Imperial College London
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ProfessorMarcDionne

Faculty of Natural Sciences, Department of Life Sciences

Professor of Innate Immunity
 
 
 
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Contact

 

+44 (0)20 7594 5776m.dionne Website

 
 
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Location

 

G.23Flowers buildingSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Srinivasan:2016:10.7554/eLife.19662,
author = {Srinivasan, N and Gordon, O and Ahrens, S and Franz, A and Deddouche, S and Chakravarty, P and Phillips, D and Yunus, AA and Rosen, MK and Valente, RS and Teixeira, L and Thompson, B and Dionne, MS and Wood, W and Reis, e Sousa C},
doi = {10.7554/eLife.19662},
journal = {eLife},
title = {Actin is an evolutionarily-conserved damage-associated molecular pattern that signals tissue injury in Drosophila melanogaster},
url = {http://dx.doi.org/10.7554/eLife.19662},
volume = {5},
year = {2016}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Damage-associated molecular patterns (DAMPs) are molecules released by dead cells that trigger sterile inflammation and, in vertebrates, adaptive immunity. Actin is a DAMP detected in mammals by the receptor, DNGR-1, expressed by dendritic cells (DCs). DNGR-1 is phosphorylated by Src-family kinases and recruits the tyrosine kinase Syk to promote DC cross-presentation of dead cell-associated antigens. Here we report that actin is also a DAMP in invertebrates that lack DCs and adaptive immunity. Administration of actin to Drosophila melanogaster triggers a response characterised by selective induction of STAT target genes in the fat body through the cytokine Upd3 and its JAK/STAT-coupled receptor, Domeless. Notably, this response requires signalling via Shark, the Drosophila orthologue of Syk, and Src42A, a Drosophila Src-family kinase, and is dependent on Nox activity. Thus, extracellular actin detection via a Src-family kinase-dependent cascade is an ancient means of detecting cell injury that precedes the evolution of adaptive immunity.
AU  - Srinivasan,N
AU  - Gordon,O
AU  - Ahrens,S
AU  - Franz,A
AU  - Deddouche,S
AU  - Chakravarty,P
AU  - Phillips,D
AU  - Yunus,AA
AU  - Rosen,MK
AU  - Valente,RS
AU  - Teixeira,L
AU  - Thompson,B
AU  - Dionne,MS
AU  - Wood,W
AU  - Reis,e Sousa C
DO  - 10.7554/eLife.19662
PY  - 2016///
SN  - 2050-084X
TI  - Actin is an evolutionarily-conserved damage-associated molecular pattern that signals tissue injury in Drosophila melanogaster
T2  - eLife
UR  - http://dx.doi.org/10.7554/eLife.19662
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000390319900001&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - http://hdl.handle.net/10044/1/44003
VL  - 5
ER  -
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