER  -

Download

Emeritus ProfessorMichaelSchneider

Contact

Location

Summary

Citation

BibTex format

RIS format (EndNote, RefMan)