Imperial College London
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ProfessorMarcDionne

Faculty of Natural Sciences, Department of Life Sciences

Professor of Innate Immunity
 
 
 
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Contact

 

+44 (0)20 7594 5776m.dionne Website

 
 
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Location

 

G.23Flowers buildingSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Vincent:2021:10.1101/2021.08.24.457493,
author = {Vincent, CM and Beckwith, EJ and Pearson, WH and Kierdorf, K and Gilestro, G and Dionne, MS},
doi = {10.1101/2021.08.24.457493},
title = {Infection increases activity via <i>Toll</i> dependent and independent mechanisms in <i>Drosophila melanogaster</i>},
url = {http://dx.doi.org/10.1101/2021.08.24.457493},
year = {2021}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - <jats:title>Abstract</jats:title><jats:p>Host behavioural changes are among the most apparent effects of infection. ‘Sickness behaviour’ can involve a variety of symptoms, including anorexia, depression, and changed activity levels. Here we use a real-time tracking and behavioural profiling platform to show that, in <jats:italic>Drosophila melanogaster</jats:italic>, many systemic bacterial infections cause significant increases in physical activity, and that the extent of this activity increase is a predictor of survival time in several lethal infections. Using various bacteria and <jats:italic>D. melanogaster</jats:italic> immune and activity mutants, we show that increased activity is driven by at least two different mechanisms. Increased activity after infection with <jats:italic>Micrococcus luteus</jats:italic>, a Gram-positive bacterium rapidly cleared by the immune response, strictly requires the <jats:italic>Toll</jats:italic> ligand <jats:italic>spätzle</jats:italic> and Toll-pathway activity in the fat body and the brain. In contrast, increased activity after infection with <jats:italic>Francisella novicida</jats:italic>, a Gram-negative bacterium that cannot be cleared by the immune response, is entirely independent of either <jats:italic>spätzle</jats:italic> or the parallel IMD pathway. The existence of multiple signalling mechanisms by which bacterial infections drive increases in physical activity implies that this effect may be an important aspect of the host response.</jats:p>
AU  - Vincent,CM
AU  - Beckwith,EJ
AU  - Pearson,WH
AU  - Kierdorf,K
AU  - Gilestro,G
AU  - Dionne,MS
DO  - 10.1101/2021.08.24.457493
PY  - 2021///
TI  - Infection increases activity via <i>Toll</i> dependent and independent mechanisms in <i>Drosophila melanogaster</i>
UR  - http://dx.doi.org/10.1101/2021.08.24.457493
ER  -
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